Indiana Hoosiers vs Iowa Hawkeyes Prediction for College Football Picks, Best Bets & Odds on 9/27/2025

Home » Indiana Hoosiers vs Iowa Hawkeyes Prediction for College Football Picks, Best Bets & Odds on 9/27/2025
  • Matchup: Indiana Hoosiers vs. Iowa Hawkeyes
  • Date: Saturday, September 27, 2025
  • Venue: Kinnick Stadium, Iowa City, IA
  • Broadcast: Peacock
  • Odds/Point Spread: Hawkeyes (+7.0)
  • Total/Over-Under: 48

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This Saturday, September 27, 2025, the Iowa Hawkeyes (3-1) host the undefeated Indiana Hoosiers (4-0) at Kinnick Stadium. The Hoosiers enter this contest as 7.0-point favorites, with a total set at 48.

The Indiana Hoosiers boast a perfect 4-0 record this season. In their last appearance, they convincingly defeated the Illinois Fighting Illini, finishing with a score of 63-10. In terms of defensive performance on the line of scrimmage, the Hoosiers allowed just 2 yards on 20 rushing attempts, averaging an impressive 0.1 yards per carry against. They allowed 16 completions on 25 attempts through the air for 159 yards, resulting in a completion percentage of 64.0%. The Hoosiers executed 72 plays, accumulating 579 total yards, with 49 rushing attempts yielding 312 yards—averaging 6.4 yards per carry.

College Football Predictions: Kamari Moulton Iowa Hawkeyes Best Bets

Overall, the Hoosiers have amassed 2,354 total yards this season. Their touchdown distribution includes 17 through the air and 11 on the ground, with only 1 turnover committed. Indiana has achieved 122 first downs while being penalized 15 times for 120 yards. They average 308.8 rushing yards per game, placing them 3rd nationally. The Indiana Hoosiers also average an impressive 54.8 points per game.

Defensively, Indiana ranks 5th in the nation for points allowed, limiting opponents to just 8.3 points per game. Enemies are averaging 3.3 yards per carry and 87.0 rushing yards per game, with a total of 348 rushing yards surrendered across 4 games. In the pass defense category, they’ve conceded 475 yards (ranking 13th nationally), allowing an average of 118.8 yards per game, with a completion rate of 58.2%. This season, they’ve permitted only 1 passing touchdown and 2 rushing touchdowns.

The Iowa Hawkeyes enter this matchup with a record of 3-1. In their most recent game, they secured a 38-28 victory against the Rutgers Scarlet Knights. Iowa compiled 346 total yards on 56 plays, averaging 6.2 yards per play. They rushed for 160 yards on 38 attempts, averaging 4.2 yards per carry. Defensively, the Hawkeyes held their opponent to 30 rushing attempts for just 70 yards (2.3 yards per carry). Their pass defense allowed a completion rate of 60.0%, giving up 330 yards on 24 completions out of 40 attempts.

In terms of offensive production, the Hawkeyes rank 54th in FBS, averaging 33.0 points per game. They accumulate around 338.3 yards per game, placing them 106th. The Iowa offense has recorded 93 penalty yards through 9 infractions, putting them 134th nationally for penalties. This season, they’ve thrown 1 interception and committed 1 fumble, gaining 80 first downs. The Hawkeyes have totaled 551 passing yards, averaging 137.8 yards per game, ranking 129th. However, they are more proficient in the ground game, averaging 200.5 rushing yards per game and totaling 802 rushing yards so far.

On the defensive side, Iowa is giving up 14.5 points per game, ranking them 24th in FBS. They have allowed a total of 243 rushing yards (60.8 yards per game) along with 5 rushing touchdowns this season. Their pass defense has allowed 2 touchdowns and 172.8 yards per game, placing them 32nd nationally. The Hawkeyes’ defense has participated in 223 plays, ranking 42nd in FBS, resulting in 1 fumble and 1 interception recorded so far, yielding a total of 58 points allowed.

Who will emerge victorious in this thrilling matchup between the Hoosiers and Hawkeyes?

Expert Pick: Choose the Hoosiers -7.0

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Pick: Indiana Hoosiers -7.0
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