Las Vegas Raiders at Indianapolis Colts Prediction, 10/5/2025 NFL Picks, Best Bets & Odds Week 5

Home » Las Vegas Raiders at Indianapolis Colts Prediction, 10/5/2025 NFL Picks, Best Bets & Odds Week 5

  • Matchup: Las Vegas Raiders vs Indianapolis Colts
  • Event Date: Sunday, October 5, 2025
  • Venue: Lucas Oil Stadium, Indianapolis, IN
  • Broadcast: FOX
  • Betting Odds: Colts (-7)
  • Total Points: 48

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The Indianapolis Colts (3-1) will host the Las Vegas Raiders (1-3) at Lucas Oil Stadium this Sunday. Indianapolis enters this game as 7-point favorites. The over-under for the match is set at 48 points.

The Las Vegas Raiders are facing a tough season with a current record of 1-3. In their previous game, they suffered a narrow defeat against the Chicago Bears, finishing 25-24. Quarterback Geno Smith completed 14 of 21 passes for 117 yards and 2 touchdowns but struggled with 3 interceptions, resulting in a QB rating of 73. Brock Bowers averaged 9.2 yards per reception, accumulating 46 yards on 5 catches. Ashton Jeanty led the rushing attack, carrying the ball 21 times for 138 yards, averaging 6.6 yards per carry. The Raiders managed 52 plays for a total of 357 yards. They rushed 31 times, compiling 240 yards at an impressive average of 7.7 yards per carry. Defensively, the Raiders allowed 69 yards on 26 rushing attempts, yielding an average of 2.7 yards per carry. In the passing game, they conceded 22 completions on 37 attempts for a total of 202 yards, with a completion rate of 59.5%.

NFL predictions for Colts game

Regarding offensive scoring, the Raiders are averaging 19.3 points per game. They gain approximately 114.3 rushing yards, ranking 15th in the NFL. This season, Las Vegas has accumulated a total of 1,318 yards, achieved 43 first downs, and committed 25 penalties costing them 214 yards. They have turned the ball over 8 times (7 interceptions and 1 fumble) and scored 6 touchdowns through the air alongside 2 rushing touchdowns.

Defensively, the Raiders are positioned 22nd in the league, giving up an average of 24.8 points per game. Opponents rush for an average of 4.0 yards per carry, totaling 102.8 rushing yards per game against them. In terms of passing, Las Vegas has allowed 913 yards this season, ranking them 23rd in the NFL, with an average of 228.3 passing yards per game and a completion rate of 65.6%. Overall, they surrender 331.0 total yards per contest, which places them 21st in the league. They have allowed 5 passing touchdowns and 4 rushing touchdowns, with 411 rushing yards given up across four games this season.

The Colts enter this contest with a record of 3-1. In their last outing, they were edged by the Los Angeles Rams, with the final score being 27-20. Quarterback Daniel Jones threw for 262 yards on 24 of 33 passing, including 1 touchdown but also had 2 interceptions, finishing with a QB rating of 80.6 and averaging 7.9 yards per attempt. Jonathan Taylor rushed 17 times for 76 yards, averaging 4.5 yards per carry. Michael Pittman Jr. was a key receiver, catching 5 passes for 41 yards (8.2 yards per reception). The Colts rushed for a total of 85 yards on 21 attempts at an average of 4.0 yards per carry. Overall, Indianapolis gained 333 total yards over 54 plays, averaging 6.2 yards per play. Their pass defense allowed a completion percentage of 70.7%, giving up 360 yards on 29 of 41 passing attempts. They conceded 102 rushing yards on 26 carries (3.9 yards per carry).

The Indianapolis Colts are averaging 397.3 total yards per game, ranking them 3rd in the NFL. They average 136.3 rushing yards per contest, totaling 545 rushing yards for the season. The offense has recorded 51 first downs, experienced 2 interceptions, and has fumbled the ball once. In terms of penalties, they have accumulated 224 total yards from 30 infractions, placing 14th regarding self-inflicted wounds. The Colts have passed for a total of 1,044 yards this season, averaging 261.0 passing yards, good enough for 4th in the league. In scoring, they are 4th in the NFL with an average of 30.8 points per game.

Defensively, they have given up 8 passing touchdowns and allow 223.8 passing yards per game, ranking 21st in the league. The Colts have conceded 384 rushing yards (96.0 yards per game) along with 2 rushing touchdowns this season. Their defense has created 6 turnovers (2 forced fumbles and 4 interceptions) throughout the season and has allowed a total of 83 points. The Colts’ defense has been involved in 235 plays, placing them 10th in the NFL. They are allowing an average of 20.8 points per game, positioning them 12th in the league.

Will the Raiders cover the spread against the Colts in today’s NFL showdown?

Prediction: Take the Raiders +7

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Pick: Las Vegas Raiders +7
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