New York Yankees versus Minnesota Twins Prediction, 9/16/2025 MLB Picks, Best Bets and Odds

Home » New York Yankees versus Minnesota Twins Prediction, 9/16/2025 MLB Picks, Best Bets and Odds

Matchup: New York Yankees vs Minnesota Twins

Scheduled Date: Tuesday, September 16, 2025

Venue: Target Field, Minneapolis, MN

Broadcast: Twins.TV

Betting Odds: New York (-150), Minnesota (+125)

On Tuesday, the Minnesota Twins (65-84) will face off against the New York Yankees (83-66) at Target Field. The betting line favors the Yankees at -150, with the Twins listed at +125. The total runs for this game are set at 8.5. The starting pitchers are expected to be Cam Schlittler for New York and Zebby Matthews for Minnesota.

MLB predictions for Minnesota Twins featuring Austin Martin

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The New York Yankees boast an impressive 5.2 runs per game, positioning them as the highest-scoring team in the league. So far, they have accumulated 774 total runs and maintain an on-base percentage (OBP) of .329. The Yankees have recorded 235 doubles and blasted 254 home runs this season. They have also generated 747 RBIs and 1,257 hits, resulting in a team batting average of .249. With a slugging percentage of .454, they have struck out 1,333 times while drawing 578 walks.

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On the pitching front, the Yankees currently hold a team ERA of 4.00, ranking 16th in the league, while fanning off 1,320 batters. They have surrendered 162 home runs and allowed 645 runs total (also 16th in baseball). The pitching staff has walked 518 hitters, and their FIP stands at 4.04. New York has conceded 1,160 hits (averaging 7.9 hits per 9 innings) and 588 earned runs, maintaining a strikeout-to-walk ratio of 2.55 along with a WHIP of 1.27.

This season, Yankees pitchers have entered with runners on base 156 times and faced 152 high-leverage situations. The relief squad has recorded 92 holds (8th in MLB) with a 65.6% save percentage out of 154 opportunities. They have secured 40 saves but experienced 21 blown saves out of 61 attempts. Additionally, Yankees relievers have inherited 239 baserunners, with 28.0% scoring. This year, the team has deployed 490 relievers.

The Yankees have converted 70.4% of balls put in play into outs across 11,913 innings, placing them 10th in the majors. They have registered 3,971 putouts, 1,289 assists, and committed 87 errors, leading to a fielding percentage of .984, which ranks 25th in the league, alongside 99 double plays turned.

Schlittler has pitched a total of 56 innings, striking out 63 batters in his MLB career. Currently holding a 3-3 career record, he has a FIP of 3.01 having faced 236 batters. Schlittler’s earned run average (ERA) stands at 3.05 (allowing 19 earned runs), coupled with a WHIP of 1.321. He has permitted 50 hits (8.0 per 9 innings) and issued 24 walks.

Meanwhile, the Minnesota Twins have a slugging percentage of .399 and score 4.24 runs per game, ranking 24th in MLB. They have tallied 227 doubles, earned 463 walks, and accumulated 632 runs. In terms of power, Minnesota has hit 178 home runs along with 600 RBIs. The team has been whiffed 1,239 times (16th in the league) and currently stands with 1,199 hits. The Twins have achieved an OBP of .313 and a batting average of .239 this season.

The Twins own a team WHIP of 1.332, with a FIP of 4.15 collectively. They have a strikeout-to-walk ratio of 8.60 (with 1,252 strikeouts to 426 walks). As a pitching unit, they rank 25th in the league by allowing 1,320 hits, alongside giving up 180 home runs, averaging 4.95 runs per 9 innings (24th in MLB). The Twins’ pitching staff has recorded a 4.61 ERA, conceding 721 runs (672 earned runs).

In their bullpen, the Twins have an inherited score percentage of 35.8%, dealing with 162 inherited runners. Minnesota’s relievers have engaged in 165 high-pressure situations and faced 112 innings with runners on base. With 142 save opportunities, the Twins’ bullpen has achieved 89 holds, but experienced 24 blown saves. They rank 28th in the league with a 52.9% save percentage and employed 503 relievers throughout the season, achieving 27 saves out of 51 opportunities.

In the field, the Twins have a defensive efficiency of 68.1% (29th in MLB) over 11,799 innings. They have executed 90 double plays and maintain a fielding percentage of .985 (18th in MLB). The team has registered 1,119 assists, 77 errors, and 3,933 putouts on the season.

Cam Schlittler faces an interesting matchup tonight. He has given up 130 hits while notching 123 strikeouts over 106 innings pitched. With a 5-9 career record, Matthews’ earned run average stands at 5.67, allowing 11.0 hits per nine innings. He has granted 67 earned runs, sporting a WHIP of 1.533 and a FIP of 5.6, alongside a strikeout-to-walk ratio of 3.73, facing 482 opposing batters so far in his MLB journey.

Will the Twins secure a win tonight against the spread or the moneyline?

Guy Bruhn’s Prediction: Bet on Minnesota (+125)

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