- Matchup: San Francisco 49ers vs. Tampa Bay Buccaneers
- Date: Sunday, October 12, 2025
- Venue: Raymond James Stadium, Tampa, FL
- Broadcast: CBS
- Betting Odds: Buccaneers favored by 3 points
- Over/Under Total: 47.5
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The San Francisco 49ers (4-1) will clash with the Tampa Bay Buccaneers (4-1) this Sunday at Raymond James Stadium. The 49ers enter the game as 3-point underdogs, with an over/under line set at 47.5 points.
Currently holding a 4-1 record, the 49ers recently triumphed over the Los Angeles Rams, winning 26-23. Leading the way was Christian McCaffrey, who rushed 22 times for 57 yards (2.6 yards per carry). Kendrick Bourne shined in the passing game, totaling 142 yards from 10 receptions, averaging 14.2 yards per catch. Quarterback Mac Jones completed 33 of 49 passes for 342 yards, throwing two touchdown passes without any interceptions, achieving a QB rating of 100.9. On defense, the 49ers allowed 78 rushing yards on 16 carries, averaging 4.9 yards per rush, and 30 completed passes for 378 yards, with a completion percentage of 63.8%. On offense, they ran 82 plays for a total of 407 yards, gaining just 74 yards on the ground from 33 attempts for an average of 2.2 yards.
For the season, the 49ers have accumulated 1,879 total yards, registering 80 first downs while facing 32 penalties for 268 yards. They have scored 10 touchdowns through the air, with no rushing touchdowns, and have committed 8 turnovers (5 interceptions and 3 fumbles lost). Their offensive rushing average is 85.2 yards per game, ranking 28th in the league, while they average 21.2 points per game.
On the defensive front, the 49ers rank 6th in the NFL, allowing 19.6 points per game. Opponents average 4.1 yards per carry against them, totaling 108.0 rushing yards per game. Through the air, they’ve given up 1,038 passing yards, ranking 15th, with an average of 207.6 yards allowed per game and a completion percentage of 67.1%. Overall, they surrender 315.6 yards per game, placing them 15th in the league. They have allowed 8 passing touchdowns and 2 rushing touchdowns, with a total of 540 rushing yards given up in five games.
The Buccaneers, also boasting a record of 4-1, are coming off a thrilling 38-35 victory against the Seattle Seahawks. Quarterback Baker Mayfield shone in this clash, racking up 379 yards on 29 of 33 passes with 2 touchdowns, showcasing a stellar quarterback rating of 134.7, while avoiding any interceptions. Rachaad White contributed on the ground, rushing 14 times for 41 yards with an average of 2.9 yards per carry. Emeka Egbuka led the receiving corps, securing 7 catches for 163 yards, averaging an impressive 23.3 yards per reception. Despite finishing the game with only 56 rushing yards from 24 attempts (2.3 yards per attempt), the Buccaneers managed a total of 426 yards on 57 plays (7.5 yards per play). Defensively, they allowed a high completion percentage of 82.4%, yielding 341 passing yards on 28 completions from 34 attempts, and conceded 122 rushing yards on 20 carries (6.1 yards per rush).
The Tampa Bay Buccaneers average 353.8 total yards per game, ranking 11th in the NFL. They manage 110.4 rushing yards per game, totaling 552 rushing yards for the season. The team has recorded just one interception, allowed one fumble, and has achieved 58 first downs. The Buccaneers’ penalty statistics show 35 infractions resulting in 306 total yards, placing them 18th in this category. In passing, they notably rank 6th in the league with 1,217 total passing yards and an average of 243.4 yards per game. The Buccaneers’ scoring prowess places them 7th, averaging 27.0 points per game.
Defensively, the Buccaneers are allowing 26.4 points per game, putting them at 23rd. They have surrendered 10 passing touchdowns and allow an average of 218.4 passing yards per game, ranking 20th. Their run defense has yielded a total of 462 rushing yards this season (92.4 yards per game) along with 4 rushing touchdowns. Having faced 292 total plays from scrimmage, the Buccaneers’ defense ranks 12th in the league, forcing a total of 4 turnovers (2 fumble recoveries and 2 interceptions) and allowing 132 points.
Who will emerge victorious in this 49ers vs. Buccaneers matchup against the spread?
Prediction: Opt for the Buccaneers -3
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