Arizona Diamondbacks vs San Diego Padres Prediction for 7/10/2025 MLB Picks, Top Bets & Odds

Home » Arizona Diamondbacks vs San Diego Padres Prediction for 7/10/2025 MLB Picks, Top Bets & Odds

Matchup: Arizona Diamondbacks vs. San Diego Padres

Date: Thursday, July 10, 2025

Venue: Petco Park, San Diego, CA

Broadcast: Padres.TV

Betting Odds: Arizona (+125), San Diego (-145)

The San Diego Padres (48-42) are set to face off against the Arizona Diamondbacks (45-46) at Petco Park this Thursday. The betting odds show Arizona at +125 while San Diego stands at -145. The total points line is set at 8.5. The anticipated starting pitchers for this matchup are Eduardo Rodriguez and Randy Vasquez.

MLB Predictions: Jackson Merrill's San Diego Padres Insights

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The Diamondbacks have notched 158 doubles and 133 home runs as a team this season. With a slugging percentage of .446, they have struck out 716 times while also earning 323 walks. As a collective unit, the Arizona Diamondbacks are scoring 5.1 runs per game, placing them 3rd in the league. They have secured 457 RBIs and recorded 778 hits thus far, boasting a batting average of .252. With a total of 467 runs scored, their on-base percentage stands at .328.

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The Diamondbacks’ strikeout-to-walk ratio is 2.68, and their pitching staff has recorded a WHIP of 1.33. Thus far, they have allowed 119 home runs and a total of 464 runs (ranked 27th in MLB). Arizona’s pitchers have surrendered 787 hits (8.7 per 9 innings) and 422 earned runs. Their current team ERA stands at 4.68 (26th in the league), with a total of 786 strikeouts recorded. The staff has issued 293 walks, with a FIP of 4.29.

This season, the Diamondbacks have utilized 284 relief pitchers. Their relievers have inherited 99 base runners, with 34.3% scoring a run. So far, they’ve achieved 27 saves out of 44 opportunities, resulting in a save percentage of 61.4%. The bullpen has recorded 52 holds (14th in MLB). The Diamondbacks’ pitchers have entered games with players on base 77 times and have made 87 high-leverage appearances.

Defensively, Arizona has made 2,437 putouts, with 799 assists and 47 errors, earning a fielding percentage of .986 (19th in MLB) and completing 71 double plays. They convert 69.0% of balls in play into outs, ranking them 21st in the league over 7,311 innings.

Eduardo Rodriguez boasts 1,226 innings pitched with 1,241 career strikeouts. His earned run average is 4.18, having allowed 570 earned runs throughout his MLB career, while maintaining a WHIP of 1.322. He has given up 1,199 hits (8.8 per nine innings) and recorded 422 walks, with a career record of 88-62 and facing 5,239 batters.

The San Diego Padres have tallied 76 home runs and 341 RBIs this season, along with 129 doubles and 295 walks. Their on-base percentage is .316, with a team batting average of .246. The Padres have a slugging percentage of .373, averaging 4.07 runs per game (23rd in MLB). They have struck out 639 times (28th in the league) and compiled 737 hits.

As a pitching staff, the Padres hold a WHIP of 1.237 and a FIP of 3.85. Their strikeout-to-walk ratio stands at 8.70 (773 strikeouts against 298 walks). They rank 4th in the league for least hits allowed, giving up 687 total hits. So far, they have yielded 89 home runs and allow 4.04 runs per nine innings (10th in the league), with an overall ERA of 3.69.

With 102 save situations, the Padres have recorded 60 holds and 11 blown saves. Padres’ relievers have been called upon in 41 save attempts, securing 30 saves. They’ve entered 123 high-leverage situations and appeared 104 times with runners on base. The inherited scoring rate for their relievers is 34.7%, ranking 3rd in MLB with a save rate of 73.2%. This season, they’ve deployed 317 bullpen pitchers.

Over 7,164 innings played, the Padres demonstrate a defensive efficiency of 70.9% (9th in MLB). The team has executed 62 double plays and has a fielding percentage of .986 (14th in professional baseball). So far this season, San Diego has achieved 690 assists, 43 errors, and 2,388 putouts.

Randy Vasquez has a 9-13 win-loss record with a 4.11 ERA, allowing 9.2 hits per nine innings. His strikeout-to-walk ratio is 1.62, and he has faced 988 opposing hitters throughout his career. He has given up 103 earned runs, with a WHIP of 1.416 and a FIP of 4.1. Over his career, Vasquez has allowed 230 hits and has recorded 144 strikeouts in 225 innings pitched.

Who will emerge victorious in tonight’s MLB contest against the spread or moneyline?

Guy Bruhn’s Prediction: Back Arizona (+125)

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