Arizona Wildcats vs Iowa State Cyclones Forecast, 9/27/2025 College Football Selections, Top Bets & Odds

Home » Arizona Wildcats vs Iowa State Cyclones Forecast, 9/27/2025 College Football Selections, Top Bets & Odds
  • Matchup: Arizona Wildcats vs Iowa State Cyclones
  • Date: Saturday, September 27, 2025
  • Venue: Jack Trice Stadium, Ames, IA
  • Broadcast: ESPN
  • Point Spread: Cyclones favored by 6.5 points
  • Total Points Line: 50

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On Saturday, September 27, 2025, Jack Trice Stadium will host the thrilling matchup between the Iowa State Cyclones (4-0) and the Arizona Wildcats (3-0). The Cyclones are currently favored by 6.5 points, and the total points are set at 50.

The Arizona Wildcats enter this contest with an impressive 3-0 record for the season. In their most recent game, they emerged victorious against the Kansas State Wildcats, finishing with a score of 23-17. During this match, the Wildcats allowed 105 rushing yards on 24 carries, averaging 4.4 yards per rush. In terms of pass defense, Arizona gave up 13 completions out of 29 attempts for 88 yards, resulting in a completion percentage of 44.8%. By the end of the game, the Wildcats executed 79 offensive plays, accumulating a total of 412 yards. Additionally, they rushed 45 times for 234 yards, averaging 5.2 yards per carry.

College Football Picks: Chase Sowell Iowa State Cyclones Predictions and Best Bet Odds

This season, the Wildcats have amassed a total of 1,312 offensive yards. In terms of scoring, Arizona has achieved 6 touchdowns through the air and another 6 on the ground, with just 2 turnovers recorded. The Wildcats have registered 68 first downs and faced 25 penalties, resulting in 190 yards lost. Their ground game averages 189.0 yards per game, positioning them 49th in Division 1. Overall, Arizona boasts an average of 37.0 points scored per game.

Defensively, the Wildcats have given up 379 passing yards, placing them 9th in Division 1. They have allowed an average of 126.3 passing yards per game with a completion percentage of 48.9%. In total, the Wildcats have allowed 222.3 yards per game this season, ranking 7th in the nation for yardage conceded. Opponents have scored no touchdowns through the air and only 2 on the ground. The rushing offense against the Wildcats averages 3.4 yards per attempt and 96.0 rushing yards per game. Over the past 3 games, Arizona has given up 288 rushing yards and ranks 7th in Division 1 for opponent scoring, allowing just 8.7 points per game.

The Cyclones flaunt a perfect 4-0 record this season. In their latest match, they secured a win against the Arkansas State Red Wolves with a final score of 24-16. Iowa State tallied 452 yards on 59 plays, averaging 7.7 yards per play. Their ground game was strong, averaging 5.5 yards per carry, totaling 187 yards on 34 attempts. The Cyclones’ defense allowed 40 carries for 160 yards, averaging 4.0 yards per rush, while their secondary conceded 222 yards on 19 completions out of 33 attempts, resulting in a completion rate of 57.6%.

The Iowa State Cyclones are averaging 383.0 yards per game, ranking 79th nationally. Their offense has incurred 108 yards in penalties across 12 infractions, placing them at 128th in the nation in this regard. On the ground, they average 161.0 rushing yards per game, with a total of 644 rushing yards so far. They have thrown 1 interception and lost 3 fumbles, generating 81 first downs. In terms of scoring, the Cyclones rank 74th in the country with an average of 29.8 points per game. Additionally, they have accumulated 888 passing yards this season, averaging 222.0 passing yards per game, which also ranks 74th in the nation.

On the defensive side, the Cyclones allow 14.3 points per game, placing them 22nd in Division 1. They have yielded 484 rushing yards this season (121.0 yards per game) along with 3 rushing touchdowns. In terms of passing, they have allowed 3 touchdowns and an average of 176.0 yards per game, ranking 35th in the nation. The Cyclones’ defense has participated in 244 plays overall, ranking 65th in college football. They have made 2 fumble recoveries and 4 interceptions this season, giving up a total of 57 points.

Who will come out on top in this exhilarating Wildcats versus Cyclones showdown?

Prediction: Support the Cyclones -6.5

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Pick: Iowa State Cyclones -6.5
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