Houston Astros and Baltimore Orioles Prediction for 8/22/2025: MLB Picks, Best Bets, and Odds

Home » Houston Astros and Baltimore Orioles Prediction for 8/22/2025: MLB Picks, Best Bets, and Odds

Matchup: Houston Astros vs Baltimore Orioles

Date: Friday, August 22, 2025

Venue: Oriole Park at Camden Yards, Baltimore, MD

Broadcast: MASN

Betting Odds: Houston (-196) Baltimore (+162)

The Baltimore Orioles (59-67) are set to face off against the Houston Astros (69-58) at Oriole Park at Camden Yards this Friday. Current odds place Houston at -196 while Baltimore stands at +162. The over/under for this game is set at 9 runs, with expected starters Lance McCullers Jr. and Cade Povich taking the mound.

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The Astros have recorded 190 doubles this season along with 136 home runs. Houston boasts a collective slugging percentage of .401, has struck out 988 times, and has drawn 364 walks. On average, the Houston Astros score 4.2 runs per game, which ranks them 21st in the league. They have accumulated 507 RBIs and 1,077 hits this season, with a batting average of .254 and an on-base percentage of .319.

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The Astros pitch with a K/BB ratio of 3.10 and a collective WHIP of 1.22. With 151 home runs allowed, their pitching staff has given up 513 runs total, placing them 8th in the MLB. Houston’s pitchers have thrown 975 hits (averaging 7.9 per 9 innings) and 482 earned runs this season, leading to an ERA of 3.89 (13th in MLB). They have also recorded 1,180 strikeouts while yielding 381 walks, with a FIP of 3.93.

The Astros’ bullpen has achieved a save rate of 73.5%, participating in 124 save situations this season. They have inherited 126 base runners, with 27% crossing home plate. The bullpen has faced opponents with runners on base 94 times and has been involved in 124 high leverage scenarios, utilizing 394 relievers throughout the season. The Astros’ relievers have accumulated 73 holds (12th in MLB) and have completed 36 saves out of 49 opportunities.

On defense, the Detroit Tigers have recorded 3,342 putouts, 977 assists, and 50 errors this season, resulting in a fielding percentage of .989, ranking them 6th in baseball. The Astros convert 70.5% of balls put into play into outs over 10,026 innings, placing them 11th in MLB.

McCullers has pitched for 762 innings in the majors, notching 850 strikeouts with a career ERA of 3.68 (312 earned runs allowed) and a WHIP of 1.280. He has permitted 651 hits (averaging 7.7 hits per 9 innings) along with 325 walks, holding a career record of 51-36 and a FIP of 3.63 against 3,233 opposing batters.

The Baltimore Orioles, this season, have maintained a team on-base percentage of .306 with a batting average of .241. They have struck out 1,077 times (10th in the league) and posted 1,009 hits. Baltimore has launched 151 home runs and accumulated 513 RBIs this season. With a slugging percentage of .405, they average 4.34 runs per game (18th in the league). They have also hit 202 doubles, drawn 343 walks, and scored 543 runs overall.

Baltimore’s pitching staff has surrendered 608 runs with a team ERA of 4.68 (572 earned runs). Conceding 166 home runs, they allow 4.97 runs per 9 innings (26th in MLB) and have a WHIP of 1.379 with a FIP of 4.41 as a unit. Their K/BB ratio stands at 8.40 (1,031 strikeouts to 404 walks), ranking them 28th in the league for total hits allowed with 1,114.

This season, Baltimore’s relief pitchers have entered 45 save opportunities, securing 29 saves, placing them 11th in the league with a save rate of 64.4%. They have utilized 420 bullpen pitchers and have seen relievers step in 127 times during high leverage situations, and 123 times when base runners were on. The Orioles’ inherited runner scoring rate is 23.8%, with 132 save situations yielding 84 holds and 16 blown saves.

The Orioles have recorded 89 double plays and maintain a fielding percentage of .986 (18th in professional baseball). This season, they have achieved 1,092 assists, 62 errors, and 3,303 putouts across 9,909 innings, resulting in a defensive efficiency of 68.3% (28th in MLB).

Povich has given up 167 hits in his pro baseball career, recording 159 strikeouts over 160 innings pitched. He has allowed 91 earned runs, with a WHIP of 1.441 and a FIP of 5.0. His strikeout to walk ratio is 2.48 after facing 705 opposing batters. Povich holds a record of 5-15 in his career, with a 5.11 ERA and an average of 9.4 hits per nine innings.

Who will emerge victorious in tonight’s MLB matchup against the spread or moneyline?

Tony Sink’s Prediction: Back Houston (-196)

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