Arizona Cardinals vs New Orleans Saints Week 1 Prediction, NFL Picks, Best Bets & Odds for 9/7/2025

Home » Arizona Cardinals vs New Orleans Saints Week 1 Prediction, NFL Picks, Best Bets & Odds for 9/7/2025

Matchup: Arizona Cardinals vs New Orleans Saints

Date: Sunday, September 7, 2025

Venue: Caesars Superdome, New Orleans, LA

Broadcast: CBS

Betting Odds: Saints (+6.5)

Over/Under Total: 43

The Caesars Superdome will host an exciting game where the New Orleans Saints (5-12 last season) aim to overcome the Arizona Cardinals (8-9 last season) this Sunday. Arizona enters the matchup as 6.5-point favorites, with the over-under set at 43 points.

Last season, the Arizona Cardinals wrapped up with an 8-9 record. In their final outing, they triumphed over the San Francisco 49ers with a commanding 47-24 victory. Quarterback Kyler Murray completed 25 of 35 passes for 242 yards and threw 4 touchdowns, achieving a quarterback rating of 128.5 and a clean slate with no interceptions. Trey McBride averaged 9.3 yards per catch, accumulating 65 yards on 7 receptions. The rushing efforts were led by Tony Jones, who notched 55 yards on 4 carries (averaging 13.8 yards per attempt). The team ran a total of 62 plays, accumulating 393 yards, while they executed 27 rushes for 151 yards, resulting in an average of 5.6 yards per carry. In terms of defense, the Cardinals allowed 138 rushing yards on 28 carries (averaging 4.9 yards), and conceded 29 completions on 43 attempts for a total of 298 passing yards, a completion percentage of 67.4%.

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Analyzing the touchdowns, the representatives of the NFC West averaged 23.5 points per game, recording 144.2 rushing yards (ranking 7th in the NFL). The Cardinals amassed 6,090 total yards throughout the season, converting 191 first downs as a team, along with 92 penalties resulting in 806 yards. They had 20 turnovers (11 interceptions and 9 fumbles lost), scoring 21 touchdowns through the air and 18 on the ground.

In defensive metrics, the Cardinals ranked 15th overall, allowing an average of 22.3 points per game. They conceded 4.6 yards per carry and 126.4 rushing yards per game, totaling 2,149 yards on the ground over 17 games last season. In passing defense, they yielded 3,674 yards, putting them 14th in the league. They allowed an average of 216.1 passing yards per game with a completion percentage of 68.6%. Overall, they surrendered 342.5 yards per game, placing 21st in professional football, along with 20 passing touchdowns and 18 rushing touchdowns.

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The Saints completed their season with a 5-12 record. In their last game, they faced the Tampa Bay Buccaneers and were defeated 27-19. Spencer Rattler delivered a performance with 1 touchdown, tallying 240 yards on 26 of 42 passing attempts and finishing with a quarterback rating of 85.4, avoiding interceptions with an average of 5.7 yards per attempt. Juwan Johnson was the standout receiver, catching 6 passes for 80 yards (averaging 13.3 yards per catch). Clyde Edwards-Helaire carried the ball 8 times for 26 yards, averaging 3.3 yards per carry. The Saints’ offense recorded a total of 292 yards while executing 61 plays (averaging 4.8 yards per play), rushing for an average of 3.4 yards per carry with a total of 64 yards on 19 attempts. Conversely, their defense conceded 31 rushing attempts for 179 yards (5.8 yards per rush) and allowed a completion rate of 65.6%, giving up 216 yards on 21 of 32 passing attempts.

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The New Orleans Saints averaged 320.1 total yards per game, ranking 21st in the league. They recorded an average of 114.9 rushing yards per game, accumulating a total of 1,954 rushing yards. The Saints offense gave away 1,003 total yards via 110 penalties, placing them 17th in the league for mistakes. Last season, the Saints amassed 3,488 passing yards, averaging 205.2 yards per game, ranking 23rd in the NFL. In terms of scoring efficiency, they settled at 24th in the league with an average of 19.9 points per game.

On the defensive side, they permitted 19 passing touchdowns and 238.5 passing yards per game, ranking them 27th in the NFL. They allowed 2,404 rushing yards (averaging 141.4 yards per game) and 20 rushing touchdowns last season. Their defense managed 17 takeaways (3 forced fumbles and 14 interceptions). The Saints participated in 1,119 plays from scrimmage, ranking them 30th in professional football, while yielding an average of 23.4 points per game, placing 19th overall.

Which team will secure victory in the Cardinals-Saints matchup against the spread?

Tony’s Recommendation: Bet on the Cardinals -6.5

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