Louisville Cardinals vs Duke Blue Devils Prediction January 26, 2026 College Basketball Picks Best Bets & Odds

Home » Louisville Cardinals vs Duke Blue Devils Prediction January 26, 2026 College Basketball Picks Best Bets & Odds

  • Matchup: Louisville Cardinals vs Duke Blue Devils
  • Date: Monday, January 26, 2026
  • Venue: Cameron Indoor Stadium, Durham, NC
  • Broadcast: ESPN

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The Duke Blue Devils (18-1) are set to take on the Louisville Cardinals (14-5) at Cameron Indoor Stadium this Monday.

College Basketball Predictions: Louisville Cardinals vs. Duke Blue Devils

In their previous game, the Louisville Cardinals triumphed over Virginia Tech with an 85-71 scoreline. Louisville showcased a shooting accuracy of 47.0% (31 of 66) and converted 13 of 33 attempts from beyond the arc. At the free-throw line, the Cardinals successfully made 10 of their 13 attempts, yielding a percentage of 76.9%. They recorded 41 rebounds in total, with 12 being offensive, and dished out 17 assists while forcing 12 turnovers from their opponent, alongside 8 steals. Defensively, Louisville allowed their rivals to hit 40.3% of their field goals (25 of 62). Virginia Tech managed 16 assists and had 5 steals during this match, grabbing 30 total rebounds (9 offensive, 21 defensive) but did not block any shots. The Hokies closed the game with a free-throw percentage of 62.5%, making 5 of 8 attempts, and hit 16 of 30 from long range. The Cardinals committed 14 fouls, in contrast to Virginia Tech’s 18 fouls.

Mikel Brown Jr. was a standout performer, shooting 63.6% from the field, contributing 6 assists, and securing 3 rebounds in 29 minutes of play, amassing 20 points on 7 of 11 shooting.

The Louisville Cardinals come into this match with a record of 14-5 this season. They average an impressive 87.8 points per game, ranking them 19th nationally, while boasting a field goal percentage of 46.9%. From three-point range, the Cardinals are hitting 35.3% (227 of 643) and are successful 77.2% of the time from the free-throw line. On the glass, they average 41.4 rebounds per game and have accumulated 339 assists this season, placing them 53rd in the nation for team assists. They average 11.5 turnovers and commit 19.3 fouls per game.

Defensively, the Cardinals force 12.6 turnovers per game while committing 19.0 fouls. They hold opponents to 33.5% shooting from beyond the arc and rank 80th nationally, allowing 69.6 points per game. Opponents shoot 39.3% (445 of 1,131) against them, and they allow an average of 33.5 rebounds per game. Louisville currently ranks 29th in college basketball for assists allowed, surrendering 220 assists this season.

In their last game, the Duke Blue Devils secured a 90-69 victory against Wake Forest. They allowed Wake Forest to grab 16 rebounds total (4 offensive). Duke shot 43.8% from three-point territory, hitting 14 of 32 attempts, and finished with 11 of 13 from the free-throw line, marking an outstanding 84.6%. Opponents from Wake Forest managed to put down 22 of 54 tries, resulting in a shooting percentage of 40.7%. Duke ended the game shooting 50.0%, hitting 31 of 62 attempts, including 7 of 25 from beyond the arc (28.0%). Wake Forest committed 20 personal fouls, giving Duke a total of 24 free-throw attempts while Duke collected 42 rebounds, split into 26 defensive and 16 offensive.

Cameron Boozer made a significant impact with 32 points during his 33 minutes on the court, registering 4 assists and 9 rebounds, while achieving a shooting rate of 55.0% (11 of 20).

The Blue Devils boast an impressive record of 18-1 this season. They average 16.6 personal fouls per game and maintain a free-throw shooting percentage of 71.7%. Duke averages 17.5 assists per game (37th in the nation) and commits 11.4 turnovers on average. With a total of 1,629 points this season, they mark an average of 85.7 points per contest and collect 40.2 rebounds per game. Their field goal percentage is an impressive 49.8%, ranking 22nd in college basketball.

On defense, Duke limits opponents to 31.1% from three-point range (155 of 498) and allows a free-throw shooting percentage of 73.0%. They concede an average of 12.3 assists and 30.5 rebounds per game, which rank 96th and 17th, respectively. Defensively, Duke is 19th nationally for points allowed, giving up an average of 65.3 points per game and forcing opponents into 13.8 turnovers, while allowing teams to shoot 39.3% from the field (22nd in college basketball).

Who will emerge victorious in this NCAA matchup against the spread?

Prediction: Choose Louisville

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Pick: Louisville Cardinals
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