Minnesota Twins at Kansas City Royals Prediction for 9/6/2025 MLB Picks, Best Bets & Odds

Home » Minnesota Twins at Kansas City Royals Prediction for 9/6/2025 MLB Picks, Best Bets & Odds

Matchup: Minnesota Twins vs Kansas City Royals

Date: Saturday, September 6, 2025

Venue: Kauffman Stadium, Kansas City, MO

Broadcasting: FanDuel Sports Network Kansas City

Betting Odds: Minnesota (+172), Kansas City (-210)

This Saturday, the Minnesota Twins (62-77) will take on the Kansas City Royals (70-69) at Kauffman Stadium. The betting odds favor the Royals at -210, while the Twins enter with odds of +172. The total for the game is set at 8.5 runs. Starting pitchers for this matchup will be Pablo Lopez and Seth Lugo.

MLB Predictions for Minnesota Twins vs Royals

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This season, the Minnesota Twins are averaging 4.2 runs per game, ranking 25th in Major League Baseball. They have scored a total of 584 runs with a team on-base percentage of .311. With 213 doubles and 163 home runs, the Twins have recorded 555 runs batted in and 1,109 hits, resulting in a batting average of .238. Their slugging percentage stands at .397, although they have struck out 1,151 times and drawn 427 walks.

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The Twins have achieved a strikeout-to-walk ratio of 2.98, with a team WHIP of 1.32. The pitching staff has allowed 169 home runs and given up a total of 658 runs (23rd in the league). They have conceded 1,223 hits (9.0 hits per 9 innings) and 613 earned runs, resulting in a team ERA of 4.51 (24th in the league). The staff has accumulated 1,167 strikeouts while issuing 392 walks, leading to a FIP of 4.13 this season.

This season, Twins relief pitchers have faced 103 situations with runners on base and made 159 high-leverage appearances. They have achieved 84 holds, ranking 10th in MLB, with a save percentage of 54.2%. The Twins have completed 26 saves from 48 opportunities but have blown 22 chances. Overall, the relievers have inherited 148 base runners, with a 37.8% run scoring rate. This season, the Twins have used 472 different pitchers out of the bullpen.

In the field, the Minnesota Twins have accumulated 3,672 putouts, 1,034 assists, and 68 errors. They hold a fielding percentage of .986, placing them 16th in professional baseball, and have completed 85 double plays. With a defensive efficiency of 68.4%, they rank 27th in baseball.

Pablo Lopez has pitched 949 innings in his career, recording 982 strikeouts while maintaining a 3.84 ERA (405 earned runs) and a WHIP of 1.175. He has given up 870 hits (8.2 hits per nine innings) and issued 245 walks. Lopez holds a career record of 59-52 and a FIP of 3.78 against 3,930 batters.

The Kansas City Royals have achieved 132 home runs and 523 RBIs this year. They have recorded 244 doubles, earned 365 walks, and totaled 533 runs. Their on-base percentage stands at .306, while their team batting average is .245. The Royals slug .392 and average just 3.83 runs per game (28th in the league). They’ve struck out 945 times (30th in the league) and achieved 1,137 hits.

This season, the Royals’ pitching staff holds a team WHIP of 1.244 and a FIP of 3.97. They rank 10th in total hits allowed, giving up 1,128. The pitching staff has allowed 541 runs this year, with an impressive ERA of 3.66 (502 earned runs). The K/BB ratio is 7.90 (1,086 strikeouts vs. 409 walks) while giving up 142 home runs and 3.94 runs per nine innings (2nd in MLB).

The Royals’ bullpen has entered 59 save opportunities, converting 41, giving them a 69.5% save rate, good for 4th in MLB. They have used 466 relievers and faced high-leverage situations 151 times, including 139 times with runners on base. Their inherited score rate stands at 27.9% from 190 inherited runners. The Royals have tallied 73 holds alongside 18 blown saves in 133 save situations this season.

With 11,124 innings played, the Royals have a defensive efficiency of 70.8% (7th in MLB). They have executed 107 double plays and hold a fielding average of .989 (4th in professional baseball). This season, they have also recorded 1,228 assists, 56 errors, and 3,708 putouts.

Throughout his MLB career, Seth Lugo has allowed 889 hits while striking out 954 batters over 992 innings. He has permitted a total of 385 earned runs, posting a WHIP of 1.174 and a FIP of 3.4. With a K/BB ratio of 3.46, Lugo maintains a career record of 64-47 and an ERA of 3.49, allowing 8.1 hits per nine innings.

Who do you think will claim victory tonight in the MLB matchup against the spread or moneyline?

Suggestion from Tony Sink: Bet on Minnesota (+172)

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