- Matchup: San Francisco 49ers vs. Indianapolis Colts
- Game Date: Monday, December 22, 2025
- Venue: Lucas Oil Stadium, Indianapolis, IN
- Broadcast: ESPN
- Betting Odds: Colts (+6)
- Over/Under Total: 46.5
This page may include affiliate links at no extra cost to you, thanks for your support.
On Monday, Lucas Oil Stadium will host an exciting matchup between the Indianapolis Colts (8-6) and the San Francisco 49ers (10-4). The Colts enter as 6-point underdogs according to Vegas odds, with a total set at 46.5 points.
The 49ers come into this contest boasting a 10-4 record for the season. Their most recent game saw them triumph over the Tennessee Titans, clinching a victory with a score of 37-24. Quarterback Brock Purdy completed 23 of 30 passes for 295 yards and 3 touchdowns, achieving a remarkable QB rating of 140.3 while avoiding any interceptions. Christian McCaffrey led the rushing attack with 22 carries for 73 yards (averaging 3.3 yards per attempt). George Kittle contributed significantly with 8 receptions for 88 yards, averaging 11.0 yards per catch. The 49ers executed 38 rushing plays, gathering a total of 138 yards (3.6 yards per carry), finishing with 68 total plays for 430 yards. Defensively, San Francisco allowed 18 completions on 29 attempts, totaling 170 yards with a completion percentage of 62.1%. Against the run, they conceded 136 yards on 20 attempts, averaging 6.8 yards per carry.
In terms of scoring, the San Francisco 49ers are averaging 24.6 points per game. They currently rank 25th in the league with 101.4 rushing yards per game and have amassed a total of 4,865 yards this season. Offensively, the 49ers have achieved 192 first downs and committed 73 penalties totaling 529 yards. They have turned the ball over 19 times, with 13 interceptions and 6 fumbles lost. In the pursuit of touchdowns, the 49ers have reached the end zone 25 times through the air and 12 times on the ground.
Defensively, the 49ers rank 11th in the league, allowing an average of 20.9 points per game. They permit 4.3 rushing yards and 106.1 total rushing yards per game this season. In the passing game, they’ve given up 3,186 yards, ranking them 22nd in the NFL while allowing 227.6 passing yards per game and a completion rate of 68.8%. Overall, San Francisco yields 333.6 yards per game, ranking them 18th. They have allowed 25 passing touchdowns and 9 rushing touchdowns, totaling 1,485 rushing yards allowed over 14 games this season.
The Colts head into this matchup with a record of 8-6 for the season. In their last outing, they faced a narrow defeat against the Seattle Seahawks, ending the game at 18-16. Jonathan Taylor was a key contributor, carrying the ball 25 times for 87 yards, averaging 3.5 yards per carry. Receivers saw Ameer Abdullah catch 5 passes totaling 32 yards (6.4 yards per reception). Quarterback Philip Rivers finished 18 of 27 for 120 yards with 1 touchdown and a QB rating of 73.1. He threw 1 interception, averaging 4.4 yards per attempt. On the defensive side, the Colts allowed the Seahawks to rush 22 times for 50 yards (2.3 yards per carry). In passing defense, they gave up a completion percentage of 61.1%, allowing 264 yards on 22 completions out of 36 attempts. The Colts completed the game with 215 total yards, having run 57 plays (averaging 3.8 yards per play) and achieving 97 rushing yards on 30 attempts (3.2 yards per carry).
In terms of offensive performance, the Colts rank 6th in the league, scoring an average of 28.0 points per game. For the season, they have accumulated 3,206 passing yards, averaging 229.0 yards per game through the air, placing them 9th overall. On the ground, they average 128.5 rushing yards per game, contributing to a total of 1,799 rushing yards. With an average of 357.5 total yards per game, the Colts rank 8th in the NFL. Offensively, Indianapolis has been penalized for 699 yards on 86 infractions, ranking 24th for mistakes that harm team performance. They have turned the ball over 10 times with 6 fumbles lost and successfully achieved 166 first downs.
Defensively, Indianapolis has conceded 18 passing touchdowns while allowing 247.6 passing yards per game, securing a rank of 31st in the league. They have given up a total of 1,332 rushing yards (averaging 95.1 rushing yards per game) along with 13 rushing touchdowns this season. The Colts defense has collected 18 takeaways (6 forced fumbles and 12 interceptions) throughout the year. Overall, they have allowed 303 points, with a total of 916 defensive plays, placing them 31st in the league. The Colts currently allow an average of 21.6 points per game, ranking them 12th in the NFL.
Who is poised to win tonight’s matchup between the 49ers and Colts against the spread?
Prediction: Opt for the Colts +6
Some links on this page are affiliate links. If you sign up or make a purchase through them, we may earn a small commission always at no extra cost to you. Thanks for helping us keep this site running.
