Buffalo Bills vs Houston Texans Predictions for 11/20/2025 NFL Picks, Best Bets & Odds for Week 12

Home » Buffalo Bills vs Houston Texans Predictions for 11/20/2025 NFL Picks, Best Bets & Odds for Week 12

  • Matchup: Buffalo Bills vs Houston Texans
  • Event Date: Thursday, November 20, 2025
  • Venue: NRG Stadium, Houston, TX
  • Broadcast: Prime Video
  • Betting Odds: Texans (+5.5)
  • Total Points Over/Under: 43.5

This page may include affiliate links at no extra cost to you, thanks for your support.

This Thursday, the Houston Texans (5-5) will host the Buffalo Bills (7-3) at NRG Stadium. The Bills are favored by 5.5 points according to the latest Vegas odds, and the total score line is set at 43.5.

The Buffalo Bills approach this game with a solid record of 7-3. In their recent matchup, they triumphed over the Tampa Bay Buccaneers with a score of 44-32. Quarterback Josh Allen completed 19 of 30 passes for 317 yards and 3 touchdowns, achieving a quarterback rating of 104.4 despite throwing 2 interceptions. Tyrell Shavers was a standout receiver, averaging 22.5 yards per reception with 90 yards on 4 catches. James Cook led the rushing effort with 16 carries for 48 yards, averaging 3.0 yards per attempt. Overall, the Bills executed 53 plays totaling 414 yards, rushing 23 times for 97 yards at an average of 4.2 yards per carry. Defensively, they allowed 202 rushing yards on 39 attempts, averaging 5.2 yards per run, and permitted 16 completions on 28 attempts for 165 yards, yielding a 57.1% completion rate.

NFL Predictions James Cook Buffalo Bills Best Bet Odds

This season, the Bills have amassed 3,874 yards, with 121 first downs recorded. However, they have faced 68 penalties, costing them 563 yards. Buffalo has scored 18 touchdowns through the air and 19 on the ground while turning the ball over 12 times (7 interceptions and 5 fumbles). Impressively, they average 147.6 rushing yards, ranking them 1st in the league, and they score an average of 29.2 points per game.

On defense, the Bills sit 14th in the league, allowing 22.9 points per game. They concede an average of 5.4 yards per rushing attempt and 153.0 rushing yards each game this season. In the passing game, they’ve allowed 1,697 yards, ranking them 2nd in the league, with an average of 169.7 passing yards allowed per game and a completion rate of 61.8%. Overall, they give up 322.7 total yards per game, ranking them 12th in the league. They have surrendered 10 passing touchdowns and 17 rushing touchdowns, totaling 1,530 rushing yards allowed over 10 games this season.

The Texans are entering the field with a balanced record of 5-5. In their previous match, they narrowly defeated the Tennessee Titans with a score of 16-13. Woody Marks carried the ball 18 times for 44 yards, averaging 2.4 yards per attempt. Nico Collins emerged as a key target, catching 9 passes for 92 yards (10.2 yards per catch). Quarterback Davis Mills threw for 274 yards on 26 of 41 passing, securing 1 touchdown and a QB rating of 90.9, without any interceptions. The Texans gave up 58 rushing yards on 17 attempts, averaging 3.4 yards per carry. The secondary faced 37 passing attempts, allowing 24 completions for 171 yards with a completion percentage of 64.9%. Houston played 64 offensive snaps and finished the game with 315 total yards while gaining 3.3 yards per rushing attempt.

The Houston Texans average 329.6 yards per game, placing them 19th in the league. They accrue 107.6 rushing yards per game, totaling 1,076 yards this season. With 6 interceptions and 3 lost fumbles, they’ve generated 116 first downs. Their offense has been penalized 72 times, costing them 589 yards, ranking them 12th in the league in this category. The Texans have thrown for 2,220 yards this season, averaging 222.0 yards per game, positioning them 16th overall. In terms of scoring, the Texans rank 21st in the league, averaging 22.0 points per contest.

Defensively, the Texans are strong, allowing just 16.3 points per game, making them 1st in the league. They have given up 10 passing touchdowns and 171.0 passing yards per game, ranking them 3rd in football. Houston has permitted 871 rushing yards (87.1 yards per game), along with 8 rushing touchdowns this season. Their defense has been on the field for 565 plays, ranked 2nd in the league, and they have forced 16 turnovers (6 fumbles and 10 interceptions) throughout the year, surrendering a total of 163 points.

Who will emerge victorious in tonight’s Bills versus Texans matchup against the spread?

Choice: Bet on the Bills -5.5

Some links on this page are affiliate links. If you sign up or make a purchase through them, we may earn a small commission always at no extra cost to you. Thanks for helping us keep this site running.

Pick: Buffalo Bills -5.5
Bet Now

Leave a Reply

Your email address will not be published. Required fields are marked *

New Bookmakers
Bet99

Proud Partner of the NHL + Excellent live betting

 

Betway

Widest Range of Betting Options + Robust in-play with streaming

BetMGM

Top-Rated Betting App in Ontario with Live streaming & Cash-out

Sports Interaction

Crafted for Canada’s Bettors. Best Odds For NHL, CFL & NFL

© 2025 BettingEdge.ca. All Rights Reserved. BettingEdge.ca is your trusted source for Canadian sportsbook reviews, betting tips, and responsible gaming resources. Must be 19+ to bet. Play responsibly.