USF Bulls vs UAB Blazers Prediction for 11/22/2025 College Football Picks, Best Bets & Odds

Home » USF Bulls vs UAB Blazers Prediction for 11/22/2025 College Football Picks, Best Bets & Odds

  • Matchup: USF Bulls vs UAB Blazers
  • Date: Saturday, November 22, 2025
  • Venue: Protective Stadium, Birmingham, AL
  • Broadcast: ESPN+
  • Betting Odds: Blazers (+22.0)
  • Total Points Over-Under: 70

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On Saturday, November 22, 2025, the UAB Blazers (3-7) will face off against the USF Bulls (7-3) at Protective Stadium. UAB enters this contest as underdogs by 22.0 points, with a total points line set at 70.

The USF Bulls arrive with a solid 7-3 record this season. In their most recent outing, they faced the Navy Midshipmen, where they suffered a narrow defeat, ending with a score of 41-38. Defensively, the Bulls allowed 72 rushing yards on 38 attempts, averaging a mere 1.9 yards per rush. Through the air, they conceded 309 yards with 29 completions out of 44 attempts, reflecting a completion rate of 65.9%. Overall, USF executed 69 plays, totaling 556 yards of offense, while their own ground game produced 200 rushing yards on 36 carries, averaging 5.6 yards per carry.

College football predictions USF Bulls vs UAB Blazers

When it comes to scoring, USF averages 41.6 points per game. They rank 11th in Division 1 with an impressive 224.2 rushing yards per game, accumulating a total of 4,923 yards this season. In terms of touchdown production, the Bulls have scored 24 through the air and 24 on the ground. Their offensive stats show 236 first downs and 63 penalties totaling 597 yards, while they’ve committed 14 turnovers throughout the season.

Defensively against the pass, the Bulls rank 122nd in college football, yielding 2,674 yards, averaging 267.4 yards allowed per game with a 64.3% completion rate. Annually, they surrender 400.3 yards per contest, placing them 98th nationally. This season, USF has allowed a total of 15 touchdowns through the air and 16 on the ground, giving up an average of 3.7 yards per carry and 132.9 rushing yards each game. In total, they’ve permitted 1,329 rushing yards in 10 games, ranking 80th in D-1 for points allowed, averaging 25.9 points against per game.

Meanwhile, the UAB Blazers enter this game with a record of 3-7. In their latest encounter, they suffered a defeat against the North Texas Mean Green, finishing at 53-24. On the ground, UAB allowed 208 yards on 34 carries (6.1 yards per rush). The pass defense struggled as well, permitting 298 yards with a completion rate of 72.0% on 18 of 25 attempts. The Blazers accumulated 478 total yards on 82 plays, averaging 5.8 yards per play, and managed 190 rushing yards on 35 carries at 5.4 yards per attempt.

UAB’s offense averages 407.4 yards per game, ranking 53rd in D-1. Their offense has incurred 624 penalty yards from 77 infractions—placing them 12th in the nation for mistakes. The Blazers average 130.4 rushing yards per game, amassing 1,304 rushing yards this season. They’ve thrown 11 interceptions and have had 6 fumbles recovered by opponents, while securing 218 first downs. Regarding scoring, they sit at 73rd nationally, with an average of 26.8 points per game. They’ve also thrown for 2,770 passing yards, averaging 277.0 passing yards per game, which ranks 23rd in college football.

Defensively, UAB has conceded a total of 1,904 rushing yards this season (averaging 190.4 yards per game) and allowed 26 rushing touchdowns. In terms of passing defense, they’ve surrendered 23 touchdowns and allowed 227.5 yards per game, ranking 81st in Division 1. Cumulatively, they’ve allowed 387 points over the season. The Blazers have forced 3 fumbles and recorded 3 interceptions. Their defense has been on the field for 658 plays, giving them the 53rd highest total in the nation. They rank 135th by allowing 38.7 points per game.

Who will triumph in this Bulls vs. Blazers college football matchup against the spread?

Tip: Take the Blazers +22.0

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Pick: UAB Blazers +22.0
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