St. Louis Cardinals vs San Francisco Giants Forecast, 9/23/2025 MLB Picks, Top Bets & Odds

Home » St. Louis Cardinals vs San Francisco Giants Forecast, 9/23/2025 MLB Picks, Top Bets & Odds
  • Matchup: St. Louis Cardinals vs. San Francisco Giants
  • Event Date: Tuesday, September 23, 2025
  • Venue: Oracle Park, San Francisco, CA
  • Broadcast: NBC Bay Area
  • Betting Odds: St. Louis (+125) | San Francisco (-145)

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Oracle Park will host the exciting clash as the San Francisco Giants (77-79) go up against the St. Louis Cardinals (76-80) on Tuesday. Current betting odds show St. Louis at +125, while San Francisco is at -145. The over/under for this matchup is pegged at 8.5 runs, with Andre Pallante and Logan Webb designated as the starting pitchers.

MLB Picks: Matt Chapman, San Francisco Giants Predictions, Best Bet Odds

The St. Louis Cardinals are currently hitting .378 and have recorded 1,253 strikeouts while drawing 455 walks. The team boasts 628 RBIs along with 1,278 hits throughout the season, culminating in a batting average of .246. The Cardinals have achieved 247 doubles and launched 142 home runs, scoring a total of 662 runs and holding an on-base percentage (OBP) of .315. As a collective unit, the Cardinals average 4.3 runs per game, ranking 19th in the league.

With a strikeout-to-walk ratio of 2.60, the pitching squad showcases a WHIP of 1.32. The Cardinals’ pitchers have given up 157 home runs and a total of 715 runs (22nd in MLB). St. Louis has allowed 1,370 hits (9.0 per 9 innings) and has 648 earned runs, resulting in a team ERA of 4.25 (21st in baseball). Their staff has recorded 1,151 strikeouts, issued 442 walks, and holds a FIP of 4.02 for the year.

The Cardinals’ relief pitchers have participated in 150 high-leverage situations this season, with a total of 151 appearances. They have notched 86 holds (15th in MLB) and a save rate of 63.5%, entering 163 save opportunities and successfully converting 40 saves while failing in 23 of those chances. Their relief squad has inherited 208 runners, with 33.2% of them scoring. Throughout the season, the Cardinals have utilized 461 relief pitchers.

Defensively, St. Louis has converted 69.0% of balls in play into outs over 12,357 innings, ranking them 22nd in the majors. They have accumulated 4,119 putouts, 1,489 assists, and 75 errors, resulting in a fielding percentage of .987, placing them 10th in the league, while also completing 121 double plays.

Pallante has pitched 457 innings, generating 317 strikeouts in his career. He carries an ERA of 4.31 (219 earned runs allowed) with a WHIP of 1.415. Pallante has surrendered 469 hits (9.2 hits per 9 innings) and issued 178 walks, sporting a career win-loss record of 24-29 and a FIP of 4.25. He has faced 1,969 batters in the majors.

The San Francisco Giants have recorded 164 home runs and 641 RBIs this season, along with 228 doubles and 532 walks, totaling 671 runs scored. Their on-base percentage stands at .311, and their batting average is .235. The Giants’ team slugging percentage is .385, and they average 4.33 runs per game (17th in the league). They have struck out 1,329 times (12th in the league) and accrued 1,209 hits.

The Giants’ pitching staff has a WHIP of 1.304 and a FIP of 3.77. Their strikeout-to-walk ratio is an impressive 8.50 (1,291 strikeouts vs. 490 walks). They rank 21st in the league for total hits allowed, yielding 1,297 hits, including 136 home runs, surrendering 4.33 runs per 9 innings (13th in baseball). San Francisco’s pitchers have conceded 659 runs, resulting in a team ERA of 3.87 (589 earned runs allowed).

San Francisco’s relief pitchers have a 37.5% inherited score percentage for 184 inherited runners. This season, the bullpen has been called upon 163 times in high-pressure situations and 117 times with runners on base. With 135 save chances, the Giants have recorded 79 holds and 20 blown saves, listing 11th in MLB with a save rate of 64.3%. They have utilized 492 relief pitchers in total, achieving 36 saves through 56 save opportunities.

Defensively, over 12,336 innings, the Giants have achieved a defensive efficiency of 68.4% (27th in baseball). They have completed 126 double plays and posted a .984 fielding percentage (23rd in MLB) with 1,450 assists, 91 errors, and 4,112 putouts throughout the season.

Webb, with a career record of 69-53, holds an impressive 3.39 ERA while allowing 8.6 hits per nine innings. His strikeout-to-walk ratio is 3.96, and he has faced a total of 4,306 batters. Webb has given up 396 earned runs, sporting a WHIP of 1.197 and a FIP of 3.3. Throughout his MLB career, he has surrendered 1,009 hits while striking out 981 batters over 1,050 innings pitched.

Who will clinch victory in tonight’s MLB showdown, covering the spread or moneyline?

Pick: Back St. Louis (+125)

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Pick: St. Louis Cardinals (+125)
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