Cincinnati Reds vs San Diego Padres Prediction, MLB Picks, Best Bets & Odds for 9/10/2025

Home » Cincinnati Reds vs San Diego Padres Prediction, MLB Picks, Best Bets & Odds for 9/10/2025

Matchup: Cincinnati Reds vs. San Diego Padres

Date: Wednesday, September 10, 2025

Venue: Petco Park, San Diego, CA

Broadcast: Padres.TV

Betting Odds: Cincinnati (+220) San Diego (-275)

The San Diego Padres, currently holding a record of 79-65, will host the Cincinnati Reds, who stand at 72-72, at Petco Park this Wednesday. The odds for this matchup see the Reds at +220 and the Padres at -275, with an over/under set at 8 runs. The starting pitchers are expected to be Andrew Abbott for Cincinnati and Nick Pivetta for San Diego.

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The Cincinnati Reds have achieved 233 doubles and hit 143 home runs this season. With a slugging percentage of .392, the team has struck out 1,256 times and earned 470 walks. Averaging 4.5 runs per game places them 13th in the league. This season, they’ve racked up 614 RBIs and 1,199 hits, resulting in a batting average of .247 and an on-base percentage of .317.

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The Reds illustrate a team ERA of 3.94 this season (16th in the league) with 1,224 strikeouts recorded. Cincinnati’s pitchers have allowed 170 home runs and a total of 621 runs (16th in MLB). They have issued 451 walks, resulting in a FIP of 4.15 over the season. The team has given up 1,139 hits (8.0 per 9 innings) alongside 559 earned runs. Their strikeout-to-walk ratio stands at 2.71, while holding a combined WHIP of 1.25.

Reds bullpen pitchers have faced opposition with runners on base 130 times this season, contributing to 150 appearances in high-leverage situations. Their relievers have secured 91 holds this year (6th in MLB) and a save percentage of 61.1%, entering 147 save opportunities with 33 successful saves and 21 blown saves. Out of 193 inherited runners, 33.2% have scored. A total of 495 relievers have taken the mound for Cincinnati this season.

The Reds have converted 70.7% of balls in play into outs over 11,484 innings, ranking 6th in MLB. This season, they have attained 3,828 putouts, 1,092 assists, and committed 82 errors, resulting in a .984 fielding percentage that ranks 25th in the league. Additionally, they have successfully turned 92 double plays.

Starting pitcher Andrew Abbott has logged 390 innings with 364 strikeouts in his career. His earned run average stands at 3.46 (150 earned runs allowed) and a WHIP of 1.250. He has given up 352 hits (averaging 8.1 hits per nine innings) and 136 walks. With a win-loss record of 26-22, Abbott’s FIP is 3.41 after facing 1,636 batters in Major League Baseball.

The San Diego Padres procure a .322 on-base percentage and a .252 batting average this season. They have struck out 1,022 times (28th in the league) and accumulated 1,217 total hits. The Padres have homered 127 times this season and collected 577 RBIs. With a slugging percentage of .387, they score an average of 4.26 runs per game (22nd in MLB), totaling 236 doubles and 463 walks, leading to 614 runs scored.

San Diego’s pitching staff has surrendered 559 runs this season, achieving a 3.66 team ERA (517 earned runs). They have allowed 154 home runs and permit 3.96 runs per 9 innings, ranking 4th in MLB. As a collective, they own a WHIP of 1.212 and a team FIP of 4.01. The strikeout-to-walk ratio sits at 8.80 (1,245 strikeouts versus 474 walks), leading the league in total hits allowed with 1,068.

Padres relievers have an inherited scoring percentage of 28.8% from 233 inherited runners. They have made 191 appearances in high-leverage situations and 164 times with runners on base. With 155 save opportunities, San Diego’s relievers have managed 91 holds and 15 blown saves, boasting the best save percentage of 74.6%, having used 510 relief pitchers this season. In 59 save opportunities, they have achieved 44 successful saves.

The San Diego Padres have turned 105 double plays this season, maintaining a fielding percentage of .987 (13th in professional baseball). This season has seen them accumulate 1,088 assists, 66 errors, and 3,816 putouts. Over their 11,448 defensive innings, the Padres exhibit a defensive efficiency of 71.7% (2nd in professional baseball).

In his MLB career, Pivetta has allowed 1,092 hits and accumulated 1,311 strikeouts in 1,193 innings pitched. He has given up 596 earned runs, holding a WHIP of 1.268, and possesses a FIP of 4.4. His strikeout-to-walk ratio is 3.11, having faced 5,035 opponents throughout his career. Pivetta’s career record stands at 69-76 with an ERA of 4.50, permitting 8.2 hits per 9 innings.

Who will clinch the victory in tonight’s MLB game against the spread or moneyline?

Guy Bruhn’s Prediction: Back Cincinnati (+220)

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