- Matchup: Jacksonville Jaguars vs Indianapolis Colts
- Date: Sunday, December 28, 2025
- Venue: Lucas Oil Stadium, Indianapolis, IN
- Broadcast: FOX
- Betting Odds: Colts (+6.5)
- Total Points Over/Under: 48.5
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The Jacksonville Jaguars (11-4) are set to face off against the Indianapolis Colts (8-7) at Lucas Oil Stadium this Sunday. According to Vegas odds makers, the Jaguars are favored by 6.5 points, with the total points set at 48.5.
The Jaguars are entering this matchup with a strong record of 11-4. In their most recent game, they secured a victory against the Denver Broncos, winning 34-20. Quarterback Trevor Lawrence threw for 279 yards, completing 23 of 36 passes, with 3 touchdowns and a quarterback rating of 115.4, free of interceptions. Running back Travis Etienne led the ground attack with 16 carries for 50 yards (3.1 yards per carry). Wide receiver Parker Washington was a standout target, catching 6 passes for 145 yards, averaging 24.2 yards per reception. The Jaguars executed 27 rushing attempts, gaining a total of 81 yards, averaging 3.0 yards per carry. Overall, they completed 63 plays for 346 total yards. On defense, Jacksonville allowed 28 completed passes on 47 attempts for a total of 344 yards, achieving a completion percentage of 59.6%. In terms of their run defense, the Jaguars gave up 101 yards on 17 attempts, averaging 5.9 yards per run.

This season, the Jaguars have accrued a total of 5,046 yards. The team has achieved 167 first downs but has been penalized 119 times for a total of 1,005 yards. In the red zone, Jacksonville has scored 26 passing touchdowns along with 19 rushing touchdowns. However, they have also turned the ball over 16 times (11 interceptions and 5 fumbles). They average 118.1 rushing yards per game, placing them 19th in the NFL, while their scoring average stands at 27.3 points per game.
On defense, the Jaguars have allowed 3,455 passing yards, ranking 24th in the league. They concede 230.3 passing yards per game with a completion percentage allowed of 62.9%. This season, they have given up a total of 1,309 rushing yards over 15 games, resulting in 24 passing touchdowns and 11 rushing touchdowns allowed. Overall, Jacksonville allows 317.6 yards per game, standing 13th in the league, and they rank 10th in points allowed, giving up 20.8 points per game.
The Colts enter the field with an 8-7 record for the season. In their latest game, they suffered a defeat against the San Francisco 49ers, losing 48-27. Running back Jonathan Taylor rushed 16 times, gaining 46 yards for Indianapolis with an average of 2.9 yards per carry. In the passing game, Josh Downs led with 5 receptions for 65 yards (13.0 yards per reception). Quarterback Philip Rivers threw for 277 yards on 23 completions out of 35 attempts, with 2 touchdowns and 1 interception, achieving a QB rating of 97, averaging 7.9 yards per attempt. Defensively, the Colts surrendered 31 rushing attempts for 145 yards (4.7 yards per carry), while allowing a completion rate of 73.5% in the passing game, yielding 295 yards on 25 of 34 passes. The Colts managed a total of 312 yards from 56 plays (averaging 5.6 yards per play), but they struggled to gain traction in the run game, totaling 58 yards on 20 attempts at just 2.9 yards per carry.
On average, the Indianapolis Colts gain 354.8 yards per game, ranking 8th in the NFL. They average 124.1 rushing yards per contest, accumulating 1,862 rushing yards this season. The Colts have thrown 11 interceptions and lost 7 fumbles, while gaining 179 first downs. Their offensive penalties have resulted in 744 yards lost, ranking them 23rd for penalty yards in the league. This season, Indianapolis has thrown for 3,460 yards, averaging 230.7 passing yards per game, placing them 11th in the league. In terms of scoring, they rank 6th, averaging 27.9 points per game.
Defensively, the Colts allow 23.4 points per game, ranking 18th in the NFL. They have conceded 23 passing touchdowns and an average of 250.7 passing yards against them per game, making them 31st in this category. The Colts have given up a total of 1,477 rushing yards this season (averaging 98.5 yards per game) and 13 rushing touchdowns. The defense has participated in 982 snaps from scrimmage, also placing them 31st in the league. They have forced 19 turnovers (6 fumbles and 13 interceptions) during this campaign, resulting in 351 points surrendered overall.
Who will emerge victorious in this Jaguars vs. Colts NFL clash against the spread?
Prediction: Take the Colts +6.5
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