Notre Dame Fighting Irish vs Louisville Cardinals Prediction, February 4, 2026 College Basketball Picks, Best Bets & Odds

Home » Notre Dame Fighting Irish vs Louisville Cardinals Prediction, February 4, 2026 College Basketball Picks, Best Bets & Odds

  • Matchup: Notre Dame Fighting Irish vs. Louisville Cardinals
  • Date: Wednesday, February 4, 2026
  • Venue: KFC Yum! Center, Louisville, KY
  • Broadcast: ESPN2

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In the KFC Yum! Center, the Louisville Cardinals (15-6) are set to face the Notre Dame Fighting Irish (11-11) on Wednesday night.

College Basketball Predictions for Notre Dame Fighting Irish

In their previous game, the Fighting Irish took on Syracuse but fell short, losing 86-72. Notre Dame committed 16 fouls while Syracuse had 18. The Irish converted 10 out of 25 three-point attempts. Syracuse managed a free throw percentage of 57.1%, making 12 of 21 shots. Syracuse recorded 32 rebounds (5 offensive, 27 defensive) and had no blocks. They also provided 21 assists and tallied 7 steals. Defensively, Notre Dame allowed Syracuse to shoot 57.1% from the field on 32 of 56 attempts, while Notre Dame achieved 49.1% shooting from the floor (26 of 53) and dropped 6 out of 22 from three-point range.

Jalen Haralson was a standout player, scoring 26 points on 9 of 12 shooting in 31 minutes and contributing 2 rebounds and 4 assists.

Entering this matchup, Notre Dame holds an 11-11 record this season. The team averages 11.5 turnovers and commits 17.5 personal fouls each game. They secure 37.1 rebounds per contest and have accumulated 264 assists so far, ranking them 323rd in Division 1 basketball. The Fighting Irish nail 35.2% of their three-point attempts (185 of 526) and shoot 69.9% from the free-throw line. They score an average of 74.0 points per game, placing them 245th nationally, while shooting at 45.0% from the floor.

Defensively, Notre Dame forces 9.4 turnovers per game and commits 17.9 personal fouls. Your Fighting Irish rank 152nd in Division 1 for assists allowed, with 290 given up this season. They hold opponents to a shooting percentage of 43.2% (542 of 1,255) and average 32.2 rebounds surrendered. Opponents convert 31.8% of their three-point attempts while Notre Dame ranks 141st in points allowed per game (72.2).

Most recently, the Louisville Cardinals secured a victory against SMU, winning 88-74. Louisville allowed SMU to grab 34 rebounds (9 offensive). The Cardinals shot 32.0% from beyond the arc (8 of 25) and made 6 of 9 free-throw attempts (66.7%). SMU hit 30 of 62 shots from the floor, achieving a 48.4% shooting rate. Louisville ended the game with a field goal percentage of 49.2%, converting 31 of 63 attempts and 28.6% from three-point territory with 10 makes out of 35 tries.

Mikel Brown Jr. emerged as a key player for Louisville, scoring 20 points in 29 minutes with 4 assists and shooting 50.0% (7 of 14) along with 3 rebounds.

Louisville boasts a 15-6 overall record this season. The Cardinals commit 18.9 fouls each game and enjoy a free throw percentage of 76.5%. They average 17.6 assists per game, ranking 24th in college basketball, with turnovers averaging 11.5 per game. This season, Louisville has scored 1,808 points (86.1 per game) and collects 40.4 rebounds per contest while shooting 46.3% from the field, placing them 126th nationwide.

Defensively, the Cardinals rank 90th in points allowed per game (70.5), forcing 12.8 turnovers per game and holding opponents to a shooting percentage of 40.4% (35th in Division 1). They allow opponents to hit 33.5% of their three-point attempts (172 of 514) and 70.6% from the free-throw line. Louisville gives up an average of 11.5 assists and 34.2 rebounds per game, ranking 49th and 168th respectively.

Who will emerge victorious in tonight’s NCAA matchup against the spread?

Prediction: Take Louisville

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Pick: Louisville Cardinals
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