- Matchup: Cincinnati Bengals vs Buffalo Bills
- Date: Sunday, December 7, 2025
- Venue: Highmark Stadium, Orchard Park, NY
- Broadcast: FOX
- Betting Odds: Bills favored by 5.5 points
- Total Points Over/Under: 52.5
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Highmark Stadium will host the clash between the Buffalo Bills (8-4) and the Cincinnati Bengals (4-8) this Sunday. Cincinnati enters the game as 5.5-point underdogs, with a total set at 52.5.
The Cincinnati Bengals come into this matchup with a 4-8 record this season. In their previous game, they emerged victorious against the Baltimore Ravens with a score of 32-14. Quarterback Joe Burrow completed 24 of 46 passes for 261 yards and 2 touchdowns, posting a QB rating of 83.7 without any interceptions. Ja’Marr Chase showcased his skills with 110 yards on 7 receptions, averaging 15.7 yards per catch. On the ground, Chase Brown led with 15 carries, gaining 78 yards (5.2 yards per carry). The Bengals executed 79 plays, amassing a total of 382 yards. They managed to run the ball 33 times, collecting 128 rushing yards for an average of 3.9 yards per attempt. Defensively, they allowed 123 rushing yards on 22 attempts (5.6 yards per carry) and permitted 17 completions on 32 passes for 223 yards, achieving a completion rate of 53.1%.

Throughout the season, the Bengals have recorded a total of 3,760 offensive yards. They have notched 136 first downs and incurred 67 penalties totaling 485 yards. In terms of scoring, the team has produced 23 passing touchdowns and 5 rushing touchdowns. However, they have also committed 18 turnovers (12 interceptions and 6 fumbles lost). The Bengals average 88.5 rushing yards per game, ranking them 30th in the NFL, and have an average of 23.3 points per game.
Defensively, Cincinnati ranks last in the NFL, conceding 31.2 points per game. They allow 5.1 yards per carry, yielding an average of 153.3 rushing yards each game. In the passing department, they have allowed 3,081 yards this season, ranking 32nd in the league, and giving up 256.8 passing yards per game while allowing a completion rate of 65.7%. Overall, they are permitting 410.0 yards per game, also last in the NFL, featuring 26 passing touchdowns and 14 rushing touchdowns against them. In total, they have conceded 1,839 rushing yards over 12 games.
The Buffalo Bills enter the game with an 8-4 season record. They last played against the Pittsburgh Steelers, securing a win with a score of 26-7. Josh Allen threw for 123 yards on 15 completions out of 23 attempts, achieving a QB rating of 75.1 with one touchdown and one interception. James Cook was a notable player, catching 3 passes for 33 yards (11.0 yards per reception) while rushing 32 times for 144 yards, averaging 4.5 yards per carry. The Bills totaled 372 offensive yards, executing 74 plays at an average of 5.0 yards per play. They averaged 4.9 yards per carry with 249 rushing yards on 51 attempts. Buffalo’s defense granted 58 rushing yards on 18 carries (3.2 yards per attempt) and allowed a completion rate of 41.7%, giving up 108 yards on 10 of 24 passing attempts.
The Bills’ offense averages 381.0 yards per game, ranking 2nd in the NFL. They achieve 155.7 rushing yards per game and have accumulated 1,868 rushing yards this season. The team has committed 10 interceptions and lost 7 fumbles, while securing 139 first downs collectively. Buffalo’s offensive unit has conceded 662 total yards from penalties, ranking them 17th in the league in that regard. They have passed for a total of 2,704 yards this season, averaging 225.3 passing yards per game, placing them 10th in the NFL. In terms of scoring, the Bills rank 5th, averaging 28.1 points per game.
On the defensive side, the Bills allow 21.6 points per game, placing them 13th in the league. They have given up 12 passing touchdowns and permit 163.2 passing yards per game, ranking 1st in the NFL in that statistic. Buffalo has surrendered a total of 1,696 rushing yards this season (141.3 yards per game), along with conceding 18 rushing touchdowns. The Bills’ defense has participated in 679 plays from scrimmage, ranking 3rd in the league, and created 15 turnovers (7 fumbles forced and 8 interceptions) throughout the season, allowing a cumulative total of 259 points.
Which team will prevail in the Bengals vs. Bills game against the spread?
Prediction: Take the Bengals +5.5
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