UTSA Roadrunners vs Charlotte 49ers Prediction for 11/15/2025: College Football Picks, Best Bets & Odds

Home » UTSA Roadrunners vs Charlotte 49ers Prediction for 11/15/2025: College Football Picks, Best Bets & Odds

  • Matchup: UTSA Roadrunners vs. Charlotte 49ers
  • Date: Saturday, November 15, 2025
  • Venue: Jerry Richardson Stadium, Charlotte, NC
  • Broadcast: ESPN+
  • Betting Odds: 49ers (+17.5)
  • Total Points: 61

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The Charlotte 49ers (1-7) are set to battle the UTSA Roadrunners (4-5) on Saturday, November 15, 2025, at Jerry Richardson Stadium. The 49ers enter this contest as 17.5-point underdogs, with the over/under line established at 61 points.

Currently, the UTSA Roadrunners hold a 4-5 record for the season. In their most recent match, they suffered a defeat against the USF Bulls with a score of 55-23. The Roadrunners executed a total of 82 plays, yielding 381 yards. On the ground, they ran the ball 38 times for 72 yards, averaging just 1.9 yards per carry. Unfortunately, they also struggled defensively, allowing 238 yards on 32 attempts, averaging 7.4 yards per rush. Through the air, UTSA allowed 16 completions on 18 attempts, totaling 233 yards, resulting in an impressive completion rate of 88.9%.

College Football Predictions UTSA Roadrunners Best Bets

This season, the Roadrunners have accumulated 3,598 total yards, including 21 passing touchdowns and 14 rushing touchdowns, while committing 9 turnovers. UTSA has secured 184 first downs and has been penalized 70 times for 642 yards. The team averages 166.4 rushing yards per game, placing them 53rd in the nation, while their scoring average stands at 32.8 points per contest.

Defensively, the Roadrunners rank 122nd in Division 1, allowing an average of 33.0 points per game. They give up 4.5 yards per rush and have conceded 158.2 rushing yards per game, totaling 1,424 yards on the ground over 9 games. In terms of pass defense, UTSA has surrendered 2,260 yards, ranking 120th nationally. They allow 251.1 passing yards per game with a completion percentage against of 64.0%. Overall, they concede 409.3 yards per contest, which ranks them 109th in Division 1, giving up 21 touchdown passes and 14 rushing touchdowns so far.

The 49ers enter this matchup with a 1-7 record this season. In their latest game, they fell to the East Carolina Pirates, 48-22. Charlotte’s run defense gave up 44 attempts for 183 yards, averaging 4.2 yards per carry. Their pass defense permitted a completion percentage of 59.1%, allowing 224 yards on 26 completions from 44 attempts. Overall, Charlotte racked up 324 yards on 64 plays (5.1 yards per play) and averaged just 1.4 yards per rushing attempt, finishing with 40 yards on 28 carries.

In the scoring department, the 49ers rank last in Division 1, averaging only 17.5 points per game. They generate an average of 324.9 yards per game, placing them 115th in college football. Charlotte has accrued 424 yards in penalties due to 50 infractions, ranking 93rd in the nation. The 49ers have thrown 7 interceptions and allowed 9 fumbles to be recovered by opponents, garnering 147 first downs this season. To date, they have passed for a total of 1,745 yards, averaging 218.1 yards per game, which ranks 82nd nationwide, and have rushed for 106.8 yards per game with a season total of 854 yards.

Defensively, Charlotte has given up a total of 1,662 rushing yards (207.8 yards per game) and 17 rushing touchdowns this season. They have also allowed 20 passing touchdowns and an average of 270.1 yards per game, placing 127th in college football. They have allowed 298 total points so far and have managed to recover 5 fumbles and make 3 interceptions while their defense has been on the field for 574 plays, ranking them 71st nationally. They are allowing an alarming average of 37.3 points per game, ranking 132nd in Division 1.

Who do you think will cover the spread in tonight’s clash between the Roadrunners and 49ers?

Expert Prediction: Take the 49ers +17.5

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Pick: Charlotte 49ers +17.5
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