Chicago White Sox vs Cleveland Guardians Preview, 9/14/2025 MLB Predictions, Top Picks & Betting Odds

Home » Chicago White Sox vs Cleveland Guardians Preview, 9/14/2025 MLB Predictions, Top Picks & Betting Odds

Matchup: Chicago White Sox vs Cleveland Guardians

Scheduled Date: Sunday, September 14, 2025

Venue: Progressive Field, Cleveland, OH

Broadcast: CLEGuardians.TV

Betting Odds: Chicago (+102) Cleveland (-122)

The Cleveland Guardians (75-71) are set to host the Chicago White Sox (57-90) at Progressive Field this Sunday. The betting line shows Chicago at +102 and Cleveland at -122, with an over/under established at 8 runs. Expected starting pitchers for this game are Yoendrys Gomez and Slade Cecconi.

MLB predictions and best bet from Angel Martinez on Cleveland Guardians

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This season, the White Sox have hit 228 doubles and launched 150 home runs. Chicago boasts a slugging percentage of .378, with 1,226 strikeouts and 461 walks recorded. As a team, they average 4.1 runs per game, placing them 26th in the league. With 577 RBIs and 1,153 hits, their batting average stands at .236. They have scored a total of 597 runs, achieving an on-base percentage of .305.

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The White Sox maintain a strikeout-to-walk ratio of 2.11 and their collective WHIP is 1.36. The pitching staff has surrendered 166 home runs and a total of 673 runs (21st in the league). They allowed 1,211 hits (8.5 per 9 innings) and 604 earned runs, giving the White Sox a team ERA of 4.22 (20th overall), with 1,147 strikeouts recorded. They have issued 544 walks, resulting in a FIP of 4.47 this season.

The White Sox bullpen has come to the mound with runners on 148 occasions and has appeared in high-leverage situations 141 times. This relief squad holds 64 holds this year, ranking 27th in baseball. Their save percentage stands at 52.3%, with 110 save opportunities leading to 23 successful saves and 21 blown saves. Additionally, the bullpen has inherited 215 runners, with 32.1% scoring. Chicago has utilized 479 relievers throughout the season.

Of the 11,586 defensive innings played, the White Sox have converted 69.7% of balls in play into outs, ranking them 17th in the league. They have tallied 3,862 putouts, 1,168 assists, and 95 errors, resulting in a fielding percentage of .981, which currently places them 28th in professional baseball. The team has also executed 118 double plays.

In his brief career, Gomez, with a 3-2 win-loss record, possesses a FIP of 4.64 after facing 275 hitters. He has allowed 56 hits (averaging 8.5 hits per nine innings) alongside 33 walks. His ERA stands at 4.71 (31 earned runs), and his WHIP is 1.503. Throughout 59 innings pitched, Gomez has accrued 59 strikeouts.

The Cleveland Guardians feature a .296 on-base percentage and a .225 batting average this season. They have struck out 1,209 times (17th in the league) and have contributed 1,077 hits. With 149 home runs and 550 RBIs, the Guardians have registered a slugging percentage of .369 and average 3.90 runs per game (27th in MLB). They have recorded 213 doubles and have walked 445 times for a total of 570 runs.

As a unit, the Guardians have a WHIP of 1.301 and a FIP of 4.10 this season. Their strikeout-to-walk ratio stands at 8.40 (1,206 strikeouts against 495 walks). Currently, they rank 14th in the league for total hits allowed, with 1,192, and have allowed 156 home runs while giving up 4.22 runs per nine innings (11th in MLB). Cleveland’s pitching staff has surrendered a total of 608 runs and maintained a team ERA of 3.86 from 556 earned runs.

The Guardians’ bullpen pitchers have inherited 188 runners, with 33.5% of those scoring. This season, they have entered the game during high-leverage situations 168 times, with 135 appearances having runners on. The Guardians have had 160 save opportunities, accruing 95 holds against 19 blown saves. They rank fourth in the league with a save rate of 69.4%, utilizing 479 bullpen pitchers this year. Cleveland has converted 43 of 62 save chances.

The Guardians also boast 112 double plays and hold a .983 fielding percentage (27th in MLB). They have recorded 1,204 assists, 89 errors, and 3,891 putouts throughout the season. Their defensive efficiency stands at 69.6% over 11,673 innings, placing them 19th in professional baseball.

Cecconi has allowed 234 hits over his career while recording 178 strikeouts across 219 innings pitched. He has surrendered a total of 127 earned runs, with a WHIP of 1.296 and a FIP of 5.1. His strikeout-to-walk ratio is 3.56 after facing 932 hitters. Cecconi holds an 8-14 career win-loss record and an earned run average of 5.22, allowing 9.6 hits per nine innings.

Who will prevail in today’s MLB matchup against the spread or moneyline?

Tony Sink’s Prediction: Opt for Chicago (+102)

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