New York Yankees and Baltimore Orioles Prediction for 9/21/2025 MLB Picks, Best Bets & Odds

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• Matchup: New York Yankees vs. Baltimore Orioles
• Date: Sunday, September 21, 2025
• Venue: Oriole Park at Camden Yards, Baltimore, MD
• Broadcasting: MASN
• Betting Odds: New York (-150) Baltimore (+125)

This Sunday, the Baltimore Orioles (72-81) will take on the New York Yankees (86-67) at Oriole Park at Camden Yards. The betting odds favor New York at -150, while Baltimore is set at +125. The over/under for the match is set at 9. Anticipated starting pitchers are Carlos Rodon and Tomoyuki Sugano.

The New York Yankees feature an impressive offense, averaging 5.2 runs per game, ranking them first in Major League Baseball. The team has scored a total of 801 runs with an on-base percentage (OBP) of .331. With 247 doubles and 258 home runs, the Yankees boast 773 RBIs and 1,296 hits this season, holding a batting average of .250. Their slugging percentage stands at .455, with 1,370 strikeouts and 597 walks drawn throughout the campaign.

The Yankees’ strikeout to walk ratio is 2.56, while the pitching staff has a collective WHIP of 1.27. This season, Yankees pitchers have surrendered 166 home runs and a total of 666 runs (ranked 16th in MLB). They have allowed 1,192 hits, equating to 7.9 per 9 innings, and have an earned run average (ERA) of 4.03 (18th in MLB) with 1,358 strikeouts. The bullpen has had 95 holds this year (7th in MLB) with a 66.1% save rate in 159 save chances, achieving 41 saves while failing 21 times. Out of 245 inherited runners, 28.2% have scored. This season, a total of 503 relievers have been sent to the mound.

The New York Yankees have achieved 4,049 putouts, along with 1,316 assists and 88 errors. Their fielding percentage is .984, placing them 24th in MLB, with 104 double plays executed. New York has transformed 70.3% of balls put into play into outs over 12,147 innings, ranking 12th in the league.

Carlos Rodon (career record 91-72) features a FIP of 3.69 and has faced 5,328 hitters in his career. He has allowed 1,077 hits (7.6 hits per 9 innings) and issued 475 walks. His ERA stands at 3.75 (528 ER allowed), and his WHIP is 1.224 over 1,268 innings, accompanied by 1,396 strikeouts throughout his time in professional baseball.

The Baltimore Orioles have a team slugging percentage of .398 and score an average of 4.25 runs per game (23rd in MLB). This season, they have recorded 243 doubles, drawn 451 walks, and accumulated 650 runs. With 180 home runs, they have achieved 617 RBIs, while suffering 1,369 strikeouts (4th in the league) and gathering a total of 1,224 hits. Their on-base percentage sits at .307, and their batting average is .238.

On the pitching side, the Baltimore staff has allowed 745 runs, maintaining an ERA of 4.61 (with 693 earned runs). They have given up 202 home runs, allowing 4.95 runs per 9 innings (24th in MLB). The team’s WHIP is 1.371 with a FIP of 4.41 this season. They have a strikeout to walk ratio of 8.40 (1,264 strikeouts to 496 walks) and rank 28th in total hits allowed with 1,359.

The Orioles’ relievers have an inherited score rate of 26.2% from 206 inherited runners. They have entered 163 high-leverage situations and have faced runners on base 148 times, achieving 103 holds and 20 blown saves out of 164 save situations. Ranked 10th in MLB with a save rate of 64.9%, they have used 512 bullpen pitchers so far this year. The Orioles’ bullpen has had 57 save opportunities, converting 37 saves successfully.

Defensively, the Baltimore Orioles have recorded 113 double plays with a fielding percentage of .985 (19th in the majors). They have a total of 1,336 assists, 83 errors, and achieved 4,034 putouts this season. Their defensive efficiency stands at 68.5% over 12,102 innings (26th in the majors).

In his career, Tomoyuki Sugano has allowed 162 hits, recording 100 strikeouts over 149 innings. With a win-loss record of 10-8, he boasts a 4.40 ERA and has allowed 9.8 hits per nine innings. Sugano has surrendered 73 earned runs, maintaining a WHIP of 1.320 and a FIP of 4.3, with a strikeout to walk ratio of 2.86 against 640 career hitters.

Who do you think will claim victory in this MLB contest, either against the spread or on the moneyline?

Prediction: Bet on Baltimore (+125)