- Game Preview: Arizona Cardinals vs Indianapolis Colts
- Date: Sunday, October 12, 2025
- Venue: Lucas Oil Stadium, Indianapolis, IN
- Broadcast: FOX
- Point Spread: Colts favored by 6.5 points
- Over/Under Total: 47.5 points
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The Arizona Cardinals (2-3) travel to Lucas Oil Stadium this Sunday to face off against the Indianapolis Colts (4-1). The Colts are entering this matchup as 6.5-point favorites, with the total set at 47.5.
Currently with a record of 2-3, the Arizona Cardinals are looking to turn their fortune around. In their last outing, they suffered a narrow defeat against the Tennessee Titans, losing 22-21. Michael Carter led the ground game, carrying the ball 18 times for 51 yards (an average of 2.8 yards per carry). He also made 5 receptions for 22 yards, averaging 4.4 yards per catch. Quarterback Kyler Murray went 23-for-31, accumulating 220 passing yards with a QB rating of 93.5, and notably did not throw any interceptions. Defensively, the Cardinals allowed 78 rushing yards on 24 attempts, which equates to an average of 3.3 yards per carry. They conceded 21 completions on 39 passes for a total of 249 yards, with a completion rate of 53.8%. In total, Arizona executed 61 plays for 360 yards, running the ball 29 times for an impressive average of 5.8 yards per carry.
On the season, the Cardinals have amassed a total of 1,442 yards. With 50 first downs, they have also faced 41 penalties resulting in 273 yards. In terms of scoring, Arizona has achieved 6 touchdown passes and 4 rushing touchdowns, while they have turned the ball over 6 times (3 interceptions and 3 fumbles). Offensively, they are averaging 118.2 rushing yards per game, placing them 12th in the league. In total, Arizona scores an average of 20.6 points per game in the NFC West.
Defensively, the Cardinals have allowed 1,271 passing yards, ranking them 29th in the league, giving up an average of 254.2 passing yards per game along with a completion percentage of 61.8%. They have also allowed 462 rushing yards throughout the season; in total, they have given up 5 touchdowns through the air and 3 on the ground. Overall, Arizona is allowing 346.6 total yards per game, putting them at 21st in the NFL. Opponents are averaging 3.9 yards per rush and 92.4 rushing yards per game against the Cardinals. Notably, Arizona ranks 4th in opponent scoring, giving up an average of just 19.2 points per contest.
The Colts enter this contest boasting a record of 4-1. In their most recent game, they secured a dominant 40-6 victory over the Las Vegas Raiders. Daniel Jones threw for 212 yards, completing 20 of 29 passes with 2 TDs and a quarterback rating of 113, no interceptions, and averaging 7.3 yards per attempt. Josh Downs was a highlight, catching 6 passes for 54 yards (9.0 yards per catch). Jonathan Taylor contributed to the offense with 17 carries for 66 yards, averaging 3.9 yards per carry. Overall, the Colts aggregated 317 yards from 57 plays, averaging 5.6 yards per play. On defense, Indianapolis allowed 25 rushing attempts for 106 yards (4.2 yards per attempt) and their pass defense conceded a 69.4% completion rate for 190 yards on 25 of 36 passing.
In scoring, the Colts are currently sitting at an impressive second in the league with an average of 32.6 points per game. Through the air, they have accumulated 1,265 yards this season, averaging 253 yards per game—ranking 4th in the NFL. The Colts’ rushing attack boasts an impressive average of 128.2 yards per game, totaling 641 rushing yards so far. Overall, the Indianapolis offense generates an average of 381.2 total yards per contest, placing them 4th in the league. However, they have contributed to their opponents with 301 yards due to 39 penalties, placing them 12th in terms of helping the opposition. They have registered 2 interceptions while allowing 1 fumble, along with achieving 63 first downs.
The Colts’ defense has allowed only 17.8 points per game, ranking them 3rd in the league. They have given up 8 passing touchdowns along with an average of 217 passing yards per game, which ranks 19th in the NFL. In terms of rushing, they have allowed 490 yards (98 yards per game) and 2 rushing touchdowns this season. They have made 300 total defensive plays, ranking 17th in the league, while forcing 8 turnovers (2 fumble recoveries and 6 interceptions) overall, yielding a total of 89 points.
Who do you think will win the Cardinals vs. Colts matchup against the spread?
Pick: Cardinals +6.5
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