Indiana Hoosiers vs Ohio State Buckeyes Predictions for 12/6/2025 College Football, Picks, Best Bets & Odds

Home » Indiana Hoosiers vs Ohio State Buckeyes Predictions for 12/6/2025 College Football, Picks, Best Bets & Odds

  • Matchup: Indiana Hoosiers vs Ohio State Buckeyes
  • Event Date: Saturday, December 6, 2025
  • Venue: Lucas Oil Stadium, Indianapolis, IN
  • Broadcast: FOX
  • Betting Line: Buckeyes favored by 4.0 points
  • Total Points: 47.5

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On Saturday, December 6, 2025, the Ohio State Buckeyes (12-0) will face off against the Indiana Hoosiers (12-0) at Lucas Oil Stadium during the thrilling Big Ten Championship. The Hoosiers enter as 4.0-point underdogs, with the total set at 47.5 points.

The Indiana Hoosiers come into this contest with an impressive 12-0 record for the season. In their latest outing, they dominated the Purdue Boilermakers, securing a convincing 56-3 victory. On the defensive front, Indiana allowed just 44 rushing yards on 27 attempts, averaging 1.6 yards per carry. Through the air, they permitted 25 completions out of 47 attempts, totaling 238 yards with a completion rate of 53.2%. The Hoosiers executed 54 offensive plays, amassing a total of 548 yards, and showed strength in their ground game, rushing 37 times for 355 yards, averaging a remarkable 9.6 yards per carry.

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Throughout the season, the Indiana Hoosiers have accumulated a total of 5,806 offensive yards. In terms of scoring, they have achieved 37 touchdowns through the air and 29 on the ground while turning the ball over just 7 times. The Hoosiers have successfully recorded 304 first downs and committed 44 penalties for a total of 322 yards. Their rushing attack ranks 9th nationally, averaging 229.8 yards per game, and they put up an impressive 44.3 points per game on the scoreboard.

Defensively, Indiana ranks 2nd in the nation in points allowed, giving up only 10.9 points per game. Opponents average just 2.9 rushing yards per carry and 79.3 rushing yards per game against them, totaling only 952 yards allowed over 12 games. In the passing game, the Hoosiers have conceded 2,070 yards, placing them 14th in Division 1, yielding an average of 172.5 passing yards per contest and a completion percentage of 60.8%. Overall, they allow an average of 251.8 yards per game, securing a 4th-place position in college football, while giving up 6 passing touchdowns and 5 rushing touchdowns this season.

The Buckeyes also enter the game with a flawless 12-0 record. In their previous matchup, they triumphed over the Michigan Wolverines with a scoreline of 27-9. Ohio State recorded a total of 419 yards during the game on 73 plays, averaging 5.7 yards per play. In the rushing game, they achieved 186 yards on 47 attempts, averaging 4.0 yards per carry, while limiting their opponents to 100 rushing yards on 24 attempts (4.2 yards per rush). In the air, Ohio State’s defense allowed a completion percentage of 44.4%, yielding just 63 passing yards on 8 of 18 attempts.

In terms of offensive production, the Buckeyes rank 13th nationally, averaging 37.0 points per game. They also average 438.5 total yards per game, placing them 24th in the NCAA. Ohio State has accumulated 509 penalty yards through 54 infractions, ranking them 122nd nationally for aiding their opponents. They have thrown 5 interceptions and lost 4 fumbles, while recording 282 first downs throughout the season. The Buckeyes have amassed 3,204 passing yards, averaging 267.0 yards per game, which is 26th in Division 1, along with an average of 171.5 rushing yards per game for a total of 2,058 rushing yards this season.

Defensively, Ohio State has allowed 980 rushing yards (81.7 yards per game) and 4 rushing touchdowns this season. In the passing game, they have conceded 5 touchdowns and allowed an average of 121.3 passing yards per game, which currently ranks them 1st in the country. Overall, their defense has surrendered only 94 total points. They have recorded 6 fumble recoveries and 7 interceptions throughout the season. With 647 defensive plays, Ohio State’s defensive unit ranks 1st in college football, allowing just 7.8 points per game, placing them at the top of Division 1.

Which team will prevail in this pivotal Hoosiers/Buckeyes college football contest against the spread?

Predicted Outcome: Back the Buckeyes -4.0

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Pick: Ohio State Buckeyes -4.0
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