- Matchup: San Francisco 49ers vs Arizona Cardinals
- Date: Sunday, November 16, 2025
- Venue: State Farm Stadium, Glendale, AZ
- Broadcast: FOX
- Point Spread: Cardinals (+2.5)
- Total Points (Over/Under): 49
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This Sunday, the Arizona Cardinals (3-6) will host the San Francisco 49ers (6-4) at State Farm Stadium, coming in as 2.5-point underdogs according to betting lines. The game total is set at 49 points.
The 49ers have a 6-4 record this season. In their most recent outing, they faced the Los Angeles Rams but came away with a disappointing 42-26 defeat. Quarterback Mac Jones completed 33 of 39 passes for 319 yards and 3 touchdowns, achieving a quarterback rating of 115.7, though he did throw one interception. Wide receiver Kendrick Bourne averaged 19.0 yards per catch with 1 reception for 19 yards. Running back Christian McCaffrey led the ground game with 12 carries for just 30 yards (2.5 yards per carry). The team ran a total of 60 plays and accumulated 393 yards. The rushing game managed 74 yards over 21 attempts, averaging 3.5 yards per carry, while the 49ers’ defense allowed 126 rushing yards on 30 attempts, averaging 4.2 yards per carry. San Francisco’s secondary allowed 24 completions on 36 attempts for a total of 275 yards, resulting in a completion rate of 66.7%.
This season, the 49ers have amassed a total of 3,562 yards, averaging 139 first downs and committing 61 penalties for 467 yards. In terms of touchdowns, they have scored 17 through the air and 6 on the ground while fumbling the ball 15 times (10 interceptions and 5 fumbles). The team averages 94.8 rushing yards per game, ranking them 27th in the league, and they score an average of 22.0 points per game.
On the defensive side, the 49ers have allowed 2,288 passing yards, placing them 26th in the league, while surrendering 228.8 yards per game and a completion percentage of 67.8%. They have conceded a total of 1,106 rushing yards in 10 games, giving up 19 passing touchdowns and 7 rushing touchdowns. Overall, the defense allows an average of 339.4 yards per game, ranking 21st in the league, and they yield an average of 4.2 yards per carry, along with 110.6 rushing yards per game. They rank 15th overall in terms of defensive efficiency, giving up 23.0 points per game.
The Arizona Cardinals enter this game with a record of 3-6. In their latest contest, they suffered a 44-22 defeat against the Seattle Seahawks. Quarterback Jacoby Brissett threw for 258 yards and 2 touchdowns on 22 of 44 passing, achieving a quarterback rating of 83.3 without any interceptions and averaging 5.9 yards per attempt. Emari Demercado was the standout receiver, catching 3 passes for 40 yards (13.3 yards per reception). Running back Zonovan Knight managed 10 carries for 28 yards, averaging 2.8 yards per carry. The Cardinals finished the game with 335 total yards and ran 68 plays, averaging 4.9 yards per play. They rushed for 5.6 yards per attempt, totaling 129 yards on 23 carries. Conversely, they allowed the Seahawks 198 rushing yards on 46 attempts (4.3 yards per rush) and had a pass defense completion rate of 83.3%, allowing 174 yards on 10 of 12 passing.
The Arizona Cardinals are averaging 316.3 yards per game, which ranks them 21st in the league. They have 113.4 rushing yards on average, accumulating a total of 1,021 rushing yards. The offense has committed 4 interceptions and lost 6 fumbles, resulting in 107 first downs. They have also incurred 61 penalties leading to 440 total yards, ranking 20th in the league in this category. The Cardinals have accumulated 1,826 passing yards, averaging 202.9 passing yards per game, placing them 21st in the NFL. They currently average 22.4 points per game, landing them at 20th in the league in scoring.
Defensively, the Cardinals allow 23.9 points per game, which ranks 19th in the league. They have conceded 10 passing touchdowns while allowing an average of 225.3 passing yards and ranking 20th overall. On the ground, they’ve given up a total of 1,027 rushing yards (114.1 yards per game) and 9 rushing touchdowns. Their defense has participated in 572 plays, ranking them 19th in the league, and has forced 13 turnovers (7 fumble recoveries and 6 interceptions) this season, resulting in 215 points surrendered.
Who will emerge victorious in tonight’s clash between the 49ers and Cardinals?
Tip: Choose the 49ers -2.5
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