Toledo Rockets vs Louisville Cardinals Preview, 12/23/2025 College Football Predictions, Top Picks & Odds

Home » Toledo Rockets vs Louisville Cardinals Preview, 12/23/2025 College Football Predictions, Top Picks & Odds

  • Matchup: Toledo Rockets vs. Louisville Cardinals
  • Date: Tuesday, December 23, 2025
  • Venue: Flagler Credit Union Stadium, Boca Raton, FL
  • Broadcast: ESPN
  • Betting Odds: Cardinals favored by 6.5 points
  • Point Total: 44.5

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The Louisville Cardinals, sporting an 8-4 record, are set to face off against the Toledo Rockets, who also hold an 8-4 record, at Flagler Credit Union Stadium on Tuesday, December 23, 2025, in the Bush’s Boca Raton Bowl. The Cardinals are entering this game as 6.5-point favorites, with a total points line of 44.5.

The Toledo Rockets arrive at this contest with a strong 8-4 record for the season. In their previous game, the Rockets triumphed over the Central Michigan Chippewas, winning decisively with a score of 21-3. On the ground, Toledo allowed just 81 yards from 36 carries, yielding an average of 2.3 yards per rush. Through the air, they permitted 19 completions out of 30 attempts for 242 yards, resulting in a completion rate of 63.3%. Over the course of the game, Toledo executed 61 plays, accumulating a total of 411 yards, including 205 rushing yards on 37 attempts for an average of 5.5 yards per carry.

College football predictions for Toledo Rockets vs. Louisville Cardinals

Offensively, the Toledo Rockets average 31.6 points per game. They boast a total of 177.8 rushing yards per game, placing them 44th in Division 1. So far this season, they have generated 5,062 total yards. In terms of touchdowns, Toledo has registered 26 through the air and 22 on the ground. The Rockets have achieved 256 first downs but have also committed 97 penalties for a total of 871 yards and have 14 turnovers to their name.

Defensively, Toledo has allowed 1,901 passing yards, ranking them 6th in Division 1. They give up an average of 158.4 passing yards per game with a completion percentage allowed of 48.9%. Altogether, Toledo allows 247.8 yards per game, positioning them 2nd in Division 1. The defense has surrendered 10 touchdowns through both passing and rushing, with opponents averaging 2.5 yards per carry and 89.3 rushing yards per game. In total, the Rockets have permitted 1,072 rushing yards across 12 games, leading to a remarkable ranking of 4th in college football with only 12.2 points allowed per game.

The Louisville Cardinals, also at 8-4 this season, enter this contest after a commanding victory over the Kentucky Wildcats, winning 41-0 in their last matchup. During that game, Louisville set a solid ground game with an average of 5.2 yards per carry, totaling 258 yards on 50 attempts. The Cardinals amassed an impressive 440 yards from 71 plays, averaging 6.2 yards per play. Defensively, they allowed a 50.0% completion rate, yielding 100 yards on 13 completions from 26 attempts, while limiting the opposing team to just 40 rushing yards on 26 attempts.

In scoring terms, the Cardinals rank 45th in D-1, averaging 30.2 points per game. Their offense generates 388.8 yards per game, placing them 70th nationally. Louisville has accumulated a total of 774 penalty yards from 84 infractions, ranking them 37th in terms of penalties affecting team performance. The offense has thrown 10 interceptions and lost 7 fumbles, while successfully achieving 235 first downs. Throughout the season, Louisville has passed for 2,716 yards, averaging 226.3 passing yards per game, placing them 67th in D-1. On the ground, they’re posting an average of 162.6 rushing yards per game, totaling 1,951 rushing yards this season.

Defensively, Louisville has allowed 1,318 rushing yards (109.8 yards per game) and 12 touchdowns on the ground throughout the season. They’ve also conceded 14 passing touchdowns and 190.6 passing yards per game, ranking 26th in college football. Throughout the season, the Cardinals have given up a total of 253 points, while recording 5 fumbles and 14 interceptions. Their defensive unit has participated in 768 plays, placing them 27th in college football, and they are allowing 21.1 points per game, ranked 36th overall.

Who will emerge victorious in tonight’s college football clash between the Rockets and the Cardinals against the spread?

Prediction: Back the Rockets at +6.5

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Pick: Rockets at +6.5
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