San Francisco Giants vs San Diego Padres Preview, 8/20/2025 MLB Predictions, Top Picks & Odds

Home » San Francisco Giants vs San Diego Padres Preview, 8/20/2025 MLB Predictions, Top Picks & Odds

Matchup: San Francisco Giants vs San Diego Padres

Date: Wednesday, August 20, 2025

Venue: Petco Park, San Diego, CA

Broadcast: Padres.TV

Betting Odds: San Francisco (+106) San Diego (-128)

On Wednesday, the San Diego Padres (69-56) will host the San Francisco Giants (61-64) at Petco Park. The betting line shows San Francisco at +106, while San Diego stands at -128, with a total set at 8 runs. The starting pitchers for the game are Landen Roupp and JP Sears.

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This season, the Giants have collectively achieved 188 doubles and launched 119 home runs. San Francisco is recording a slugging percentage of .376 and has been struck out 1,072 times, while also drawing walks 422 times. As a team, the Giants are scoring 4.1 runs per game, placing them 25th in the league. They’ve amassed 488 RBIs and 966 hits this season, with a batting average of .233. They have scored a total of 509 runs with an on-base percentage of .309.

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San Francisco’s pitching staff holds a strikeout to walk ratio of 2.69 and boasts a combined WHIP of 1.28. They have allowed 108 home runs and 510 runs total, ranking 7th in the league. The Giants have given up 1,026 hits (averaging 8.3 per 9 innings) and recorded 452 earned runs. With an ERA of 3.67, they sit 5th among MLB teams and have struck out 1,055 batters. Their pitching staff has issued 392 walks, maintaining a FIP of 3.67 this season.

Throughout the year, the Giants have utilized 397 relievers, who have inherited 138 base runners, with 34.1% of those scoring. The team has accumulated 29 saves so far and converted 29 out of 47 save chances. Their relievers have a save percentage of 61.7%, having engaged in 117 save situations and recording 70 holds (13th in MLB). The bullpen has entered games with runners on base 88 times and has had 138 high-leverage appearances.

The Seattle Mariners have achieved 3,324 putouts, 1,180 assists, and recorded 73 errors, giving them a fielding percentage of .984, ranking 23rd in the league. The Giants have successfully converted 68.7% of balls in play into outs across 9,972 innings, positioning them 27th in the majors.

Roupp, with a career record of 8-8, holds a FIP of 3.45, having faced 679 batters in his MLB career. He has surrendered 151 hits (averaging 8.8 hits per nine innings) and recorded 69 walks. His career ERA stands at 3.50 (with 60 ER allowed) and he bears a WHIP of 1.427. So far, Roupp has pitched 154 innings and has tallied 147 strikeouts.

The Padres have hit 106 home runs and driven in 485 RBIs this season. They’ve also recorded 200 doubles, walked 406 times, and scored 518 runs. The San Diego Padres currently hold an on-base percentage of .321 and a batting average of .251. Their slugging percentage is at .383, providing an average of 4.14 runs per game (23rd in the league). The team has been struck out 871 times (28th in MLB) and accumulated 1,049 hits.

San Diego’s pitching staff maintains a WHIP of 1.207 and a FIP of 3.89 this year. They lead the league in total hits allowed with 923. The Padres’ pitchers have conceded 475 runs, holding an ERA of 3.58 (with 439 earned runs). The strikeout to walk ratio is an outstanding 8.70 (1,074 strikeouts against 411 walks). This season, they’ve allowed 124 home runs and concede an average of 3.87 runs per nine innings (3rd in MLB).

The Padres have converted 94 double plays and boast a .987 fielding percentage (13th in MLB). Their defense includes 948 assists, 57 errors, and a total of 3,315 putouts for the year. With 9,945 innings played, the Padres have a defensive efficiency rating of 71.6% (2nd in the majors).

Sears, with a career record of 29-40, has an ERA of 4.53 and allows 8.8 hits per nine innings. He has a K/BB ratio of 2.90 and has faced 2,279 hitters during his career. He’s surrendered 271 earned runs while accumulating a WHIP of 1.263 and a FIP of 4.5. Over his MLB career, Sears has given up 526 hits and accumulated 450 strikeouts in 539 innings.

Who will emerge victorious in tonight’s MLB matchup, covering the spread or winning outright?

Tony Sink’s Pick: Bet on San Francisco (+106)

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