Milwaukee Brewers vs San Diego Padres Prediction for 9/22/2025 MLB Picks, Top Bets & Odds

Home » Milwaukee Brewers vs San Diego Padres Prediction for 9/22/2025 MLB Picks, Top Bets & Odds
  • Matchup: Milwaukee Brewers vs. San Diego Padres
  • Date: Monday, September 22, 2025
  • Venue: Petco Park, San Diego, CA
  • Broadcast: Padres.TV
  • Betting Odds: Milwaukee (-152) San Diego (+126)

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The Milwaukee Brewers (94-59) are heading to Petco Park on Monday, aiming to secure a win against the San Diego Padres (83-70). The moneyline for this contest positions Milwaukee at -152, while San Diego stands at +126. The total runs expected for the game are set at 8.5, with anticipated starting pitchers Freddy Peralta and Nick Pivetta taking the mound.

MLB Predictions for Milwaukee Brewers

This season, the Milwaukee Brewers have averaged 5.1 runs per game, placing them 2nd in the league. They have accumulated a total of 785 runs with an on-base percentage of .334. The team has successfully hit 251 doubles and sent 162 balls over the fence. With 729 RBIs and 1,357 hits, their overall batting average stands at .261. Milwaukee boasts a slugging percentage of .409 but has also recorded 1,187 strikeouts, drawing walks 533 times.

The Brewers currently showcase an earned run average of 3.60 (2nd in the league), with their pitching staff recording 1,361 strikeouts. They have given up 159 home runs and allowed a total of 595 runs (2nd in MLB). The team has issued 502 walks, and their FIP is 3.91. Milwaukee has relinquished 1,164 hits (averaging 7.7 hits per 9 innings) and has allowed 544 earned runs. Their strikeout-to-walk ratio stands at 2.71, with a WHIP of 1.22.

This season, Brewers relief pitchers have faced runners on base 134 times, contributing to 171 high-leverage situations. They have achieved 101 holds (5th in MLB) and possess a save percentage of 69.4%. With 167 save chances, they have made good on 43 saves while failing 19 times. Relievers have inherited 199 runners this year, with 30.2% of those scoring. The Brewers have utilized 516 relievers this season.

Defensively, the Brewers have converted 70.9% of balls in play into outs during their 12,255 innings, ranking 6th in the league. The Miami Marlins have recorded 4,085 putouts, along with 1,213 assists and 70 errors. Their fielding percentage is .987, putting them 10th in MLB, with 111 double plays turned.

Freddy Peralta has pitched 923 innings in his MLB career, earning 1,144 strikeouts with an ERA of 3.59 (368 earned runs). He maintains a WHIP of 1.133, having permitted 687 hits (averaging 6.7 hits per 9 innings) and issued 359 walks. With a career win-loss record of 70-42, his FIP is 3.53, having faced 3,824 hitters in the majors.

The San Diego Padres have hit 140 home runs this season, driving in 615 runs. They have tallied 244 doubles, drawn 484 walks, and scored 652 runs overall. The Padres currently have an on-base percentage of .321 and a batting average of .252. They hold a team slugging percentage of .389, averaging 4.26 runs per game (22nd in MLB). The team has struck out 1,085 times, ranking 28th in baseball, with a total of 1,288 hits.

As a pitching staff, the Padres boast a WHIP of 1.204 and a FIP of 4.04. They lead MLB in total hits allowed, with 1,135. Conceding 171 home runs, they average 3.97 runs allowed per 9 innings (3rd in the league). The Padres’ pitching unit has given up 596 runs this season, with a team ERA of 3.69 (554 earned runs).

In 166 save situations, the Padres have achieved 98 holds but also encountered 16 blown saves. They have faced 63 save opportunities, securing 47 saves. Their bullpen pitchers have stepped in during 199 high-leverage situations and 174 occasions with base runners. The San Diego relief corps has an inherited score percentage of 29.7% out of 246 inherited runners and ranks 1st in baseball with a save rate of 74.6%. They have rolled out 541 relief pitchers this season.

In their 12,159 innings played, the Padres have a defensive efficiency of 71.7% (2nd in MLB). They have successfully executed 107 double plays, maintaining a fielding percentage of .987 (12th in the majors) with 1,151 assists, 70 errors, and 4,053 putouts this season.

Throughout his MLB career, Nick Pivetta has allowed 1,103 hits, tallying 1,324 strikeouts over 1,205 innings pitched. He has conceded 599 earned runs, holding a WHIP of 1.265 and a FIP of 4.4. His K/BB ratio stands at 3.14, having faced 5,082 batters to date. Pivetta carries a career win-loss record of 69-76 and an ERA of 4.47, allowing 8.2 hits per nine innings.

Which team will emerge victorious in tonight’s MLB matchup—covering the spread or earning the moneyline?

Pick: Favor Milwaukee (-152)

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Pick: Milwaukee Brewers (-152)
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