- Matchup: Atlanta Falcons vs San Francisco 49ers
- Date: Sunday, October 19, 2025
- Venue: Levi’s Stadium, Santa Clara, CA
- Broadcast: NBC
- Betting Odds: 49ers favored by 2 points
- Total Points Over/Under: 47.5
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This Sunday, the San Francisco 49ers (4-2) aim to secure a victory over the Atlanta Falcons (3-2) at Levi’s Stadium. The Falcons enter the game as 2-point underdogs, with a total points line set at 47.5.
The Atlanta Falcons bring a 3-2 record into this matchup. In their most recent outing, they took on the Buffalo Bills, clinching a win with a score of 24-14. Quarterback Michael Penix threw for 250 yards on 20 of 32 attempts, scoring 1 touchdown and achieving a passer rating of 97.1 without an interception. Running back Bijan Robinson was instrumental, accumulating 170 rushing yards on 19 carries (averaging 8.9 yards per carry). Receiver Drake London showcased his skills, making 10 receptions for 158 yards at an impressive average of 15.8 yards per catch. The Falcons performed well on the ground, earning 210 rushing yards on 32 attempts (6.6 yards per carry) and totaling 443 yards over 64 offensive plays. Defensively, Atlanta allowed 15 completions on 26 attempts for 157 yards, with a completion percentage of 57.7%. The Falcons’ defensive line faced challenges, giving up 134 rushing yards on 24 attempts, averaging 5.6 yards per carry surrendered.

In terms of offensive performance, the Falcons average 20.0 points per game. They rank first in the league with an average of 151.2 rushing yards per game. So far this season, Atlanta has compiled 1,894 total offensive yards, 56 first downs, and incurred 27 penalties for a loss of 187 yards. They have committed 5 turnovers (3 interceptions and 2 fumbles). When it comes to scoring, Atlanta has secured 4 touchdowns through the air and 6 on the ground.
Defensively, the Falcons have allowed 697 passing yards this season, placing them atop the league in that category. They give up an average of 139.4 passing yards per game with a completion rate of 57.7%. Overall, they have allowed 570 rushing yards across 5 games, conceding 7 passing touchdowns and 2 rushing touchdowns. Their total yardage allowed per game stands at 253.4 yards, which ranks them first in the NFL. They’re allowing 4.8 yards per rushing attempt and 114.0 rushing yards per game this season, making them the 7th best in team defense with an average of 20.0 points allowed per game.
The San Francisco 49ers head into this game with a 4-2 record for the season. In their previous match, they faced off against the Tampa Bay Buccaneers, suffering a defeat with a score of 30-19. Quarterback Mac Jones recorded 347 passing yards on 27 of 39 attempts, with a quarterback rating of 75.5, but he did throw 2 interceptions with an average of 8.9 yards per pass. In the passing attack, Christian McCaffrey was a standout, securing 7 receptions for 57 yards (averaging 8.1 yards per reception). On the ground, McCaffrey tallied 54 yards on 17 carries, finishing with 3.2 yards per rush. The 49ers totaled 363 offensive yards from 61 plays (averaging 6.0 yards per play). They averaged 3.0 yards per carry with 22 attempts to finish with 67 rushing yards. The San Francisco defense allowed 104 rushing yards on 26 attempts (4.0 yards per carry). Their passing defense surrendered a completion percentage of 73.9%, allowing 248 yards on 17 of 23 pass attempts.
Defensively, the 49ers are allowing an average of 21.3 points per game, placing them 15th in the league. They have given up 10 touchdowns through the air and allow 214.3 passing yards per game, ranking them 18th in the NFL. The 49ers have conceded a total of 644 rushing yards (107.3 yards per game) and 4 rushing touchdowns this year. They’ve participated in 358 plays from scrimmage, ranking 16th in football and have recorded 5 turnovers this season, giving up a total of 128 points.
Who will emerge victorious in this Falcons vs. 49ers NFL showdown against the spread?
Prediction: Bet on the Falcons +2
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