Cleveland Guardians vs Boston Red Sox Prediction for 9/2/2025: MLB Picks, Best Bets & Odds

Home » Cleveland Guardians vs Boston Red Sox Prediction for 9/2/2025: MLB Picks, Best Bets & Odds

Matchup: Cleveland Guardians vs. Boston Red Sox

Scheduled Date: Tuesday, September 2, 2025

Venue: Fenway Park, Boston, MA

Broadcast: NESN

Betting Odds: Cleveland (+132) Boston (-160)

The Boston Red Sox (75-62) will face off against the Cleveland Guardians (68-66) at Fenway Park this Tuesday. The betting line for this matchup places Cleveland at +132, while Boston opens at -160. The over/under for runs scored is set at 8.5. Slade Cecconi and Brayan Bello are the starting pitchers anticipated for the game.

MLB Predictions: Jose Ramirez, Cleveland Guardians

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As a collective, the Cleveland Guardians are averaging 3.9 runs per game, ranking them 28th in Major League Baseball. The team has scored a total of 517 runs with an on-base percentage (OBP) of .295. They have recorded 191 doubles and hit 136 home runs, totaling 498 runs batted in (RBIs) with an overall batting average of .224. The Guardians’ slugging percentage is .367, with 1,109 strikeouts and 412 walks this season.

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The Guardians’ strikeout-to-walk ratio stands at 2.39 with a WHIP (walks plus hits per inning pitched) of 1.31. Their pitchers have allowed 148 home runs and 570 runs this season, which ranks them 11th in the league. Cleveland’s pitching staff has given up 1,092 hits (averaging 8.2 hits per nine innings) and 519 earned runs. With a team ERA of 3.92, they’re positioned 14th in MLB, also having recorded 1,117 strikeouts. The team has walked 467 batters, with a FIP (fielding independent pitching) of 4.15 throughout the season.

This year, the Guardians have utilized 445 relief pitchers. Their bullpen has inherited 170 runners, with 33.5% scoring. They have secured 39 saves out of 57 opportunities, resulting in a save percentage of 68.4% while entering 152 save scenarios. The bullpen has tallied 92 holds, ranking 3rd in the league. Guardians relievers have appeared on the mound with runners on base 122 times in high leverage situations.

Defensively, the Guardians have converted 69.6% of balls put in play into outs, placing them 19th in MLB. The team has a total of 3,576 putouts this season, along with 1,094 assists and 86 errors, resulting in a fielding percentage of .982, ranking them 27th in the league. They have turned 98 double plays this year.

Slade Cecconi has pitched 206 innings in his career, accumulating 167 strikeouts. He holds an ERA of 5.24, having allowed 120 earned runs with a WHIP of 1.306. Over his career, he has given up 222 hits, averaging 9.7 hits per nine innings, along with 47 walks. With a career record of 7-14, his FIP stands at 5.16, having faced 879 batters in the majors.

The Boston Red Sox maintain a team slugging percentage of .424, averaging 4.91 runs per game, placing them 6th in the league. They have amassed 272 doubles while walking 446 times, leading to a total of 673 runs. Boston has registered 165 home runs and 642 RBIs this season, with 1,209 strikeouts (4th in the league) and 1,184 hits. Their season averages include a .323 OBP and a .252 batting average.

Boston’s pitching staff has a WHIP of 1.287 and a FIP of 3.99. Their strikeout-to-walk ratio is 8.30, with 1,136 strikeouts compared to 450 walks. As a unit, they rank 19th in total hits allowed, conceding 1,129. The Red Sox have given up 138 home runs and allow 4.21 runs per 9 innings, positioning them 9th in the league. Their season ERA is 3.70, having allowed 574 runs (504 earned runs).

In relief, Boston’s bullpen has inherited 32.1% of their 184 base runners. They have pitched in 166 high leverage situations and faced base runners 137 times. Out of 136 save opportunities this season, they have achieved 72 holds and experienced 24 blown saves. Their save percentage of 61.3% ranks them 20th in MLB, with 448 relievers deployed on the mound this year. The Red Sox have successfully converted 38 of their 62 save chances.

Currently, the Boston Red Sox stand at 69.1% defensive efficiency, placing them 23rd in MLB over 11,043 innings played. They have turned 112 double plays and carry a fielding percentage of .980, positioning themselves 29th in professional baseball. This season, they have achieved 1,254 assists, committed 103 errors, and tallied 3,681 putouts.

Brayan Bello, with a career record of 38-33, boasts a 4.04 ERA and allows 9.1 hits per nine innings. His strikeout-to-walk ratio is 2.45, facing 2,226 batters throughout his career. Bello has conceded 232 earned runs, holding a WHIP of 1.361 and a FIP of 4.0. In total, he has allowed 521 hits and amassed 448 strikeouts over 517 innings pitched in the Major Leagues.

Who will come out on top in tonight’s MLB showdown—against the spread or via the moneyline?

Josh Schonwald’s Prediction: Bet on Cleveland (+132)

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