San Francisco 49ers vs Seattle Seahawks Prediction for 1/17/2026 NFL Picks, Best Bets & Odds

Home » San Francisco 49ers vs Seattle Seahawks Prediction for 1/17/2026 NFL Picks, Best Bets & Odds

  • Matchup: San Francisco 49ers vs Seattle Seahawks
  • Event Date: Saturday, January 17, 2026
  • Venue: Lumen Field, Seattle, WA
  • Broadcast: FOX
  • Point Spread: Seahawks (-7.5)
  • Over/Under Total: 44.5

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The San Francisco 49ers (12-5) are heading to Lumen Field this Sunday for an exciting NFC Divisional Playoff clash against the Seattle Seahawks (14-3). San Francisco enters this contest as 7.5-point underdogs, with the total set at 44.5.

Entering this matchup, the 49ers hold a record of 12-5. Their previous outing was a hard-fought victory against the Philadelphia Eagles, winning 23-19. Quarterback Brock Purdy completed 18 of 31 passes for 262 yards and two touchdowns, although he did record two interceptions, yielding a QB rating of 80.3. Christian McCaffrey showcased his skills with six receptions for 66 yards, averaging 11.0 yards per grab. Leading the 49ers’ rushing attack, McCaffrey totaled 48 yards on 15 carries, averaging 3.2 yards per rush. Overall, the team executed 57 plays, accumulating 361 total yards. The 49ers managed to rush 25 times for 75 yards, giving them a rushing average of 3.0 yards per attempt. Conversely, San Francisco’s defense allowed their opponents to rush for 140 yards on 36 attempts, averaging 3.9 yards per carry. They permitted 20 completions on 35 attempts, yielding 167 passing yards at a completion rate of 57.1%.

NFL predictions and best bets for Seattle Seahawks

So far this season, the 49ers have amassed a total of 5,974 offensive yards. They have achieved 237 first downs and have faced 83 penalties, resulting in 651 lost yards. Touchdown production consists of 33 touchdowns through the air and 15 on the ground. However, they have been prone to turnovers, with 22 total giveaways (16 interceptions and 6 fumbles). Their rushing game averages 106.9 yards per game, ranking 24th in the league. In terms of scoring, the NFC West teams average 25.7 points per game.

Defensively, the 49ers rank 13th in the league, allowing an average of 21.8 points per game. Opponents rush for an average of 4.3 yards per carry and 107.8 yards per game. Through the air, San Francisco has given up 3,951 yards this season, placing them 25th in the league. This translates to an average of 232.4 passing yards allowed per game, with a completion rate of 68.2%. Overall, they yield 340.2 yards per game, ranking them 20th in professional football. They have allowed 29 passing touchdowns and 13 rushing touchdowns, resulting in a total of 1,833 rushing yards conceded through 17 matchups.

The Seattle Seahawks enter this game with an impressive record of 14-3 this season. In their last game, they secured a narrow victory over the 49ers, winning 13-3. Running back Zach Charbonnet carried the ball 17 times for 74 yards, averaging 4.4 yards per carry. The passing game featured Jaxon Smith-Njigba, who caught six passes for 84 yards, averaging 14.0 yards per reception. Quarterback Sam Darnold threw for 198 yards on 20 completions out of 26 attempts, achieving a QB rating of 97.9 without any interceptions, averaging 7.6 yards per attempt. Seattle allowed 12 rushing attempts for 53 yards (4.4 yards per rush). Defensively, the Seahawks allowed a completion rate of 70.4%, giving up 120 yards on 19 of 27 passing plays. With 361 total yards on 65 plays, Seattle averaged 5.6 yards per play, rushing for 180 yards on 39 carries, averaging 4.6 yards per carry.

This season, the Seattle Seahawks have averaged 351.4 yards per game, ranking 8th overall. They have accumulated 123.3 rushing yards per game and a total of 2,096 rushing yards this year. The Seahawks have thrown 15 interceptions alongside granting 13 fumbles and recorded a total of 179 first downs. Penalties have cost Seattle 793 yards from 100 infractions, which ranks them 25th in the league in terms of yardage lost. Their passing game has yielded a total of 3,877 yards, averaging 228.1 yards per game, ranking 8th in NFL stats. In terms of scoring, the Seahawks sit 3rd in the league, averaging 28.4 points per game.

Defensively, they’ve permitted 20 passing touchdowns, with an average of 193.9 passing yards allowed per game, ranking 10th overall. Seattle has given up a total of 1,563 rushing yards (91.9 yards per game), allowing 9 rushing touchdowns this season. Their defense has managed to create 25 turnovers (7 forced fumbles and 18 interceptions) throughout the season, allowing a total of 292 points. Additionally, Seattle’s defense has been on the field for 1,065 plays, ranked 23rd in the league. They are yielding just 17.2 points per game, leading the league in defensive performance.

Who will cover the spread in this anticipated 49ers vs. Seahawks matchup?

Prediction: Bet on the Seahawks -7.5

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Pick: Seattle Seahawks -7.5
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