Michigan State Spartans vs Indiana Hoosiers Prediction and Betting Odds for College Football on 10/18/2025

Home » Michigan State Spartans vs Indiana Hoosiers Prediction and Betting Odds for College Football on 10/18/2025

  • Matchup: Michigan State Spartans vs. Indiana Hoosiers
  • Scheduled Date: Saturday, October 18, 2025
  • Venue: Memorial Stadium, Bloomington, IN
  • Broadcast: Peacock
  • Betting Odds: Hoosiers favored by 27.5 points
  • Over/Under: 53 points

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The Michigan State Spartans (3-3) are set to face off against the Indiana Hoosiers (6-0) this coming Saturday at Memorial Stadium. Indiana enters the game as 27.5-point favorites, with the over/under line established at 53 points.

This season, the Michigan State Spartans carry a record of 3-3. In their latest outing, they were defeated by the UCLA Bruins, falling with a score of 38-13. The Spartans executed 25 rushing attempts, accumulating a total of 87 yards, averaging 3.5 yards per carry. Over the course of the game, they ran 60 plays resulting in 253 total yards. Defensively, Michigan State allowed 16 completions on 24 attempts, yielding 180 passing yards, with a completion rate of 66.7%. The Spartans faced several challenges against the run, conceding 238 yards over 43 attempts, averaging 5.5 yards per carry.

college football picks Aidan Chiles Michigan State Spartans predictions best bet odds

Throughout the season, the Spartans have recorded a total of 1,990 yards. In scoring, they have achieved 11 passing touchdowns alongside 12 rushing touchdowns, while also committing 8 turnovers. Offensively, Michigan State has achieved 115 first downs and incurred 26 penalties totaling 217 yards. They average 131.2 rushing yards per game, placing them 97th in Division 1. In terms of points, the Spartans score an average of 29.5 points per game.

Defensively, the Spartans rank 121st in college football, allowing 31.8 points per game. They concede an average of 4.2 yards per carry and 131.2 rushing yards per game this season, totaling 787 rushing yards allowed over 6 games. In terms of passing defense, they have allowed 1,428 yards, placing them 92nd in the nation, yielding 238.0 passing yards per game with a completion rate of 67.3%. Overall, Michigan State has averaged 369.2 yards allowed per game, ranking 71st nationally, giving up 13 passing touchdowns and 10 rushing touchdowns.

The Indiana Hoosiers enter this contest with a perfect record of 6-0. In their most recent game, they secured a 30-20 victory over the Oregon Ducks. The Hoosiers finished with 326 total yards after running 68 plays, averaging 4.8 yards per play. Indiana’s rushing attack averaged 3.0 yards per carry, totaling 111 yards on 37 attempts. Defensively, they limited their opponents to 81 rushing yards on 30 attempts, averaging 2.7 yards per carry, while the pass defense yielded a completion rate of 61.8%, allowing 186 yards on 21 completions from 34 attempts.

On offense, the Indiana Hoosiers average 502.8 yards per game, ranking them 8th nationally. They have accumulated 195 penalty yards from 27 infractions, placing them 118th in the nation for self-inflicted setbacks. They average 241.7 rushing yards per game, totaling 1,450 rushing yards for the season, alongside 2 interceptions and 1 lost fumble, while achieving 163 first downs. In scoring, Indiana is 4th nationally, averaging 44.8 points per game. This season, they have amassed 1,567 passing yards, averaging 261.2 passing yards per game, ranking them 42nd overall.

Defensively, the Hoosiers have allowed 521 rushing yards (86.8 yards per game) and 3 rushing touchdowns this season. They have also given up 2 passing touchdowns and 142.2 passing yards per game, placing them 6th in Division 1. The total points allowed by the Hoosiers is 68. Their defensive unit has forced 1 fumble recovery and 9 interceptions so far this season, participating in 327 defensive plays, which is 4th in Division 1. The Indiana defense is allowing just 11.3 points per game, putting them at 4th in the nation.

Who will emerge victorious in this electrifying Spartans vs. Hoosiers college football matchup?

Expert’s Pick: Betting on the Spartans +27.5

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Pick: Michigan State Spartans +27.5
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