Cleveland Guardians vs Tampa Bay Rays Prediction for 9/5/2025 MLB Picks, Best Bets & Odds

Home » Cleveland Guardians vs Tampa Bay Rays Prediction for 9/5/2025 MLB Picks, Best Bets & Odds

Matchup: Cleveland Guardians vs Tampa Bay Rays

Date: Friday, September 5, 2025

Venue: George M. Steinbrenner Field, Tampa, FL

Broadcast: FanDuel Sports Network Sun

Odds/Point Spread: Cleveland (+162), Tampa Bay (-196)

The Tampa Bay Rays (70-69) are set to face off against the Cleveland Guardians (69-69) at George M. Steinbrenner Field this Friday. The current betting odds indicate Cleveland at +162 and Tampa Bay at -196, with the total runs expected to be 8. Gavin Williams and Ian Seymour are the likely starting pitchers for this matchup.

MLB Predictions: Richie Palacios and Tampa Bay Rays

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As a team, the Cleveland Guardians are scoring an average of 3.9 runs per game, placing them 27th in the league. They have accumulated a total of 538 runs with an on-base percentage of .294. The Guardians have recorded 198 doubles and hit 143 home runs this season. Their total RBIs stand at 517, alongside 1,012 hits and a batting average of .224. Cleveland’s slugging percentage is .369, and they have struck out 1,135 times while drawing walks 419 times.

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The Guardians currently boast a team ERA of 3.97, ranking 16th in the league. They have struck out 1,149 batters this season and given up 152 home runs, with a total of 592 runs allowed (11th in the league). The pitching staff has issued 477 walks, resulting in a collective FIP of 4.16. Cleveland has allowed 1,140 hits (averaging 8.4 per 9 innings) and 541 earned runs. Their strikeout-to-walk ratio is 2.41, and the team has a WHIP of 1.32.

Guardians relievers have entered 129 times with opponents on base and participated in 159 high-leverage situations, achieving 92 holds this year (5th in the league). With a save rate of 68.4%, they have emerged for 152 save opportunities this season, securing 39 saves while blowing 18 of 57 chances. The bullpen has inherited 181 runners, with 33.1% of them allowing a run. Cleveland has deployed 458 relief pitchers this year.

The Guardians have converted 69.3% of balls in play to outs across 11,034 innings, ranking them 19th in MLB. They have recorded 3,678 putouts, 1,126 assists, and committed 86 errors this season, resulting in a fielding percentage of .982, placing them 27th in MLB with 102 double plays.

Gavin Williams has pitched a total of 301 innings in his MLB career, striking out 303 batters. With a career record of 15-20, Williams has a FIP of 3.62 and faced 1,283 hitters. His ERA stands at 3.68 (allowing 123 earned runs), alongside a WHIP of 1.301. He has given up 250 hits (7.5 hits per nine innings) and issued 142 walks.

The Tampa Bay Rays have tallied 157 home runs this year, along with 604 RBIs. They have amassed 212 doubles, walked 399 times, and scored 636 runs so far. The team has an on-base percentage of .314 and a batting average of .253, with a slugging percentage of .404. The Rays score an average of 4.58 runs per game, ranking 11th in the league. They have struck out 1,189 times (13th in the league) and recorded 1,187 hits.

On the pitching side, Tampa Bay has allowed 575 runs this season with a team ERA of 3.89, including 532 earned runs. They have surrendered 182 home runs and allowed 4.20 runs per 9 innings (9th in MLB). The Rays hold a WHIP of 1.209 and a FIP of 4.21. Their K/BB ratio stands at 8.80, with 1,203 strikeouts against 398 walks, placing them 6th in the league for total hits allowed with 1,090.

Tampa Bay’s bullpen has been called upon 55 times for save opportunities, successfully converting 32 saves, ranking them 25th in the league with a save rate of 58.2%. This season, they have used 436 relievers, with 131 entering in high-leverage situations and 96 with runners on base. The Rays’ bullpen has allowed runs to score from 31.5% of the 143 inherited runners. With 135 save situations, they have achieved 78 holds and recorded 23 blown saves.

The Tampa Bay Rays have executed 128 double plays and recorded a fielding percentage of .987 (9th in MLB). They have compiled 1,225 assists, committed 64 errors, and achieved 3,694 putouts in 11,082 defensive innings, showcasing a defensive efficiency of 70.9% (4th in MLB).

Ian Seymour, with a career record of 3-0, has an impressive 2.99 ERA, allowing 6.5 hits per 9 innings pitched. He has achieved a K/BB ratio of 4.20 and faced 135 hitters to date. In his MLB career, he has given up a total of 11 earned runs, with a WHIP of 1.027 and a FIP of 2.9. Seymour has surrendered 24 hits while recording 42 strikeouts in 33 innings.

Who will triumph in tonight’s MLB contest against the spread or moneyline?

Tony Sink’s Prediction: Bet on Tampa Bay (-196)

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