San Diego Padres and St. Louis Cardinals Prediction for 7/26/2025 MLB Picks, Best Bets & Odds

Home » San Diego Padres and St. Louis Cardinals Prediction for 7/26/2025 MLB Picks, Best Bets & Odds

Game: San Diego Padres vs. St. Louis Cardinals

Date: Saturday, July 26, 2025

Location: Busch Stadium, St. Louis, MO

Broadcast: FanDuel Sports Network Midwest

Betting Odds: San Diego (-182) St. Louis (+150)

The St. Louis Cardinals (52-51) are set to face off against the San Diego Padres (55-47) at Busch Stadium this Saturday. The moneyline for this matchup features San Diego at -182 and St. Louis at +150. A total of 8.5 runs has been established for this game. Randy Vasquez and Matthew Liberatore are the likely starting pitchers.

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The Padres have recorded 153 doubles as a team and hit 86 home runs this season. With a slugging percentage of .374, they have struck out 717 times while walking 326 times. On average, the San Diego Padres are scoring 4.0 runs per game, ranking 25th in the league. They’ve tallied 382 RBIs and 830 hits with a batting average of .245. Their on-base percentage stands at .314 with 407 runs scored.

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The strikeout-to-walk ratio for the Padres is 2.58, and their pitching staff holds a WHIP of 1.23. Padres pitchers have surrendered 100 home runs and allowed 391 runs, ranking 5th in Major League Baseball. San Diego has conceded 773 hits (7.7 per 9 innings) alongside 358 earned runs, holding a team ERA of 3.58 (5th in MLB) while striking out 868 batters. They’ve issued 336 walks with a FIP of 3.86 throughout the season.

The Padres’ bullpen boasts a 74.5% save success rate, having been called in 119 save situations. This season, relievers have inherited 170 base runners, with 30.0% scoring. San Diego’s relief pitchers have entered the game 122 times with runners on base and have appeared in 149 high-leverage situations. Across the season, the Padres have utilized 357 relief pitchers, securing 70 holds—ranking 6th in the league—and achieving 35 saves from 47 opportunities.

In their 8,109 innings on the field, the Padres have converted 71.0% of balls in play into outs, placing them 8th in MLB. They’ve tallied 2,703 putouts alongside 774 assists and 51 errors, with a fielding percentage of .986, ranking 21st in the league and recording 76 double plays.

Randy Vasquez has pitched 234 innings in his MLB career, amassing 145 strikeouts with a 4.07 ERA (106 earned runs). His WHIP stands at 1.435 as he’s allowed 242 hits (9.3 per 9 innings) and 94 walks. With a career record of 9-13, his FIP is recorded at 4.01 versus 1,028 opposing batters.

The Cardinals own a slugging percentage of .393 and average 4.48 runs per game (13th in MLB). They have 182 doubles, 319 walks, and have driven in 461 runs, with 100 home runs to their name. They’ve struck out 794 times (25th in the league) and totaled 881 hits this season. St. Louis holds an OBP of .321 along with a batting average of .252.

With a team WHIP of 1.286, the Cardinals have a FIP of 3.86. They currently rank 24th in MLB for hits allowed, conceding 890. The Cardinals’ pitching staff has surrendered 465 runs this season, holding a team ERA of 4.22 (426 earned runs). Their strikeout-to-walk ratio is 7.50 (754 strikeouts to 279 walks), allowing 99 home runs and giving up 4.60 runs per 9 innings (22nd in MLB).

In 98 save situations, the Cardinals have recorded 57 holds and have experienced 14 blown saves. Their relievers have entered 38 save opportunities, successfully securing 24 saves. They’ve made 102 high-leverage appearances and 99 with runners on base. St. Louis relievers have inherited a score percentage of 34.3% from 134 inherited runners, ranking 15th in MLB with a 63.2% save percentage. They’ve called on 306 relief pitchers this season.

The St. Louis Cardinals have executed 78 double plays and hold a .989 fielding percentage, ranking 4th in MLB. They have registered 991 assists, 41 errors, and 2,729 putouts across 8,187 innings, showcasing a defensive efficiency of 69.6% (17th in professional baseball).

Matthew Liberatore, with a career record of 14-19, has posted a 4.69 earned run average while allowing 9.3 hits per 9 innings. His K/BB ratio stands at 2.47, having faced 1,216 batters in his career. Liberatore has given up 147 earned runs with a WHIP of 1.364 and a FIP of 4.6. He has allowed 292 hits while collecting 230 strikeouts over 282 innings pitched.

Who will emerge victorious in tonight’s MLB matchup against the spread or moneyline?

Pundit’s Pick: Take St. Louis (+150) and the under on 8.5 runs

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