St. Louis Cardinals at Miami Marlins Forecast, 4/21/2026 MLB Selections, Top Picks & Odds

Home » St. Louis Cardinals at Miami Marlins Forecast, 4/21/2026 MLB Selections, Top Picks & Odds

  • Matchup: St. Louis Cardinals vs. Miami Marlins
  • Event Date: Tuesday, April 21, 2026
  • Venue: LoanDepot Park, Miami, FL
  • Broadcast: MLB.TV
  • Betting Odds: St. Louis (-122) Miami (+102)

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The Miami Marlins (10-12) are set to face off against the St. Louis Cardinals (13-8) at LoanDepot Park this Tuesday. The moneyline features St. Louis at -122, while Miami opens at +102. The game total is established at 8 runs, with Dustin May and Chris Paddack taking the mound as starting pitchers.

MLB Predictions: Jordan Walker, St. Louis Cardinals Best Bet Odds

The Cardinals have amassed a total of 28 doubles and launched 25 home runs as a team. They currently hold a slugging percentage of .379, recording 174 strikeouts while drawing 89 walks. As a collective, the St. Louis Cardinals are averaging 4.9 runs per game, placing them 11th in the league. They have compiled 101 RBIs along with 163 hits this season, resulting in a batting average of .233 and an on-base percentage of .328.

The Cardinals’ pitching staff has a strikeout-to-walk ratio of 1.62 with a collective WHIP of 1.41. Unfortunately, they have surrendered 24 home runs and a total of 111 runs (26th in MLB). St. Louis pitchers have allowed 187 hits (8.8 per 9 innings) and 103 earned runs, resulting in an ERA of 4.83 this season (27th in baseball), with 136 strikeouts recorded. The Cardinals’ pitching staff has also walked 84 batters, holding a team FIP of 4.81.

Cardinals relief pitchers have entered 25 times with runners on base and have faced high leverage situations 29 times. They have tallied 19 holds this season (4th in the league) and successfully converted 72.7% of save opportunities. With 8 saves registered and 3 blown saves out of 11 chances, they’ve seen 37 inherited base runners this year, with 40.5% scoring. St. Louis has utilized 80 relief pitchers throughout the season.

Defensively, the Cardinals have converted 70.8% of balls in play into outs over 1,728 innings, ranking 13th in the majors. They have totaled 576 putouts, 211 assists, and 12 errors this season. Their fielding percentage stands at .985, placing them 17th in professional baseball, and have turned 17 double plays.

Dustin May (career record of 21-22) boasts a FIP of 3.98, having faced 1,440 batters in his major league tenure. He has allowed 303 hits (7.9 hits per 9 innings) and 117 walks, with an earned run average of 4.04 (154 ERs allowed) and a WHIP of 1.224. Across 343 innings, May has recorded 312 strikeouts to date in his MLB journey.

The Marlins have achieved a team slugging percentage of .391, averaging 4.55 runs per game (13th in MLB). They’ve recorded 38 doubles, acquired 72 walks, and scored 100 runs, alongside 15 home runs this year and 95 RBIs. They have struck out 177 times (22nd in MLB) and totaled 187 hits, maintaining an on-base percentage of .329 and a batting average of .255.

Miami’s pitching staff holds a team WHIP of 1.275 with a FIP of 4.05. They rank 5th in the league for lowest hits allowed, with 158 this season. Surrendering 101 runs (87 earned) contributes to a team ERA of 4.06. The Marlins have maintained a K/BB ratio of 8.90 (190 strikeouts against 88 walks) and allowed 20 home runs, averaging 4.71 runs per 9 innings (21st in MLB).

In save situations, the Marlins have registered 10 holds with 3 blown saves. Their relievers have faced 9 save opportunities, converting 6 successfully. This season, Miami’s relief corps ranks 10th in baseball with a save rate of 66.7%, pitching in high-leverage situations 19 times and with runners on base 16 times. They’ve sent 64 relief pitchers to the mound this year.

The Miami Marlins have completed 13 double plays while holding a fielding efficiency of .977 (28th in pro baseball). They have achieved 171 assists, made 18 errors, and totaled 579 putouts this season. Over 1,737 innings played, their defensive efficiency stands at 71.1% (11th in baseball).

Throughout his career, Chris Paddack has allowed 604 hits while amassing 547 strikeouts over 600 innings. He has yielded 312 earned runs, with a WHIP of 1.224 and FIP registered at 4.6. His K/BB ratio is 4.18, and he has faced 2,528 batters in his professional career, holding a career win-loss record of 32-39 and an ERA of 4.68, permitting 9.1 hits per 9 innings.

Who will emerge victorious in tonight’s MLB matchup against the spread or moneyline?

Pick: Back St. Louis (-122)

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Pick: St. Louis Cardinals (-122)
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