Milwaukee Brewers vs St. Louis Cardinals Forecast, 9/21/2025 MLB Picks, Top Bets & Odds

This page may include affiliate links at no extra cost to you, thanks for your support.

• Matchup: Milwaukee Brewers vs. St. Louis Cardinals
• Date: Sunday, September 21, 2025
• Venue: Busch Stadium, St. Louis, MO
• Broadcast: FanDuel Sports Network Midwest
• Betting Odds: Milwaukee (-150) St. Louis (+125)

The St. Louis Cardinals (74-79) will face the Milwaukee Brewers (94-59) at Busch Stadium this Sunday. The betting line for this matchup has the Brewers favored at -150, while the Cardinals are positioned at +125. The total runs over/under is set at 9. Starting pitchers for the game are Chad Patrick and Miles Mikolas.

The Milwaukee Brewers have a slugging percentage of .409, with 1,187 strikeouts and 533 walks recorded. To date, they have amassed 729 RBIs with a total of 1,357 hits, maintaining a batting average of .261. As a collective, the Brewers have hit 251 doubles and 162 home runs. They have scored a total of 785 runs with an on-base percentage of .334. Averaging 5.1 runs per game, they rank 2nd in the league.

The Brewers exhibit a K/BB ratio of 2.71 and their pitching staff holds a WHIP of 1.22. They have allowed 159 home runs and 595 runs total this season (2nd in the league). So far, the Brewers’ pitching rotation has permitted 1,164 hits (7.7 per 9 innings) and 544 earned runs, maintaining an ERA of 3.60 (2nd in MLB) with 1,361 strikeouts. Additionally, the pitching unit has issued 502 walks, with a FIP of 3.91 for the season.

Throughout this year, the Brewers have employed 516 relief pitchers. Their bullpen has inherited 199 runners, with 30.2% scoring. They have recorded 43 saves but failed to convert 19 out of 62 save attempts, achieving a save success rate of 69.4% across 167 save opportunities. The relievers have also notched 101 holds (5th in MLB), entering games with runners on base 134 times and 171 high leverage situations.

The Miami Marlins are currently at 4,058 putouts, alongside 1,207 assists and 69 errors, delivering a fielding percentage of .987, ranking 10th in MLB, and completing 111 double plays. The Brewers have converted 71.0% of balls in play into outs, ranking them 4th overall in professional baseball over 12,174 innings.

Patrick has pitched 111 innings in his career, achieving 116 strikeouts with an ERA of 3.65 (45 earned runs) and a WHIP of 1.287. He has given up 106 hits (8.6 hits per 9 innings) and 37 walks, holding a career FIP of 3.59 and facing 469 batters in the major leagues.

The St. Louis Cardinals have a collective on-base percentage of .314, along with a team batting average of .244 this season. They have struck out 1,240 times (22nd in the league) and accumulated 1,255 hits. The Cardinals have recorded 142 home runs and 620 RBIs, with a team slugging percentage of .378 and averaging 4.27 runs per game (19th in MLB). They have secured 243 doubles while drawing 451 walks, amassing a total of 653 runs.

As a staff, the Cardinals have a WHIP of 1.320 and a FIP of 4.04 this season, sitting 25th in the league for total hits given up at 1,349. The pitching staff has allowed 711 runs, with a team ERA of 4.29 (645 earned runs allowed). Their K/BB ratio stands at 7.50, with 1,135 strikeouts against 438 walks. They have conceded 156 home runs, averaging 4.73 runs allowed per 9 innings (22nd in the league).

The Cardinals have had their relievers enter 62 save opportunities, achieving 40 saves to rank 13th in MLB with a save rate of 64.5%. So far, they have deployed 456 relievers this season. Their bullpen pitchers have appeared in 148 high leverage situations, and have entered 148 times with runners on base. The Cardinals’ relievers have inherited 206 runners, with a scoring rate of 33.0%. In 152 save chances, the Cardinals have achieved 86 holds and experienced 22 blown saves.

Over 12,186 innings in the field, the Cardinals have posted a defensive efficiency rating of 69.0% (22nd in the majors). The St. Louis Cardinals have executed 121 double plays with a fielding percentage of .987 (13th in pro baseball). This season, they have recorded 1,465 assists, 75 errors, and achieved 4,062 putouts.

Mikolas, holding a career record of 72-74, has an ERA of 4.23 while allowing 9.2 hits per 9 innings. His K/BB ratio is 3.65, having faced 5,174 hitters in his career. He has given up a total of 584 earned runs, with a WHIP of 1.215 and a FIP of 4.2. Throughout his MLB journey, Mikolas has surrendered 1,266 hits while tallying 888 strikeouts in 1,242 innings.

Who will clinch victory in tonight’s MLB match? Will it be against the spread or the moneyline?

Prediction: Back St. Louis (+125)