St. Louis Cardinals vs. Pittsburgh Pirates Preview, 4/28/2026 MLB Predictions, Top Picks & Betting Odds

Home » St. Louis Cardinals vs. Pittsburgh Pirates Preview, 4/28/2026 MLB Predictions, Top Picks & Betting Odds

  • Matchup: St. Louis Cardinals vs. Pittsburgh Pirates
  • Event Date: Tuesday, April 28, 2026
  • Venue: PNC Park, Pittsburgh, PA
  • Broadcast: SportsNet Pittsburgh
  • Betting Odds: St. Louis (+125) Pittsburgh (-150)

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The St. Louis Cardinals (14-13) are traveling to PNC Park on Tuesday to face off against the Pittsburgh Pirates (16-12). The betting line is set with St. Louis at +125 and Pittsburgh at -150, while the over/under stands at 8.5. The anticipated starting pitchers include Kyle Leahy and Braxton Ashcraft.

MLB Predictions: Jordan Walker, St. Louis Cardinals Best Bet and Odds

The Cardinals have collectively recorded 35 doubles and 34 home runs this season. With a slugging percentage of .390, they’ve also struck out 225 times while drawing 101 walks. As a team, St. Louis is averaging 4.6 runs per game, ranking them 13th in MLB. They have amassed 122 RBIs and 212 hits this season, with an overall batting average of .235 and an on-base percentage of .324.

The Cardinals have a strikeout-to-walk ratio of 1.73, while the pitching staff holds a team WHIP of 1.43. Cardinal pitchers have given up 32 home runs and 140 runs (25th in MLB this season). The team has allowed 244 hits (9.0 hits per 9 innings) and 132 earned runs, leading to a team ERA of 4.87 (ranked 27th in baseball). They have struck out 182 batters this season while issuing 105 walks, with a team FIP of 4.82.

This season, Cardinals’ relievers have entered games with runners on 33 occasions and have appeared in 38 high-leverage situations. The bullpen has secured 21 holds (5th in MLB) with a 60.0% save rate, having entered 37 save scenarios. They have successfully converted 9 out of 15 save opportunities, inheriting 48 runners, of which 37.5% have scored. In total, 102 relief pitchers have taken the mound for the Cardinals this year.

The St. Louis Cardinals have totaled 732 putouts, 269 assists, and 14 errors, leading to a .986 fielding percentage, placing them 13th in the league. They have successfully turned 20 double plays this season and converted 70.0% of balls put into play into outs across 2,196 innings, ranking them 16th in MLB.

Leahy has pitched for 162 innings throughout his career, securing 130 strikeouts. With a 7-7 career record, he holds a FIP of 3.88 after facing 680 batters. His career ERA stands at 3.94 with a WHIP of 1.277, having allowed 153 hits (8.5 hits per 9 innings) and issued 54 walks.

The Pirates feature a team slugging percentage of .372, averaging 4.82 runs per game (10th in the league). They have recorded 36 doubles, 135 runs, and 29 home runs this season, with 130 RBIs. Pittsburgh’s offense tallied 271 strikeouts (3rd in the league) and 234 hits, resulting in a team batting average of .241 with an on-base percentage of .325.

The Pittsburgh pitching staff has a WHIP of 1.238 and a team FIP of 3.51. With a strikeout-to-walk ratio of 9.20 (261 strikeouts, 110 walks), they rank 5th in total hits surrendered (207). The Pirates have allowed 19 home runs, yielding 3.90 runs per 9 innings (ranked 5th). This season, the Pittsburgh pitching staff has conceded 111 runs, posting a combined team ERA of 3.34.

The Pirates’ bullpen has faced 27 inherited runners, preventing 29.6% from scoring. They have entered 39 high-pressure situations and 25 with runners on base. With 32 save opportunities, the Pirates have secured 20 holds but suffered from 7 blown saves, ranking 27th in MLB with a 41.7% save percentage. The team has utilized 98 relief pitchers throughout the season.

The Pittsburgh Pirates have executed 19 double plays and recorded a .984 fielding percentage (20th in baseball). This season, they have achieved 225 assists, 16 errors, and 769 putouts. With 2,307 innings played, their defensive efficiency stands at 70.8% (9th in MLB).

In his professional career, Ashcraft has allowed 84 hits, while recording 103 strikeouts over 98 innings pitched. He has allowed 29 earned runs, maintaining a WHIP of 1.189 and a FIP of 2.6. His strikeout-to-walk ratio is 3.12, facing 408 batters in his career. Ashcraft holds a 5-5 career record with an impressive 2.65 ERA, yielding 7.7 hits per nine innings.

Who will emerge victorious in tonight’s MLB matchup—against the spread or the moneyline?

Prediction: Bet on Pittsburgh (-150) and under 8.5 runs

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Pick: Pittsburgh Pirates (-150) and under 8.5 runs
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