Chicago Cubs and St. Louis Cardinals Prediction for 8/10/2025: MLB Picks, Best Bets & Odds

Matchup: Chicago Cubs vs St. Louis Cardinals

Date: Sunday, August 10, 2025

Venue: Busch Stadium, St. Louis, MO

Broadcast: FanDuel Sports Network Midwest

Betting Odds: Chicago (-128) St. Louis (+106)

The St. Louis Cardinals (58-58) aim to secure a victory against the Chicago Cubs (66-48) at Busch Stadium this Sunday. The odds for this matchup favor Chicago at -128, while St. Louis is positioned at +106. The over/under for total runs is set at 8, with Shota Imanaga and Sonny Gray starting on the mound.

This season, the Cubs have recorded 194 doubles and launched 164 home runs. Currently, Chicago boasts a slugging percentage of .439 and has struck out 889 times, while drawing 385 walks. As a team, the Chicago Cubs are averaging 5.2 runs per game, ranking them 1st in MLB. They have secured 573 RBIs and collected 992 hits, with a team batting average of .253. Their on-base percentage stands at .323, complemented by 588 total runs scored.

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The Cubs have an earned run average (ERA) of 3.89 this season, placing them 15th in the league. Their pitching staff has achieved 862 strikeouts and has conceded 144 home runs while allowing 473 runs (10th in MLB). Chicago pitchers have walked 296 batters, and their Fielding Independent Pitching (FIP) stands at 4.24. Throughout the season, the Cubs have permitted 937 hits (averaging 8.3 hits per 9 innings), alongside 439 earned runs, with a strikeout-to-walk ratio of 2.91 and a collective WHIP of 1.22.

This season, Cubs pitchers have entered games with baserunners 79 times and have made 110 appearances in high-pressure situations. The bullpen has notched 75 holds, ranking them 7th in the league, and has a save rate of 66.7% from 117 save opportunities, successfully converting 26-of-39 chances. Throughout the season, the Cubs have sent 379 relief pitchers to the mound.

The Cubs have achieved 3,044 putouts this season, alongside 957 assists and 48 errors. Their .988 fielding percentage ranks 6th overall in professional baseball, including 89 double plays. With a defensive efficiency of 71.4%, the Cubs have converted balls in play into outs 71.4% of the time across 9,132 innings, placing them 3rd in the league.

Imanaga has pitched 262 innings in his career, accumulating 244 strikeouts. His career record stands at 23-7, with a FIP of 2.94 against 1,047 batters in Major League Baseball, an earned run average of 2.99 (allowing 87 earned runs), and a WHIP of 1.014. Imanaga has given up 221 hits, averaging 7.6 hits per nine innings, while issuing 45 walks.

The Cardinals boast a team slugging percentage of .388, averaging 4.39 runs per game (14th in the league). They have hit 200 doubles, walked 359 times, and scored a total of 509 runs. With 111 home runs and 485 RBIs this year, St. Louis has struck out 901 times (23rd in the league) and compiled 974 hits. Their on-base percentage is .319, with a batting average of .249.

St. Louis has a WHIP of 1.289 and a team FIP of 3.89 for the year, with a K/BB ratio of 7.40 (839 strikeouts and 304 walks). They rank 26th in MLB for the most hits allowed, with 1,015, conceding 113 home runs and allowing 4.62 runs per nine innings (23rd in MLB). The overall team ERA stands at 4.22, yielding 525 runs throughout the season.

The Cardinals’ relief squad has an inherited score percentage of 33.1% from 151 inherited runners. Their bullpen has faced 111 high-leverage situations and entered games with runners on base 110 times. In 111 save opportunities, they have achieved 64 holds and have blown 15 saves, resulting in a save percentage of 65.9%, placing them 10th in the league. They have utilized 345 bullpen pitchers so far this season, with 29 successful saves from 44 chances.

Defensively, the Cardinals have executed 88 double plays and achieved a fielding percentage of .988, ranking them 8th in professional baseball. They have amassed 1,116 assists, committed 51 errors, and recorded 3,071 putouts over the season. Their defensive efficiency stands at 69.3% across 9,213 innings, ranking 20th in professional baseball.

Throughout his career, Gray has allowed 1,619 hits while accumulating 1,865 strikeouts over the course of 1,865 innings. Gray maintains a 121-99 career record with an earned run average of 3.56 and 7.8 hits allowed per nine innings. He has conceded 737 earned runs, holding a WHIP of 1.192 and a FIP of 3.5, with a strikeout-to-walk ratio of 3.09 against 7,725 hitters.

Who will prevail in this anticipated MLB matchup—will it be against the spread or the moneyline?

Josh Schonwald’s Prediction: Back Chicago (-128)

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