New York Yankees vs Baltimore Orioles Prediction for 9/20/2025 MLB Picks, Best Bets & Odds

• Matchup: New York Yankees vs Baltimore Orioles
• Date: Saturday, September 20, 2025
• Venue: Oriole Park at Camden Yards, Baltimore, MD
• Television: MASN
• Betting Odds: New York Yankees (-144), Baltimore Orioles (+120)

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The Baltimore Orioles (72-80) are set to host the New York Yankees (85-67) at Oriole Park at Camden Yards this Saturday. The moneyline for this matchup has New York at -144 and Baltimore at +120, with the over/under set at 8.5 runs. Pitchers Carlos Rodon and Tomoyuki Sugano will take the mound for their respective teams.

This season, the Yankees boast a slugging percentage of .455, with a total of 1,359 strikeouts and 589 walks drawn. They have accumulated 766 RBIs and 1,287 hits, leading to a team batting average of .250. New York has achieved 243 doubles and hit 258 home runs, while scoring 794 runs, placing them first in the MLB in average runs per game at 5.2.

The Yankees have recorded a team earned run average of 4.05 this season, ranking 18th in the league, with 1,343 batters struck out. Yankees pitchers have allowed 166 home runs and a total of 666 runs (16th in the league). They have issued 528 walks and possess a team FIP of 4.05. New York has given up 1,189 hits (7.9 hits allowed per 9 innings) with a total of 608 earned runs. Their strikeout-to-walk ratio stands at 2.54, and their collective WHIP is 1.27.

This season, the Yankees have utilized 502 relievers. The bullpen has inherited 245 runners, of whom 28.2% have scored. They have successfully completed 41 saves out of 62 attempts, giving them a save percentage of 66.1%. Yankees relief pitchers have been called upon in 159 save opportunities, achieving 95 holds thus far (ranked 7th in the league). They have handled 160 appearances with runners on base and 156 in high-leverage situations.

Defensively, the Yankees have converted 70.3% of balls put into play into outs over 12,147 innings, ranking 12th in the league. The New York Mets have registered 4,049 putouts, with 1,316 assists and 88 errors so far this season. Their fielding percentage sits at .984, which ranks 24th in professional baseball, and they have turned 104 double plays.

Career-wise, Rodon has thrown 1,268 innings with 1,396 strikeouts. His career record stands at 91-72, with a FIP of 3.69 against 5,328 batters faced. Rodon’s earned run average is 3.75 (528 earned runs) with a WHIP of 1.224, having allowed 1,077 hits (7.6 hits per 9 innings) and issued 475 walks.

The Orioles have hit 180 home runs this year and driven in 617 runs. They have hit 243 doubles, drawn 449 walks, and scored 650 runs. The Baltimore Orioles have an on-base percentage of .307 along with a team batting average of .239 throughout this season. Their slugging percentage is .400, and they average 4.28 runs per game, placing them 19th in the league. The Orioles have struck out 1,354 times (ranked 4th) and recorded 1,221 hits.

This season, the Baltimore pitching staff has allowed 738 runs, maintaining a team ERA of 4.59 (686 earned runs). They have given up 202 home runs and relinquished 4.94 runs per 9 innings (24th in the league). Baltimore’s team WHIP is 1.367, with a FIP of 4.42 across the pitching staff, boasting a K/BB ratio of 8.40 (1,253 strikeouts against 488 walks). They rank 27th in the league for total hits allowed with 1,350.

In the bullpen, Baltimore relievers have allowed 26.3% of inherited runners to score, from a total of 205. They have appeared in 163 high-leverage situations and 147 times with runners on base. Out of 164 save opportunities, the Orioles have secured 37 saves, with 103 holds and 20 blown saves, ranking 10th in the league with a save percentage of 64.9%. The team has deployed 508 relievers this season.

Over the course of 12,102 innings, the Orioles have a defensive efficiency of 68.5%, ranked 26th in professional baseball. They’ve turned 113 double plays and carry a fielding percentage of .985 (19th overall). This season, they have recorded 1,336 assists, 83 errors, and tallied 4,034 putouts.

In his professional career, Sugano has allowed 162 hits and achieved 100 strikeouts over 149 innings pitched. With a career record of 10-8, he maintains a 4.40 earned run average, allowing 9.8 hits per 9 innings and giving up 73 earned runs. His WHIP is 1.320, and his FIP stands at 4.3. Sugano’s K/BB ratio is 2.86 against 640 batters faced during his career.

Who will emerge victorious in tonight’s MLB contest against the spread or moneyline?

Pick by Josh Schonwald: Back Baltimore (+120)