- Matchup: Louisville Cardinals vs SMU Mustangs
- Date: Saturday, November 22, 2025
- Venue: Gerald J. Ford Stadium, Dallas, TX
- Broadcast: ESPN2
- Point Spread: Mustangs favored by 3.0 points
- Total Points Over/Under: 52.5
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The SMU Mustangs (7-3) aim to challenge the Louisville Cardinals (7-3) at Gerald J. Ford Stadium on Saturday, November 22, 2025. SMU enters this contest as 3.0-point favorites according to Las Vegas odds. The total points are projected at 52.5.
The Louisville Cardinals come into this game with a record of 7-3. Their most recent outing saw them face off against the Clemson Tigers, resulting in a narrow defeat with a score of 20-19. In that match, the Cardinals executed 30 rushing attempts for a total of 171 yards, averaging 5.7 yards per carry. Over the course of 59 offensive plays, they amassed 385 total yards. Defensively, Louisville allowed 31 completions on 49 attempts, resulting in 350 passing yards and a completion percentage of 63.3%. On the ground, they surrendered 77 yards from 25 rushing attempts, averaging 3.1 yards per carry allowed.
On the season, the Cardinals have accumulated 3,998 total yards. They have recorded 13 touchdown passes along with 21 rushing touchdowns, but have also turned the ball over 15 times. Offensively, they have achieved 197 first downs and have been penalized 69 times for a total of 652 yards. The Cardinals average 156.5 rushing yards per game, placing them 71st in NCAA Division I football. When it comes to scoring, they are averaging 31.5 points per game.
Defensively, Louisville ranks 39th in the nation, giving up an average of 21.5 points per game. Opponents have rushed for an average of 3.4 yards per carry, totaling 109.9 rushing yards per game throughout the season. In 10 games, Louisville has allowed 1,099 rushing yards. In terms of passing defense, the Cardinals have allowed 1,880 passing yards, ranking them 26th in college football, permitting an average of 188.0 yards per game along with a 57.4% completion rate. Overall, their defense has yielded an average of 297.9 yards per game, ranking them 16th in Division I.
The Mustangs enter this matchup with a record of 7-3. Their latest game resulted in a commanding victory against the Boston College Eagles, where they won 45-13. SMU’s defense faced 40 rushing attempts, allowing 98 yards (averaging 2.5 yards per carry). Through the air, their pass defense recorded a completion percentage of 64.4%, allowing 284 yards on 29 completions from 45 attempts. SMU registered a total of 574 yards for the game, running 66 plays at an impressive 8.7 yards per play. They averaged 7.2 yards per carry, totaling 222 rushing yards on 31 attempts.
The SMU Mustangs produce an average of 406.6 yards per game, placing them 54th nationally. Their offense has committed 69 penalties, resulting in 712 penalty yards, ranking them 37th in aiding the opposition. They average 122.1 rushing yards per game, totaling 1,221 yards this season. They have thrown 9 interceptions, allowed 6 fumbles to be recovered by opponents, and achieved 200 first downs. In scoring, the Mustangs are currently ranked 40th in Division I, averaging 32.2 points per game. Throughout the season, the Mustangs have passed for 2,845 yards, averaging 284.5 passing yards per game, placing them 18th in the nation.
Defensively, SMU has allowed 1,021 rushing yards this season (102.1 yards per game) along with 4 rushing touchdowns. The passing defense has given up 19 touchdowns and an average of 298.6 yards per game, ranking 135th in Division I. In total, they have conceded 204 points. Their defense has recovered 10 fumbles and intercepted 16 passes this season. With 773 plays faced, the Mustangs defense ranks 134th in the country. They are allowing 20.4 points per game, positioning them 31st in college football.
Which team will prevail in tonight’s Cardinals vs. Mustangs college football showdown?
Prediction: Bet on the Mustangs -3.0
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