Prediction for Colorado Buffaloes vs TCU Horned Frogs, College Football Picks, Best Bets & Odds for 10/4/2025

Home » Prediction for Colorado Buffaloes vs TCU Horned Frogs, College Football Picks, Best Bets & Odds for 10/4/2025

  • Matchup: Colorado Buffaloes vs TCU Horned Frogs
  • Date: Saturday, October 4, 2025
  • Venue: Amon G. Carter Stadium, Fort Worth, TX
  • Broadcast: FOX
  • Betting Odds: Horned Frogs favored by 14.0 points
  • Total Points Line: 58.5

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On Saturday, October 4, 2025, Amon G. Carter Stadium will host the Colorado Buffaloes (2-3) facing off against the TCU Horned Frogs (3-1). TCU is entering the game as 14.0-point favorites according to the latest odds, with the over/under set at 58.5.

The Colorado Buffaloes enter this contest sporting a 2-3 record this season. In their last appearance, the Buffaloes battled against the BYU Cougars, ultimately succumbing with a score of 24-21. Colorado executed 37 rushing attempts, accumulating 172 yards at an average of 4.6 yards per carry. Overall, the team ran 53 plays, resulting in 291 total yards. On defense, they allowed 19 completions out of 29 attempts for 179 passing yards, giving up a completion rate of 65.5%. In addition, Colorado yielded 208 yards on 36 rushing attempts, averaging 5.8 yards per carry.

college football predictions Josh Hoover TCU Horned Frogs best bets odds

This season, the Buffaloes have gained a total of 1,791 yards. They have scored 8 touchdowns through the air and added 9 on the ground, with 4 turnovers recorded. The offense has achieved 95 first downs while incurring 26 penalties for a total of 250 yards. Colorado’s rushing game averages 147.4 yards per game, ranking 85th nationally. In terms of scoring, they average 25.8 points per contest.

On the defensive side, the Buffaloes have surrendered 1,038 passing yards, positioning them 82nd in Division 1. They allow 207.6 yards per game through the air, supporting a completion percentage of 56.6%. Overall, they permit an average of 404.8 yards per game, ranking them 111th in the nation. In total, they’ve allowed 5 touchdowns through the air and 7 on the ground, averaging 4.8 yards per carry and 197.2 rushing yards per game. Thus far, they have given up a total of 986 rushing yards in 5 games, placing them 62nd in D-1 for team defense with an allowance of 22.8 points per game.

The TCU Horned Frogs are approaching this game with a 3-1 record this season. In their last game, TCU faced a close defeat against the Arizona State Sun Devils, ending 27-24. In that contest, TCU’s run defense allowed 44 attempts for 201 yards (4.6 yards per carry). The Frogs’ passing defense recorded a completion rate of 69.2%, yielding 291 yards on 27 of 39 attempts. Overall, TCU registered 269 yards from 58 plays (4.6 yards per play), and they struggled in the rushing game with only 10 yards gained on 25 carries, averaging just 0.4 yards per attempt.

In terms of offense, the Frogs rank 30th in Division 1, averaging 37.3 points per game. They generate about 454.3 total yards per game, placing them 27th nationally. TCU’s offense has committed 26 penalties resulting in 241 yards, ranking them 73rd in the country for self-inflicted wounds. They have thrown 5 interceptions and lost 1 fumble while managing to secure 92 first downs. For the season, TCU has amassed 1,283 passing yards, averaging 320.8 yards through the air per game, which ranks 12th in college football. In the ground game, they average 133.5 yards per game totaling 534 rushing yards so far.

On defense, TCU has allowed a total of 522 rushing yards (130.5 yards per game) and 3 rushing touchdowns this season. They have given up 8 touchdowns through the air and an average of 257.3 passing yards per game, placing them 112th in the nation. Overall, they’ve surrendered 86 points. Their defensive unit has forced 3 fumbles and recorded 3 interceptions this year. TCU’s defense has been on the field for 272 plays, positioning them 46th in the nation with an allowance of 21.5 points per game, which ranks 55th in D-1.

Who will emerge victorious in this Buffaloes vs. Horned Frogs college football matchup against the spread?

Prediction: Bet on the Horned Frogs -14.0

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Pick: TCU Horned Frogs -14.0
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