- Matchup: Louisville Cardinals vs. Miami Hurricanes
- Date: Friday, October 17, 2025
- Venue: Hard Rock Stadium, Miami Gardens, FL
- Broadcast: ESPN
- Betting Line: Hurricanes favored by 13.5 points
- Points Total: 53
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The Louisville Cardinals, sporting a record of 4-1, are set to visit Hard Rock Stadium on Friday, October 17, 2025, aiming to triumph over the undefeated Miami Hurricanes, who currently sit at 5-0. The Cardinals are 13.5-point underdogs according to betting lines from Las Vegas, with the total points over/under established at 53.
Louisville enters this contest with a 4-1 record this season. In their latest outing against the Virginia Cavaliers, the Cardinals were narrowly defeated 30-27. On the offensive line, they allowed 88 rushing yards on 32 attempts, resulting in an average of 2.8 yards per carry. The defense permitted 19 completions on 31 passes for a total of 149 passing yards, achieving a pass completion rate of 61.3%. In total, they executed 75 plays amounting to 383 yards, with 27 rushing attempts that garnered 54 yards, averaging 2.0 yards per rush.

In terms of scoring, the Louisville Cardinals are averaging 36.0 points per game. However, they struggle on the ground, generating only 115.0 rushing yards per game, ranking 113th nationally. Overall, they have accumulated 2,020 total yards this season, including 8 passing touchdowns and 10 rushing touchdowns. They have achieved 110 first downs but have incurred 37 penalties totaling 362 yards, along with 8 turnovers.
From a defensive standpoint, the Cardinals rank 48th nationally, allowing 21.0 points per game. Opponents are averaging 3.3 yards per carry and 111.6 rushing yards per game, amounting to 558 rushing yards allowed in total over five games. Through the air, Louisville has conceded 752 passing yards, averaging 150.4 yards allowed per game with a completion percentage against of 54.3%. Overall, they have yielded 262.0 total yards per game, placing them 12th in Division 1, allowing 5 passing touchdowns and 4 rushing touchdowns this season.
The Miami Hurricanes are enjoying a 5-0 record this season. In their previous matchup, they secured a 28-22 victory over the Florida State Seminoles. Miami accumulated a total of 338 yards from 59 plays, averaging 5.7 yards per play. They rushed for 97 yards on 32 attempts, averaging 3.0 yards per carry, while allowing the opponent 132 rushing yards on 38 attempts (3.5 yards per carry). Their pass defense yielded a completion rate of 55.6%, allowing 272 yards through the air on 25 of 45 attempts.
In the scoring department, Miami ranks 35th in Division 1 with an average of 35.0 points per game. They generate around 428.0 yards per game, placing them 41st in the nation. The Hurricanes have committed 38 penalties, resulting in 314 yards lost, ranking them 59th nationwide. They have had 3 interceptions with no fumbles lost and have converted 113 first downs. This season, Miami has thrown for a total of 1,321 yards, averaging 264.2 passing yards per game, which places them 39th nationally. On the ground, they average 163.8 rushing yards per game with a season total of 819 rushing yards.
Defensively, the Hurricanes give up only 13.6 points per game, ranking them 9th in the nation. They have allowed a total of 437 rushing yards (87.4 yards per game) with 2 rushing touchdowns. In the passing game, Miami has relinquished 5 touchdowns and an average of 189.0 passing yards per game, ranking them 35th in the country. Their defense has been active on the field for 312 plays, placing them 2nd nationally. For this season, they have forced 4 fumbles and secured 5 interceptions, allowing a total of 68 points.
Who will cover the spread in the Cardinals vs. Hurricanes college football clash?
Prediction: Bet on the Hurricanes -13.5
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