Cleveland Guardians vs Boston Red Sox Prediction for 9/1/2025 MLB Picks, Best Bets & Odds

Home » Cleveland Guardians vs Boston Red Sox Prediction for 9/1/2025 MLB Picks, Best Bets & Odds

Matchup: Cleveland Guardians vs Boston Red Sox

Date: Monday, September 1, 2025

Venue: Fenway Park, Boston, MA

Broadcast: NESN

Betting Odds: Cleveland (+110) Boston (-130)

On Monday, September 1, 2025, Fenway Park will host a thrilling contest between the Boston Red Sox (75-60) and the Cleveland Guardians (66-66). In this matchup, the Guardians are positioned at +110 on the moneyline, while the Red Sox are set at -130. The over/under for this game stands at 8 runs, with Slade Cecconi and Brayan Bello expected to take the mound.

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The Cleveland Guardians have struggled this season, averaging 3.9 runs per game, ranking them 28th in the league. With 508 runs scored and an on-base percentage of .295, the Guardians have also hit 189 doubles and 133 home runs. They have a total of 489 RBIs and 966 hits, with a batting average of .224. Cleveland’s slugging percentage is .366, and they have struck out 1,093 times while walking 407 times.

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The Guardians’ pitchers have a K/BB ratio of 2.38 and a team WHIP of 1.31. They have surrendered 145 home runs and a total of 563 runs (14th in MLB). The Cleveland pitching staff has allowed 1,077 hits (8.3 hits per 9 innings) and 512 earned runs, resulting in an earned run average (ERA) of 3.93 (13th in MLB). They have recorded 1,099 strikeouts while walking 461 batters, with a FIP of 4.14 for the season.

Cleveland’s relief pitchers have made 441 appearances this season, inheriting 170 runners, with 33.5% scoring. They have notched 38 saves out of 56 opportunities, achieving a save percentage of 67.9% in 150 save situations. The Guardians’ bullpen ranks 3rd in the league with 91 holds, stepping in with runners on base 122 times and having 153 high-pressure appearances.

In the field, the Guardians have turned 69.6% of balls in play into outs across 10,566 innings, ranking them 19th in the league. The Cincinnati Reds have compiled 3,522 putouts, 1,076 assists, and 86 errors, holding a fielding percentage of .982 (28th in baseball) and have turned 95 double plays.

Slade Cecconi has pitched 206 innings, accumulating 167 strikeouts throughout his career. With a 7-14 win-loss record, he has a FIP of 5.16 and has faced 879 batters. Cecconi’s earned run average stands at 5.24 (120 earned runs) and he has a WHIP of 1.306, allowing 222 hits (9.7 per nine innings) with 47 walks.

The Boston Red Sox have a team on-base percentage of .323 and a batting average of .252 this season. They have accumulated 1,167 hits, striking out 1,192 times (4th in baseball). With 163 home runs and 638 RBIs, Boston’s slugging percentage is .425, averaging 4.95 runs per game (5th in MLB). They have recorded 271 doubles and drawn 441 walks, scoring a total of 668 runs.

Boston’s pitching staff has given up 560 runs this season, with an ERA of 3.66 (491 earned runs). The Red Sox have allowed 137 home runs and average 4.17 runs per nine innings (9th in MLB). Their team WHIP is 1.279, and their FIP stands at 4.00. They have a K/BB ratio of 8.30, with 1,116 strikeouts against 439 walks, ranking them 17th in the league for total hits allowed (1,107).

With 135 save opportunities, the Red Sox have achieved 72 holds and recorded 23 blown saves. They have converted 38 saves out of 61 chances, with relievers entering 165 times in high-leverage situations and 134 appearances with runners on. Boston’s relievers have a 30.9% inherited score rate, ranking 19th in the league with a 62.3% save percentage.

In 10,800 innings played, the Red Sox have a defensive efficiency rating of 69.3% (21st in the league). They have turned 107 double plays and maintain a fielding percentage of .980 (29th in MLB). For the season, Boston has recorded 1,228 assists, 101 errors, and 3,600 putouts.

Brayan Bello has given up 521 hits in his career and has achieved 448 strikeouts over 517 innings pitched. With a career record of 38-33, Bello has an ERA of 4.04 and allows 9.1 hits per nine innings. He has given up 232 earned runs, registering a WHIP of 1.361 and a FIP of 4.0. His K/BB ratio stands at 2.45, facing 2,226 batters in his MLB tenure.

Which team will prevail in tonight’s MLB showdown against the spread or moneyline?

Josh Schonwald’s Prediction: Choose Cleveland (+110)

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