Indiana Hoosiers vs Oregon Ducks Prediction for 10/11/2025 College Football Picks, Best Bets & Odds

Home » Indiana Hoosiers vs Oregon Ducks Prediction for 10/11/2025 College Football Picks, Best Bets & Odds
  • Matchup: Indiana Hoosiers vs Oregon Ducks
  • Date: Saturday, October 11, 2025
  • Venue: Autzen Stadium, Eugene, OR
  • Broadcast: CBS
  • Betting Line: Ducks favored by 7.5 points
  • Over/Under Total: 54.5

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The Oregon Ducks (5-0) host the Indiana Hoosiers (5-0) at Autzen Stadium on Saturday, October 11, 2025. Indiana enters this game as 7.5-point underdogs, with an over/under set at 54.5 total points.

Currently undefeated at 5-0, the Indiana Hoosiers recently secured a victory against the Iowa Hawkeyes, finishing with a score of 20-15. They executed 62 plays, amassing 337 total yards. On the ground, the Hoosiers rushed 39 times for 104 yards, averaging 2.7 yards per carry. Defensively, Indiana allowed 92 rushing yards on 31 carries, averaging 3.0 yards per rush. The Hoosiers’ passing defense permitted 24 completions on 38 attempts, yielding a total of 192 passing yards and a completion rate of 63.2%.

College Football Predictions for Indiana Hoosiers vs Oregon Ducks

On the season, Indiana has accumulated 2,691 total yards. In terms of scoring, they have achieved 19 passing touchdowns and 11 rushing touchdowns, with only 2 turnovers. The Hoosiers have achieved 140 first downs overall, although they’ve faced 19 penalties costing them 150 yards. Their ground game is notable, averaging 267.8 rushing yards per game, placing them 5th in Division 1. Indiana’s scoring average is impressive, standing at 47.8 points per game.

Defensively, Indiana ranks 3rd nationally for opponent scoring, allowing just 9.6 PPG. They have restricted opponents to an average of 3.2 yards per rush and 88.0 rushing yards per game this season with a total of 440 rushing yards conceded over five games. In the passing game, the Hoosiers have given up 667 yards, ranking them 7th, averaging 133.4 passing yards allowed per game and a completion rate of 59.5%. Overall, they’re allowing an average of 221.4 yards per game, which also places them 5th in the country, conceding just 1 passing and 3 rushing touchdowns.

The Ducks, also with a perfect record of 5-0, triumphed in their latest outing against the Penn State Nittany Lions, finishing with a 30-24 victory. Oregon recorded 424 total yards across 78 plays, averaging 5.4 yards per play. In the rushing department, Oregon averaged 4.5 yards per carry, finishing the game with 176 rushing yards on 39 attempts. Defensively, the Ducks permitted 139 rushing yards on 35 carries, averaging 4.0 yards per run, while their passing defense allowed a completion rate of 56.0% with 137 yards on 14 of 25 attempts.

In terms of scoring, the Ducks rank 6th in college football with an average of 46.6 PPG. They also boast an impressive 503.8 yards per game, placing them 9th nationally. Oregon’s offense has incurred 138 penalty yards from 18 infractions, ranking 131st in the country in terms of discipline. They have thrown 1 interception and have yet to lose a fumble, charting 123 first downs this season. Their passing offense has accumulated 1,322 yards, averaging 264.4 yards per game, making them 40th nationally, while also achieving an average of 239.4 rushing yards per game for a total of 1,197 rushing yards for the season.

Defensively, Oregon has allowed 574 rushing yards (114.8 yards per game) and 5 rushing touchdowns. They have conceded 2 passing touchdowns along with 123.4 yards per game through the air, which ranks them 3rd nationally. This season, they have allowed 61 points in total. Oregon has registered 1 fumble recovery and 5 interceptions to date, with their defense on the field for 286 plays, ranking them 11th in the country. They hold a formidable average of 12.2 PPG against, placing them 6th in college football.

Who will cover the spread in the Hoosiers vs. Ducks matchup?

Predicted Outcome: Ducks to cover -7.5

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Pick: Oregon Ducks -7.5
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