Duke Blue Devils vs Syracuse Orange Prediction for College Football Picks, Best Bets & Odds on 9/27/2025

Home » Duke Blue Devils vs Syracuse Orange Prediction for College Football Picks, Best Bets & Odds on 9/27/2025
  • Matchup: Duke Blue Devils vs Syracuse Orange
  • Scheduled Date: Saturday, September 27, 2025
  • Venue: JMA Wireless Dome, Syracuse, NY
  • Broadcast: ACC Network
  • Betting Odds: Orange (+5.0)
  • Over/Under Total: 60.5

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On September 27, 2025, the Syracuse Orange (3-1) will face off against the Duke Blue Devils (2-2) at the JMA Wireless Dome. Duke enters the contest as 5.0-point favorites according to betting lines, with the total set at 60.5 points.

The Duke Blue Devils carry a 2-2 record into this game. In their previous matchup, they triumphed over the NC State Wolfpack with a score of 45-33. The Blue Devils executed 63 plays for a total of 418 yards in that game. On the ground, they carried the ball 35 times for 149 yards, averaging 4.3 yards per carry. Defensively, Duke allowed 171 rushing yards on 35 attempts, averaging 4.9 yards per carry. Through the air, the Blue Devils conceded 29 completions on 39 attempts resulting in 364 yards and a completion rate of 74.4%.

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This season, Duke has amassed a total of 1,856 yards, scoring 11 touchdowns through the air and 5 on the ground, while turning the ball over 7 times. They have successfully achieved 93 first downs and committed 26 penalties for a total of 272 yards. The team currently averages 132.3 rushing yards per game, ranking 99th nationally. Overall, the Blue Devils score an average of 34.0 points per game.

On the defensive side, Duke has allowed 1,042 passing yards, placing them 116th in Division I, with an average of 260.5 passing yards conceded per game and a completion percentage of 70.0%. Overall, they’ve given up 413.8 yards per game, ranking 113th in college football. They yield 5 touchdowns through the air and 12 on the ground, surrendering an average of 3.9 yards per rush and 153.3 rushing yards per game. To date, they’ve allowed a total of 613 rushing yards across 4 games, earning a rank of 117th nationally in opponent scoring with 32.3 points allowed per game.

The Syracuse Orange head into this contest with a 3-1 record. In their most recent game, they secured a 34-21 victory over the Clemson Tigers. Syracuse rushed for an average of 4.1 yards per carry, totaling 155 yards on 38 attempts. They managed 433 total yards and ran 77 plays for an average of 5.6 yards per play. On the pass defense front, Syracuse allowed a completion percentage of 60.7%, giving up 363 yards on 37 completions out of 61 attempts. They also conceded 140 rushing yards on 22 attempts at an average of 6.4 yards per carry.

In terms of scoring, Syracuse ranks 33rd in Division I with an average of 38.3 points per game. They average 472.8 yards per contest, good for 23rd nationally. Syracuse has accrued 175 penalty yards on 21 infractions, ranking them 78th in the nation for penalizing themselves. They have thrown 3 interceptions and allowed opponents to recover 3 fumbles while recording 104 first downs. This season, the Orange have racked up 1,415 passing yards, averaging 353.8 yards per game, which places them 4th in Division I. Rushing-wise, they average 119.0 yards per game with a total of 476 rushing yards so far.

Defensively, Syracuse gives up 27.5 points per game, placing them 99th in the country. They have allowed a total of 635 rushing yards this season, averaging 158.8 yards per game, and given up 4 rushing touchdowns. In the passing game, they’ve conceded 9 touchdowns and an average of 296.3 passing yards per outing, ranking them 134th in Division I. Their defense has been on the field for 312 plays, ranking them 135th in the division. So far this year, they have collected 3 fumble recoveries and 3 interceptions, conceding a total of 110 points.

Who do you think will win the matchup between the Blue Devils and Orange tonight?

Expert Prediction: Bet on the Blue Devils -5.0

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Pick: Duke Blue Devils -5.0
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