Los Angeles Angels and Colorado Rockies Prediction for 9/21/2025 MLB Picks, Best Bets & Odds

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• Matchup: Los Angeles Angels vs Colorado Rockies
• Event Date: Sunday, September 21, 2025
• Venue: Coors Field, Denver, CO
• Broadcast: Rockies.TV
• Betting Odds: Los Angeles (-122) Colorado (+102)

The Colorado Rockies (41-112) are set to face the Los Angeles Angels (69-84) at Coors Field this Sunday. The current betting line has the Angels at -122 and the Rockies at +102, with a game total of 8.5 runs. Pitching duties will be handled by Kyle Hendricks and German Marquez.

As of now, the Los Angeles Angels are averaging 4.2 runs per game, placing them 25th in the league. They have scored a total of 645 runs with an on-base percentage (OBP) of .300. The Angels have recorded 204 doubles and 212 home runs, totaling 623 RBIs and 1,151 hits this season, with a batting average of .226. Their slugging percentage is .398, with 1,540 strikeouts and 463 walks taken.

The Angels currently hold a team earned run average (ERA) of 4.89, ranking 28th in the league, having struck out 1,203 batters. They’ve allowed 211 home runs and have given up 793 runs (28th in the league). Their pitching staff has issued 595 walks, with a FIP of 4.82 for the season. Los Angeles has surrendered 1,358 hits (9.0 per 9 innings) and 735 earned runs, resulting in a strikeout-to-walk ratio of 2.02 and a collective WHIP of 1.44.

The Angels’ bullpen has a save percentage of 50.7%, entering 150 save opportunities. Relief pitchers have inherited 209 runners this season, with 37.8% scoring. The Angels’ relievers have been called upon in high-pressure situations 201 times, and so far this year, they have recorded 78 holds (21st in MLB). With 35 saves this season, they have blown 34 of 69 save opportunities.

Defensively, the Angels have converted 68.8% of balls put in play into outs over their 12,099 innings, ranking 25th in MLB. Moreover, they have recorded 4,033 putouts, 1,321 assists, and 91 errors, boasting a fielding percentage of .983, which puts them at 26th in the league. They have executed 152 double plays this season.

Kyle Hendricks (career record of 104-91) has a FIP of 3.75, having faced 7,167 batters in the majors. He has allowed 1,660 hits (8.6 hits per nine innings) and issued 407 walks, with an ERA of 3.80 (732 ERs allowed) and a WHIP of 1.193. Hendricks has pitched 1,732 innings and accumulated 1,360 strikeouts throughout his professional career.

The Colorado Rockies, on the other hand, hold a team slugging percentage of .390 while averaging just 3.75 runs per game (29th in the league). They have successfully hit 243 doubles, while drawing 376 walks and scoring 574 runs. Their record includes 154 home runs, leading to 559 RBIs. With 1,439 strikeouts this season (2nd in MLB), the Rockies have amassed 1,227 hits, a .296 OBP, and a .239 batting average.

The Rockies’ pitching staff has given up 978 runs this year, posting a team ERA of 6.04 (894 earned runs). They have surrendered 234 home runs and allow 6.61 runs per 9 innings (30th in MLB). As a unit, their WHIP is 1.599 with a FIP of 5.23 for the season. Their strikeout-to-walk ratio stands at 6.90 (1,015 strikeouts against 525 walks), ranking them at the bottom of the league for total hits allowed with 1,605.

Out of 104 save situations, the Rockies have recorded 53 holds but have also blown 24 saves. Their relievers have been utilized in 51 save opportunities, achieving 27 saves. Colorado’s bullpen pitchers have entered games 131 times in high leverage situations and faced runners in scoring positions on 156 occasions. Currently, they hold a 34.8% inherited score percentage from 267 inherited runners and sit at 27th in the league with a save percentage of 52.9%, having used 503 relievers this season.

The Colorado Rockies have executed 146 double plays, posting a fielding percentage of .981 (29th in MLB). They have made 1,391 assists, committed 106 errors, and accumulated 3,970 putouts this year. Over their 11,910 innings played, their defensive efficiency percentage is 65.8%, ranking them last in MLB.

Throughout his career, German Marquez has allowed 1,165 hits and accumulated 1,063 strikeouts over 1,135 innings pitched. He has surrendered 586 earned runs, with a WHIP of 1.335 and a FIP of 4.6. His strikeout-to-walk ratio is at 3.04, having faced 4,859 batters during his professional tenure. Marquez holds a career win-loss record of 68-70 with a 4.65 ERA, allowing 9.2 hits per nine innings.

Who do you think will emerge victorious in tonight’s MLB game—against the spread or on the moneyline?

Recommendation: Bet on Los Angeles (-122)