Penn State Nittany Lions vs Ohio State Buckeyes Prediction, College Football Picks, Best Bets & Odds for 11/1/2025

Home » Penn State Nittany Lions vs Ohio State Buckeyes Prediction, College Football Picks, Best Bets & Odds for 11/1/2025

  • Matchup: Penn State Nittany Lions vs. Ohio State Buckeyes
  • Date: Saturday, November 1, 2025
  • Venue: Ohio Stadium, Columbus, OH
  • Broadcast: FOX
  • Point Spread: Buckeyes favored by 20.5 points
  • Over/Under Total: 43.5

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The Ohio State Buckeyes (7-0) are set to clash with the Penn State Nittany Lions (3-4) on Saturday, November 1, 2025, at Ohio Stadium. Ohio State is entering the game as significant favorites, with a spread of 20.5 points, while the over/under is pegged at 43.5.

Currently, the Penn State Nittany Lions sit at 3-4 for the season. In their most recent outing, they faced the Iowa Hawkeyes, narrowly suffering a 25-24 defeat. During this matchup, Penn State allowed 245 rushing yards on 33 carries, averaging 7.4 yards per rush. In the air, they permitted 10 completions out of 16 attempts for a total of 68 yards, achieving a completion percentage of 62.5%. Overall, the Nittany Lions executed 74 plays, accumulating 266 yards. They carried the ball 46 times, totaling 173 yards and averaging 3.8 yards per attempt.

Nicholas Singleton of the Penn State Nittany Lions - College Football Predictions and Betting Odds

This season, the Nittany Lions have amassed a total of 2,485 yards. In terms of touchdowns, they’ve scored 9 through the air and 17 on the ground while tallying 7 turnovers. The team has earned 141 first downs and received 27 penalties accounting for 219 yards. Their rushing average stands at 169.6 yards per game, ranking 55th nationally. They’re putting up an impressive average of 34.0 points per game.

Defensively, Penn State holds the 29th position in college football for points allowed, giving up an average of 19.4 per game. They’re allowing 4.1 rushing yards per carry and an average of 158.7 rushing yards per game, having surrendered a total of 1,111 rushing yards over 7 contests. In the passing game, they have yielded 1,015 yards, which places them 3rd nationally. Their average pass defense allows 145.0 yards per game with a completion rate of 61.7%, resulting in an average of 303.7 yards of total offense allowed, ranking them 20th in the country. They have allowed 8 touchdowns both on the ground and through the air.

The Ohio State Buckeyes come into this contest with an undefeated record of 7-0. Their last game ended in a dominant 34-0 victory over the Wisconsin Badgers. Ohio State managed 3.5 yards per carry on the ground, totaling 98 yards from 28 carries. They produced a remarkable 491 total yards across 70 plays, averaging 7.0 yards per play. The Buckeyes’ pass defense limited opponents to a 46.7% completion rate, yielding only 49 yards on 7 out of 15 passing attempts. They faced 31 rushing attempts, conceding 95 yards (3.1 yards per rush).

Averaging 431.4 yards per game, the Ohio State Buckeyes rank 36th in the nation. Their offense has incurred 264 yards of penalties across 32 infractions, ranking 126th in D-1. On the ground, they average 151.7 yards per game, totaling 1,062 rushing yards this season. This year, they’ve thrown 3 interceptions and lost 1 fumble, securing 157 first downs overall. Ohio State ranks 21st in scoring, averaging 36.4 points per game. They have thrown for a combined 1,958 yards, averaging 279.7 passing yards per game, which puts them 24th in D-1.

Defensively, Ohio State has allowed 599 rushing yards (85.6 yards per game) and just 1 rushing touchdown this season. They’ve given up 3 passing touchdowns, allowing 131.3 passing yards per game, ranking 3rd nationally. Overall, they’ve conceded just 41 points, with 5 fumbles and 4 interceptions on the season. Their defense has participated in a total of 398 plays, ranking 2nd in Division 1, while allowing an impressive 5.9 points per game, leading the nation.

Which team will prevail in this highly anticipated Nittany Lions/Buckeyes matchup against the spread?

Prediction: Consider taking the Nittany Lions +20.5

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Pick: Penn State Nittany Lions +20.5
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