Kansas Jayhawks vs Iowa State Cyclones Prediction for 11/22/2025 College Football, Top Picks & Odds

Home » Kansas Jayhawks vs Iowa State Cyclones Prediction for 11/22/2025 College Football, Top Picks & Odds

  • Game: Kansas Jayhawks vs Iowa State Cyclones
  • Date: Saturday, November 22, 2025
  • Location: Jack Trice Stadium, Ames, IA
  • Broadcast: FS1
  • Betting Odds: Cyclones favored by 4.5 points
  • Over-Under Total: 55

This page may include affiliate links at no extra cost to you, thanks for your support.

This upcoming clash features the Iowa State Cyclones (6-4) welcoming the Kansas Jayhawks (5-5) to Jack Trice Stadium on Saturday, November 22, 2025. The Cyclones are positioned as 4.5-point favorites, with an over/under set at 55.

The Kansas Jayhawks enter this game with a balanced record of 5-5 this season. Their latest outing resulted in a narrow 24-20 defeat against the Arizona Wildcats. Across that match, Kansas executed 70 plays, accumulating a total of 369 yards. The rushing attack netted 170 yards on 40 carries, translating to an average of 4.3 yards per attempt. Defensively, the Jayhawks allowed 165 yards on 29 carries, averaging 5.7 yards per rush. Additionally, Kansas permitted the Wildcats to complete 16 passes out of 31 attempts for 158 yards, yielding a completion percentage of 51.6%.

College Football Picks: Predictions for Kansas Jayhawks

This season, the Jayhawks have accrued a total of 3,886 yards. They have scored 21 touchdowns through the air and 14 on the ground, but have also turned the ball over 9 times. Kansas has achieved 205 first downs while incurring 52 penalties totaling 420 yards. On average, they generate 159.7 rushing yards per game, placing them 67th in the nation. They average 30.2 points scored per game.

In terms of defensive statistics, the Jayhawks have given up 2,075 passing yards, ranking them 48th nationally. They allow 207.5 yards per game through the air, coupled with a completion percentage of 63.2%. Overall, their defense yields 377.0 total yards per game, placing the team 79th in total defense. Kansas has surrendered 13 touchdown passes and 17 rushing touchdowns, giving up an average of 4.7 yards per rush and 169.5 rushing yards per game. Over 10 games, this adds up to 1,695 rushing yards allowed, ranking them 74th in allowing points with 25.2 per game.

The Iowa State Cyclones, standing at 6-4, are coming off a thrilling victory, edging past the TCU Horned Frogs 20-17 in their last game. They managed to compile 272 total yards from 65 plays, averaging 4.2 yards per play. Iowa State’s rushing game recorded 161 yards on 41 attempts with an average of 3.9 yards per carry. On defense, the Cyclones faced 30 run attempts that resulted in 113 yards allowed (3.8 yards per rush). The pass defense allowed a completion rate of 68.0%, giving up 319 yards on 34 of 50 passing.

Regarding scoring, the Cyclones average 27.1 points per game, ranking them 70th in Division 1. Their offense totals 394.5 yards per game, placing 64th nationally. Iowa State has committed 396 yards in penalties across 47 infractions, positioning them at 116th in terms of giving away advantages to opponents. They have thrown 9 interceptions and relinquished 4 fumbles, while securing 211 first downs. Throughout the season, the Cyclones have amassed 2,303 passing yards and average 230.3 passing yards per game, which ranks them 68th nationally. Their rushing attack averages 164.2 yards per game, totaling 1,642 rushing yards so far.

Iowa State allows an average of 21.5 points per game, ranking them 40th in college football. They have surrendered a total of 1,497 rushing yards (149.7 yards per game) and 12 rushing touchdowns. Opponents have scored 13 passing touchdowns against them, along with 222.9 passing yards per game, ranking 73rd nationally. The Cyclones’ defense has been tested with 653 plays, placing them 47th in college football. They have recovered 6 fumbles and intercepted 9 passes this season, totaling a conceding of 215 points.

Which team will prevail in tonight’s contest between the Jayhawks and Cyclones?

Pick: Opt for the Cyclones -4.5

Some links on this page are affiliate links. If you sign up or make a purchase through them, we may earn a small commission always at no extra cost to you. Thanks for helping us keep this site running.

Pick: Iowa State Cyclones -4.5
Bet Now

Leave a Reply

Your email address will not be published. Required fields are marked *

New Bookmakers
Bet99

Proud Partner of the NHL + Excellent live betting

 

Betway

Widest Range of Betting Options + Robust in-play with streaming

BetMGM

Top-Rated Betting App in Ontario with Live streaming & Cash-out

Sports Interaction

Crafted for Canada’s Bettors. Best Odds For NHL, CFL & NFL

© 2025 BettingEdge.ca. All Rights Reserved. BettingEdge.ca is your trusted source for Canadian sportsbook reviews, betting tips, and responsible gaming resources. Must be 19+ to bet. Play responsibly.