- Matchup: Iowa State Cyclones vs Colorado Buffaloes
- Date: Saturday, October 11, 2025
- Venue: Folsom Field, Boulder, CO
- Broadcast: ESPN
- Betting Odds: Buffaloes (+4.0)
- Total Points Over-Under: 53
This page may include affiliate links at no extra cost to you, thanks for your support.
On Saturday, October 11, 2025, Folsom Field will host the exciting clash between the Colorado Buffaloes (2-4) and the Iowa State Cyclones (5-1). Iowa State enters this game as 4-point favorites according to the latest Las Vegas odds, with the overall game total set at 53 points.
This season, the Iowa State Cyclones hold a commendable 5-1 record. In their previous game against the Cincinnati Bearcats, they faced a setback, losing 38-30. Throughout that match, Iowa State executed 85 plays, gaining 470 yards in total. The Cyclones managed to run the ball on 37 occasions, amassing 156 rushing yards at an average of 4.2 yards per carry. Defensively, they struggled against the run, allowing 260 yards on 34 carries, averaging 7.6 yards per run. The passing defense permitted 13 completions on 25 attempts for a total of 214 passing yards, resulting in a completion percentage of 52.0%.
This year, the Cyclones have accumulated 2,396 total offensive yards. In terms of scoring, Iowa State has recorded 9 touchdown passes and 14 rushing touchdowns, with 5 turnovers on the season. Offensively, they boast 129 first downs while incurring 21 penalties totaling 173 yards. Iowa State averages 151.0 rushing yards per game, placing them 79th nationally, and scores an average of 31.3 points per game.
On defense, the Cyclones rank 31st in NCAA Division I, yielding only 18.2 points per game. Opponents are gaining an average of 4.6 yards per rush and 141.8 rushing yards per game. So far this season, Iowa State has given up 851 rushing yards over 6 games. In terms of passing, they have conceded 1,171 yards, ranking 72nd in the nation, and allow an average of 195.2 passing yards per game with a 59.7% completion rate. Overall, they give up around 337.0 yards per game, placing them 54th in NCAA Division I and allowing 7 touchdowns through the air along with 6 on the ground.
The Colorado Buffaloes enter this matchup with a record of 2-4 for the current season. In their last game against the TCU Horned Frogs, they suffered a defeat, ending 35-21. Colorado’s rushing defense limited opponents to 94 yards on 35 attempts (2.7 yards/rush). The passing defense allowed a completion rate of 69.7%, surrendering 275 yards with 23 completions out of 33 attempts. The Buffaloes gained 343 total yards, averaging 5.3 yards per play, with a rushing average of 3.6 yards per attempt, totaling 126 rushing yards on 35 carries.
When it comes to scoring, Colorado ranks 89th in Division I, averaging 25.0 points per game. Their offensive yardage averages 355.7 yards per game, placing them 92nd nationally. This season, the offensive unit has received 293 yards in penalties over 32 infractions, ranking 74th in Division I in terms of mistakes made. They’ve thrown 6 interceptions and allowed 2 fumbles to be recovered by opponents, while achieving 115 first downs. Collectively, the Buffaloes have amassed 1,271 passing yards, averaging 211.8 passing yards per game, landing them at 85th in the nation while averaging 143.8 rushing yards per game with 863 rushing yards overall.
Defensively, Colorado has surrendered 1,080 rushing yards (180.0 yards/game) and 8 rushing touchdowns this season. They have also conceded 9 passing touchdowns, allowing 218.8 passing yards per game, ranking them 70th nationally. Overall, they have given up 149 points. This year’s defense registered 3 fumbles and 2 interceptions, participating in 411 defensive plays, which ranks 126th in Division I. The Buffaloes allow 24.8 points per game, positioning them at 75th in the nation.
Who will emerge victorious in this college football showdown between the Cyclones and Buffaloes against the spread?
Prediction: Back the Cyclones -4.0
Some links on this page are affiliate links. If you sign up or make a purchase through them, we may earn a small commission always at no extra cost to you. Thanks for helping us keep this site running.
