- Matchup: Missouri Tigers vs Vanderbilt Commodores
- Date: Saturday, October 25, 2025
- Venue: FirstBank Stadium, Nashville, TN
- Broadcast: ESPN
- Betting Odds: Commodores favored by 2.5 points
- Over/Under Total: 52 points
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This exciting clash will unfold at FirstBank Stadium as the Vanderbilt Commodores (6-1) face off against the Missouri Tigers (6-1) on Saturday, October 25, 2025. The Commodores enter this matchup as 2.5-point favorites according to betting lines, with the total set at 52 points.
The Missouri Tigers arrive at this game boasting a strong 6-1 record this season. In their last outing, they secured a victory against the Auburn Tigers, winning 23-17. During that game, the Tigers executed 84 plays, accumulating 343 yards in total. Their rushing attack saw them carry the ball 44 times for 91 yards, averaging 2.1 yards per attempt. Defensively, the Tigers allowed 150 yards on 41 rushing attempts, which translates to 3.7 yards per carry. Additionally, they permitted 18 completions from 30 attempts, resulting in 207 passing yards and a completion percentage of 60.0%.

When it comes to scoring, the Missouri Tigers average 39.0 points per game, ranking them among the top scorers in the nation. They have amassed an impressive 244.9 rushing yards per contest, placing them 7th nationally. Overall, the Tigers have generated 3,406 total yards this season, including 12 touchdown passes and 22 rushing touchdowns. Furthermore, they have achieved 185 first downs but have incurred 32 penalties, resulting in 329 yards lost. They have turned the ball over 8 times this season.
On defense, the Tigers have given up 1,114 passing yards, ranking them 16th in Division 1. They are allowing an average of 159.1 yards per game through the air, maintaining a completion rate of 54.1% against them. With a season average of 243.0 yards allowed per game, they sit in 5th place nationally. The Tigers’ defense has conceded 9 passing touchdowns and 4 rushing touchdowns. Opponents have averaged 2.9 yards per rushing attempt, totaling 83.9 yards per game on the ground, with a cumulative 587 rushing yards given up across 7 games. Defensively, they rank 16th in scoring defense, allowing only 16.7 points per game.
The Vanderbilt Commodores also feature a 6-1 record this season. In their most recent contest, Vanderbilt triumphed over the LSU Tigers with a final score of 31-24. In that matchup, the Commodores averaged 5.3 yards per rushing attempt, totaling 239 yards on 45 carries. They compiled 399 yards while running 67 plays, averaging 6.0 yards per play. The Commodores’ secondary faced challenges, yielding a completion percentage of 67.9% and allowing 225 yards on 19 completions from 28 attempts. They also surrendered 100 rushing yards on 21 carries, averaging 4.8 yards per rush.
Vanderbilt’s offense is impressive as they average 457.7 yards per game, ranking them 25th in Division 1. The Commodores have incurred 443 yards in penalties across 48 infractions this season, positioning them 39th nationally in this statistic. Their rushing attack averages 213.0 yards per game, resulting in a total of 1,491 rushing yards this year. Despite throwing 4 interceptions and losing 2 fumbles, they have achieved 167 first downs. In terms of points, Vanderbilt ranks 8th in Division 1, scoring an average of 41.4 points per game. They have amassed 1,713 passing yards, averaging 244.7 yards through the air per game, landing them 57th in Division 1.
Defensively, the Commodores allow 20.0 points per game, placing them 35th in the nation. They have conceded 645 total rushing yards (92.1 yards per game) and 3 rushing touchdowns this season. Additionally, they have allowed 13 passing touchdowns and an average of 222.9 yards per game, ranking 72nd nationally. The Vanderbilt defense has been on the field for 418 plays, ranking 25th in Division 1, recording 6 fumble recoveries and 4 interceptions thus far, allowing a total of 140 points.
Which team will prevail in this Tigers vs. Commodores matchup against the spread?
My Prediction: Bet on the Tigers +2.5
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