Milwaukee Brewers vs Pittsburgh Pirates Prediction for 9/5/2025 MLB Picks, Best Bets & Odds

Game: Milwaukee Brewers vs Pittsburgh Pirates

Date: Friday, September 5, 2025

Location: PNC Park in Pittsburgh, PA

Broadcast: SportsNet Pittsburgh

Odds/Point Spread: Milwaukee (-275) Pittsburgh (+220)

PNC Park will host the matchup where the Pittsburgh Pirates (63-77) face off against the Milwaukee Brewers (86-54) this Friday. The moneyline for this game sees the Brewers favored at -275, while the Pirates are positioned at +220. The total runs over/under is set at 9, with Quinn Priester and Johan Oviedo as the starting pitchers.

This season, the Brewers have recorded 227 doubles and hit 152 home runs, boasting a slugging percentage of .409. They have struck out 1,095 times while drawing 484 walks. As a unit, the Milwaukee Brewers average 5.1 runs per game, ranking them 2nd in the league. They have amassed 667 RBIs and 1,233 hits, with a batting average of .259. Moreover, they have scored 717 runs collectively and maintain an on-base percentage of .333.

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The Brewers hold a team earned run average (ERA) of 3.65 (ranking 2nd in the league), with their pitching staff striking out 1,221 batters. This season, Brewers pitchers have conceded 148 home runs and a total of 553 runs (4th in MLB). Their pitching crew has issued 462 walks, with a team FIP of 3.97. Milwaukee has allowed 1,083 hits (averaging 7.8 per 9 innings) and 505 earned runs. They possess a K/BB ratio of 2.64, and their overall WHIP is 1.24.

The Brewers’ bullpen has entered games with players on base 125 times and participated in 164 critical situations. They have amassed 97 holds so far (ranking 2nd in the league). With a save percentage of 67.8%, the bullpen has been called upon 160 times for save opportunities, successfully converting 40 of them, while blowing 19 saves. Additionally, they have inherited 187 runners this season, with 30.5% of those scoring. Overall, the Brewers have utilized 475 relief pitchers throughout the season.

In the field, the Brewers have converted 70.8% of balls in play into outs across 11,220 innings, making them 6th in the majors. The Miami Marlins have recorded 3,740 putouts, 1,119 assists, and 64 errors this season, holding a fielding percentage of .987, ranking them 10th in the league, alongside 104 double plays turned.

Quinn Priester has pitched 233 innings in his career, collecting 176 strikeouts. With a career record of 17-11, he has a FIP of 4.48, facing 1,013 batters with an ERA of 4.55 (allowing 118 earned runs) and a WHIP of 1.380. He has given up 236 hits (9.1 hits per nine innings) and issued 86 walks.

The Pirates currently demonstrate a slugging percentage of .353, scoring an average of 3.66 runs per game (30th in MLB). They’ve recorded 210 doubles, walked 460 times, and accumulated 512 runs this season. Pittsburgh has also connected for 102 home runs and has tallied 492 RBIs. The team has struck out 1,216 times (ranking 9th in the league), notched 1,086 hits, and holds an on-base percentage of .308 along with a team batting average of .234 this season.

On the mound, the Pirates have allowed 569 runs, maintaining a team ERA of 3.88 (with 532 earned runs yielded). They’ve surrendered 134 home runs and allow an average of 4.15 runs per 9 innings (7th in the league). Their WHIP stands at 1.218, while they possess a fielding independent pitching (FIP) of 3.90 as a team. They have achieved a K/BB rate of 8.00 (1,104 strikeouts against 404 walks), ranking 7th overall for hits allowed with a total of 1,099.

The Pirates’ bullpen records an inherited run score percentage of 36.9% from their 187 inherited runners. They have faced 133 high-leverage situations and 120 appearances with runners on base. In save scenarios, they’ve achieved 64 holds and 21 blown saves, resulting in a save percentage of 60.4%, placing them 23rd in the league for the year. The bullpen has utilized 434 pitchers in total this season, declaring 32 saves from 53 save chances.